Comparative Study of the Pharmacodynamic and Pharmacologic Effects of Betaseron^®and AVONEX^™

Intramuscular interferon beta‐1a for disease progression in relapsing multiple sclerosis

1996 • 2,410 citations

Interferon beta‐1b is effective in relapsing‐remitting multiple sclerosis

1993 • 2,032 citations

Interferon beta‐1b is effective in relapsing‐remitting multiple sclerosis

1993 • 1,908 citations

Interferon beta‐lb in the treatment of multiple sclerosis

1995 • 899 citations

Biochemistry of Interferons and Their Actions

1982 • 868 citations

The role of IL-10 in crossregulation of TH1 and TH2 responses

1991 • 775 citations

Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery.

1992 • 627 citations

Interleukin‐10 prevents experimental allergic encephalomyelitis in rats

1994 • 377 citations

Interferon β‐1b decreases the migration of T lymphocytes in vitro: Effects on matrix metalloproteinase‐9

1996 • 363 citations

IL-10 inhibits transcription of cytokine genes in human peripheral blood mononuclear cells.

1994 • 328 citations

Interferon beta‐1b inhibits gelatinase secretion and in vitro migration of human T cells: A possible mechanism for treatment efficacy in multiple sclerosis

1996 • 302 citations

Interferon β decreases T cell activation and interferon γ production in multiple sclerosis

1993 • 264 citations

Interferon beta induces interleukin‐10 expression: Relevance to multiple sclerosis

1996 • 240 citations

The interferons: Biological effects, mechanisms of action, and use in multiple sclerosis

1995 • 227 citations

Cytokine mRNA levels in mononuclear blood cells from patients with multiple sclerosis

1994 • 227 citations

In vivo effects of interferon beta-1a on immunosuppressive cytokines in multiple sclerosis

1998 • 220 citations

Increased CD80(+) B cells in active multiple sclerosis and reversal by interferon beta-1b therapy.

1997 • 218 citations

Antagonistic effect of interferon-beta on the interferon-gamma-induced expression of Ia antigen in murine macrophages.

1985 • 207 citations

Side effect profile of interferon beta-lb in MS

1996 • 155 citations

Increases in soluble VCAM‐1 correlate with a decrease in MRI lesions in multiple sclerosis treated with interferon β‐1b

1997 • 155 citations

Recombinant Interferon-β blocks proliferation but enhances interleukin-10 secretion by activated human T-cells

1996 • 122 citations

Interferon effects on interleukin-10 secretion Mononuclear cell response to interleukin-10 is normal in multiple sclerosis patients

1995 • 103 citations

Chemokine-enhanced migration of human peripheral blood mononuclear cells is antagonized by interferon beta-1b through an effect on matrix metalloproteinase-9

1997 • 102 citations

Language dominance in patients with early childhood tumors near left hemisphere language areas

1995 • 92 citations

In vitro and in vivo inhibition of mitogen‐driven T‐cell activation by recombinant interferon beta

1993 • 91 citations

Pharmacokinetics of recombinant human interferon-beta ser in healthy volunteers and its effect on serum neopterin.

1993 • 87 citations

Interferon-β specifically inhibits interferon-γ-induced class II major histocompatibility complex gene transcription in a human astrocytoma cell line

1991 • 86 citations

Human Biologic Response Modification by Interferon in the Absence of Measurable Serum Concentrations: A Comparative Trial of Subcutaneous and Intravenous Interferon-beta serine

1989 • 74 citations

Mechanisms of action of interferon-? in multiple sclerosis

1996 • 68 citations

Pharmacodynamics of Biological Response In Vivo After Single and Multiple Doses of Interferon?????

1993 • 64 citations

A Whole Blood Immunoassay for the Interferon-Inducible Human Mx Protein

1992 • 61 citations

Beta-interferon and multiple sclerosis

1997 • 60 citations

Interferon β-1b effects on cytokine mRNA in peripheral mononuclear cells in multiple sclerosis

1996 • 57 citations

Comparative pharmacokinetics and pharmacodynamics of two recombinant human interferon beta-1a (IFN beta-1 a) products administered intramuscularly in healthy male and female volunteers.

1997 • 56 citations

Low serum interleukin-10 levels in multiple sclerosis: Further evidence for decreased systemic immunosuppression?

1995 • 56 citations

Pharmacokinetics and Pharmacodynamics of Interferon Beta-1a (IFN??-1a) in Healthy Volunteers after Intravenous, Subcutaneous or Intramuscular Administration

1997 • 54 citations

Interleukin-12 and tumor necrosis factor-α levels in cerebrospinal fluid of multiple sclerosis patients

1997 • 48 citations

Evaluation of Routes of Administration of Interferon in Cancer: A Review and a Proposal

1984 • 45 citations

The effect of interferon β-1b on lymphocyte-endothelial cell adhesion

1996 • 40 citations

The pattern of production of cytokine mRNAs is markedly altered at the onset of multiple sclerosis

1996 • 30 citations

Double-Blind Randomized Phase I Study on the Clinical Tolerance and Biological Effects of Natural and Recombinant Interferon-β

1992 • 27 citations

Different Pharmacokinetics Between Natural and Recombinant Human Interferon Beta in Rabbits

1984 • 23 citations

Quantitation of ineterferon-induced Mx protein in whole blood lysates by an immunochemiluminsescent assay: elimination of protease activity of cell lysates in toto

1994 • 21 citations

Biochemical Host Response to Interferon-β

1988 • 21 citations

Double-Blind Randomized Phase I Study on the Clinical Tolerance and Pharmacodynamics of Natural and Recombinant Interferon-β Given Intravenously

1994 • 19 citations

Pharmacokinetics and Antiviral Activity of Recombinant Human Interferon-β_ser17in African Green Monkeys

1993 • 10 citations

Comparative Effects of Interferon-Consensus 1, Interferon-α_2a, and Interferon-/β_lbon HLA Expression and Lymphoproliferation: A Preclinical Model for Treatment of Multiple Sclerosis

1996 • 10 citations

Modulation of α-interferon's antiviral and clinical effects by aspirin, acetaminophen, and prednisone in healthy volunteers

1995 • 4 citations