Back to search

Multiple sclerosis is associated with an imbalance between tumour necrosis factor-alpha (TNF-α)- and IL-10-secreting blood cells that is corrected by interferon-beta (IFN-β) treatment

Data up to Jan 2025

Published2000
Citations109
References47

Total Citations Per Year

Abstract

References (47)

Rating neurologic impairment in multiple sclerosis

1983 • 14,011 citations

New diagnostic criteria for multiple sclerosis: Guidelines for research protocols

1983 • 7,404 citations

Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.

1991 • 3,812 citations

Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. The IFNB Multiple Sclerosis Study Group.

1993 • 1,227 citations

Placebo-controlled multicentre randomised trial of interferon β-1b in treatment of secondary progressive multiple sclerosis

1998 • 931 citations

Multiple Sclerosis: A Coordinated Immunological Attack against Myelin in the Central Nervous System

1996 • 903 citations

Interferon beta‐lb in the treatment of multiple sclerosis

1995 • 899 citations

Studies in myasthenia gravis: review of a twenty-year experience in over 1200 patients.

1971 • 647 citations

IL-6 and APPs: anti-inflammatory and immunosuppressive mediators

1997 • 639 citations

Tumor necrosis factor.

1992 • 601 citations

Reverse ELISPOT assay for clonal analysis of cytokine production I. Enumeration of gamma-interferon-secreting cells

1988 • 496 citations

Interleukin-6 (IL-6)—A molecule with both beneficial and destructive potentials

1997 • 482 citations

[Tumor necrosis factor].

1990 • 340 citations

Interferon beta in the treatment of multiple sclerosis

1998 • 340 citations

Review: cytokines and the pathogenesis of multiple sclerosis

1996 • 331 citations

Cytokine levels in the cerebrospinal fluid and serum of patients with multiple sclerosis

1991 • 330 citations

Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls

1991 • 258 citations

IL-6-deficient mice are resistant to the induction of experimental autoimmune encephalomyelitis provoked by myelin oligodendrocyte glycoprotein

1998 • 229 citations

In vivo effects of interferon beta-1a on immunosuppressive cytokines in multiple sclerosis

1998 • 220 citations

Quantitative intracellular cytokine measurement: age-related changes in proinflammatory cytokine production

1998 • 174 citations

Increased transforming growth factor‐β, interleukin‐4, and interferon‐γ in multiple sclerosis

1994 • 162 citations

IL-6 detection in multiple sclerosis brain

1997 • 160 citations

Interferon beta-1b in the treatment of multiple sclerosis: final outcome of the randomized controlled trial. The IFNB Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis Group.

1995 • 149 citations

Placebo-controlled multicentre randomised trial of interferon beta-1b in treatment of secondary progressive multiple sclerosis. European Study Group on interferon beta-1b in secondary progressive MS.

1998 • 149 citations

Cerebrospinal fluid interleukin 6 in amyotrophic lateral sclerosis: immunological parameter and comparison with inflammatory and non-inflammatory central nervous system diseases

1998 • 148 citations

Direct comparison of ELISPOT and ELISA-based assays for detection of individual cytokine-secreting cells.

1994 • 142 citations

Stressor-Induced Alteration of Cytokine Production in Multiple Sclerosis Patients and Controls

1998 • 123 citations

Recombinant Interferon-β blocks proliferation but enhances interleukin-10 secretion by activated human T-cells

1996 • 122 citations

Acetylcholine receptor-reactive T and B cells in myasthenia gravis and controls.

1991 • 108 citations

Interferon effects on interleukin-10 secretion Mononuclear cell response to interleukin-10 is normal in multiple sclerosis patients

1995 • 103 citations

Augmented expression of tumour necrosis factor-α and lymphotoxin in mononuclear cells in multiple sclerosis and optic neuritis

1996 • 90 citations

Effect of food restriction on life span and immune functions in long-lived Fischer-344 x Brown Norway F1 rats.

1997 • 88 citations

Increased interleukin-6 mRNA expression in blood and cerebrospinal fluid mononuclear cells in multiple sclerosis

1996 • 83 citations

Tumor necrosis factor in serum and cerebrospinal fluid of patients with multiple sclerosis

1989 • 80 citations

High IL-6 and Low IL-10 in the Central Nervous System Are Associated with Protracted Relapsing EAE in DA Rats

1997 • 75 citations

Multiple Sclerosis: Levels of Interleukin‐10‐Secreting Blood Mononuclear Cells are Low in Untreated Patients but Augmented During Interferon‐β‐1b Treatment

1999 • 71 citations

Interferons and Multiple Sclerosis

1994 • 68 citations

Increased mRNA Expression of IL‐10 in Mononuclear Cells in Multiple Sclerosis and Optic Neuritis

1995 • 68 citations

Suppression of acute and protracted-relapsing experimental allergic encephalomyelitis by nasal administration of low-dose IL-10 in rats

1998 • 66 citations

Detection and quantitation of cells secreting IL-6 under physiologic conditions in BALB/c mice.

1993 • 65 citations

Inhibition of Th1 Polarization by Soluble TNF Receptor Is Dependent on Antigen-Presenting Cell-Derived IL-12

1999 • 58 citations

Low serum interleukin-10 levels in multiple sclerosis: Further evidence for decreased systemic immunosuppression?

1995 • 56 citations

A comparison between ELISPOT methods for the detection of cytokine producing cells: greater sensitivity and specificity using ELISA plates as compared to nitrocellulose membranes

1997 • 48 citations

Interferon-Beta in the Treatment of Multiple Sclerosis

2001 • 26 citations

Cellular responses to moderate and heavy exercise

1998 • 25 citations

Interleukin-2 secreting cells in multiple sclerosis and controls

1993 • 23 citations

Cellular responses to moderate and heavy exercise

1998 • 19 citations

Cited By (0)

Loading...
Multiple sclerosis is associated with an imbalance between tumour necrosis factor-alpha… (2000) – Clinical & Experimental Immunology | Metascience Observatory Explorer