Neutralizing antibodies against IFN- in multiple sclerosis: antagonization of IFN- mediated suppression of MMPs

Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis

2001 • 6,888 citations

Intramuscular interferon beta‐1a for disease progression in relapsing multiple sclerosis

1996 • 2,410 citations

Placebo-controlled multicentre randomised trial of interferon β-1b in treatment of secondary progressive multiple sclerosis

1998 • 931 citations

Generation of biologically active IL-1 beta by matrix metalloproteinases: a novel caspase-1-independent pathway of IL-1 beta processing.

1998 • 687 citations

Shedding of the Matrix Metalloproteinases MMP-2, MMP-9, and MT1-MMP as Membrane Vesicle-Associated Components by Endothelial Cells

2002 • 557 citations

PRISMS-4: Long-term efficacy of interferon-beta-1a in relapsing MS

2001 • 471 citations

Interferon β‐1b decreases the migration of T lymphocytes in vitro: Effects on matrix metalloproteinase‐9

1996 • 363 citations

Neutralizing antibodies during treatment of multiple sclerosis with interferon beta-1b

1996 • 361 citations

Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases.

1994 • 338 citations

Incidence and significance of neutralizing antibodies to interferon beta-1a in multiple sclerosis

1998 • 332 citations

Interferon beta‐1b inhibits gelatinase secretion and in vitro migration of human T cells: A possible mechanism for treatment efficacy in multiple sclerosis

1996 • 302 citations

Matrix metalloproteinases: multifunctional effectors of inflammation in multiple sclerosis and bacterial meningitis

2001 • 251 citations

Matrix metalloproteinase-9 (gelatinase B) is selectively elevated in CSF during relapses and stable phases of multiple sclerosis

1998 • 248 citations

Differential mechanisms of action of interferon-β and glatiramer acetate in MS

2002 • 238 citations

Serum MMP-9 and TIMP-1 levels are related to MRI activity in relapsing multiple sclerosis

1999 • 232 citations

Cytokine and chemokine regulation of proMMP-9 and TIMP-1 production by human peripheral blood lymphocytes.

1997 • 205 citations

Serum gelatinase B, TIMP-1 and TIMP-2 levels in multiple sclerosis

1999 • 199 citations

Bioavailability of interferon beta 1b in MS patients with and without neutralizing antibodies

1999 • 194 citations

Leukocyte Gelatinase B Cleavage Releases Encephalitogens from Human Myelin Basic Protein

1993 • 181 citations

Persistent neutralizing antibodies abolish the interferon β bioavailability in MS patients

2003 • 173 citations

Matrix metalloproteinases in inflammatory demyelination

1999 • 168 citations

The expression profile of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in lesions and normal appearing white matter of multiple sclerosis

2001 • 165 citations

Differential effects of three interferon betas on neutralising antibodies in patients with multiple sclerosis: a follow up study in an independent laboratory

2002 • 149 citations

The evolution of neutralizing antibodies in multiple sclerosis patients treated with interferon β-1b

1999 • 135 citations

Interleukin 10 (IL-10) inhibition of primary human prostate cell-induced angiogenesis: IL-10 stimulation of tissue inhibitor of metalloproteinase-1 and inhibition of matrix metalloproteinase (MMP)-2/MMP-9 secretion.

1999 • 130 citations

Changes of serum sICAM-1 and MMP-9 induced by rIFNβ-1b treatment in relapsing-remitting MS

1999 • 127 citations

[74] Quantitation of neutralization of interferon by antibody

1986 • 127 citations

Matrix metalloproteinases and their tissue inhibitors as markers of disease subtype and response to interferon‐β therapy in relapsing and secondary‐progressive multiple sclerosis patients

2001 • 125 citations

Regulatory mechanisms for the expression of type IV collagenases/gelatinases in murine macrophages.

1994 • 124 citations

Multiple sclerosis is associated with an imbalance between tumour necrosis factor-alpha (TNF-α)- and IL-10-secreting blood cells that is corrected by interferon-beta (IFN-β) treatment

2000 • 109 citations

IFNβ lowers MMP-9/TIMP-1 ratio, which predicts new enhancing lesions in patients with SPMS

2003 • 103 citations

Expression of matrix metalloproteinase-9 and its inhibitors in mononuclear blood cells of patients with multiple sclerosis

1999 • 95 citations

Gelatinase B/matrix metalloproteinase‐9 cleaves interferon‐β and is a target for immunotherapy

2003 • 94 citations

Comparative Study of the Pharmacodynamic and Pharmacologic Effects of Betaseron^®and AVONEX^™

1998 • 92 citations

Evaluation of bioavailability of three types of IFNβ in multiple sclerosis patients by a new quantitative-competitive-PCR method for MxA quantification

2001 • 88 citations

Pharmacokinetics of recombinant human interferon-beta ser in healthy volunteers and its effect on serum neopterin.

1993 • 87 citations

Neutralizing antibodies reduce MxA protein induction in interferon- beta-1a-treated MS patients

2002 • 78 citations

Reprogramming of TIMP‐1 and TIMP‐3 expression profiles in brain microvascular endothelial cells and astrocytes in response to proinflammatory cytokines

1999 • 75 citations

Development of Neutralizing Antibodies in Patients with Relapsing-Remitting Multiple Sclerosis Treated with IFN-β1a

1998 • 75 citations

Rattlesnake Hunting Behavior: Correlations between Plasticity of Predatory Performance and Neuroanatomy

1998 • 65 citations

Pharmacodynamics of Biological Response In Vivo After Single and Multiple Doses of Interferon?????

1993 • 64 citations

Dose Effects of Growth Hormone during Puberty

2003 • 47 citations

Systemic IFN-β treatment induces apoptosis of peripheral immune cells in MS patients

2003 • 47 citations

Interferon beta-1b increases interleukin-10 in a model of T cell–microglia interaction

2000 • 42 citations

Regulation of gelatinase B in human monocytic and endothelial cells by PECAM-1 ligation and its modulation by interferon-beta.

2002 • 28 citations

Modulation of monocytes matrix metalloproteinase-2, MT1-MMP and TIMP-2 by interferon-γ and -β: implications to multiple sclerosis

2002 • 28 citations

Interferon‐β treatment of experimental autoimmune encephalomyelitis leads to rapid nonapoptotic termination of T cell infiltration

2001 • 23 citations