Flippases and vesicle-mediated protein transport

The Mechanisms of Vesicle Budding and Fusion

2004 • 1,738 citations

Biological Membranes as Bilayer Couples. A Molecular Mechanism of Drug-Erythrocyte Interactions

1974 • 1,362 citations

Pathophysiologic Implications of Membrane Phospholipid Asymmetry in Blood Cells

1997 • 1,321 citations

Phosphatidylinositol 3-Kinase Encoded by Yeast VPS 34 Gene Essential for Protein Sorting

1993 • 909 citations

Static and dynamic lipid asymmetry in cell membranes

1991 • 796 citations

A Yeast Mutant Showing Diagnostic Markers of Early and Late Apoptosis

1997 • 788 citations

ATP-dependent asymmetric distribution of spin-labeled phospholipids in the erythrocyte membrane: relation to shape changes.

1984 • 692 citations

Adaptable adaptors for coated vesicles

2004 • 672 citations

Asymmetrical Lipid Bilayer Structure for Biological Membranes

1972 • 606 citations

Regulation of transbilayer plasma membrane phospholipid asymmetry

2003 • 543 citations

An essential role for a phospholipid transfer protein in yeast Golgi function

1990 • 534 citations

Stomatocyte–discocyte–echinocyte sequence of the human red blood cell: Evidence for the bilayer– couple hypothesis from membrane mechanics

2002 • 488 citations

A Subfamily of P-Type ATPases with Aminophospholipid Transporting Activity

1996 • 472 citations

The Saccharomyces cerevisiae SEC14 gene encodes a cytosolic factor that is required for transport of secretory proteins from the yeast Golgi complex.

1989 • 381 citations

COLD-SENSITIVE CELL-DIVISION-CYCLE MUTANTS OF YEAST: ISOLATION, PROPERTIES, AND PSEUDOREVERSION STUDIES

1982 • 372 citations

Drs2p-related P-type ATPases Dnf1p and Dnf2p Are Required for Phospholipid Translocation across the Yeast Plasma Membrane and Serve a Role in Endocytosis

2003 • 353 citations

Generation of Coated Intermediates of Clathrin-Mediated Endocytosis on Protein-Free Liposomes

1998 • 345 citations

Phosphoinositides in Constitutive Membrane Traffic

2004 • 293 citations

Phosphatidyl-ethanolamine: Differential labelling in intact cells and cell ghosts of human erythrocytes by a membrane-impermeable reagent

1972 • 287 citations

Role for Drs2p, a P-Type Atpase and Potential Aminophospholipid Translocase, in Yeast Late Golgi Function

1999 • 261 citations

An Essential Subfamily of Drs2p-related P-Type ATPases Is Required for Protein Trafficking between Golgi Complex and Endosomal/Vacuolar System

2002 • 259 citations

Parallel secretory pathways to the cell surface in yeast.

1995 • 257 citations

Cdc50p, a Protein Required for Polarized Growth, Associates with the Drs2p P-Type ATPase Implicated in Phospholipid Translocation inSaccharomyces cerevisiae

2004 • 250 citations

Back and forth

1994 • 241 citations

Assembly of the endoplasmic reticulum phospholipid bilayer: the phosphatidylcholine transporter

1985 • 238 citations

Lipid topogenesis

1981 • 224 citations

The Yeast Clathrin Adaptor Protein Complex 1 Is Required for the Efficient Retention of a Subset of Late Golgi Membrane Proteins

2002 • 215 citations

Transbilayer phospholipid movement and the clearance of apoptotic cells

2002 • 204 citations

Tracking down lipid flippases and their biological functions

2004 • 196 citations

Drs2p-coupled aminophospholipid translocase activity in yeast Golgi membranes and relationship to in vivo function

2004 • 194 citations

Membrane Fission: Model for Intermediate Structures

2003 • 193 citations

Control of transmembrane lipid asymmetry in chromaffin granules by an ATP-dependent protein

1989 • 181 citations

Drs2p-Dependent Formation of Exocytic Clathrin-Coated Vesicles In Vivo

2002 • 164 citations

Chilling Tolerance in Arabidopsis Involves ALA1, a Member of a New Family of Putative Aminophospholipid Translocases

2000 • 159 citations

ATP‐dependent translocation of amino phospholipids across the human erythrocyte membrane

1986 • 157 citations

Enhancement of endocytosis due to aminophospholipid transport across the plasma membrane of living cells

1999 • 146 citations

A subset of yeast vacuolar protein sorting mutants is blocked in one branch of the exocytic pathway

2002 • 144 citations

Phylogenetic Analysis of Sec7-Domain–containing Arf Nucleotide Exchangers

2004 • 139 citations

A Novel Membrane Protein, Ros3p, Is Required for Phospholipid Translocation across the Plasma Membrane inSaccharomyces cerevisiae

2002 • 129 citations

Lem3p Is Essential for the Uptake and Potency of Alkylphosphocholine Drugs, Edelfosine and Miltefosine

2003 • 129 citations

Lipid Bilayer Vesicle Fusion: Intermediates Captured by High-Speed Microfluorescence Spectroscopy

2003 • 127 citations

Identification and Functional Expression of Four Isoforms of ATPase II, the Putative Aminophospholipid Translocase

2000 • 115 citations

Partial purification and characterization of the human erythrocyte Mg²⁺ ‐ATPase A candidate aminophospholipid translocase

1990 • 114 citations

Dynamin and clathrin are required for the biogenesis of a distinct class of secretory vesicles in yeast

2002 • 109 citations

Ultrafast Glycerophospholipid-selective Transbilayer Motion Mediated by a Protein in the Endoplasmic Reticulum Membrane

1996 • 108 citations

The Arf activator Gea2p and the P-type ATPase Drs2p interact at the Golgi in Saccharomyces cerevisiae

2004 • 107 citations

Plasma Membrane Translocation of Fluorescent-labeled Phosphatidylethanolamine Is Controlled by Transcription Regulators, PDR1 and PDR3

1997 • 106 citations

Specific proteins are required to translocate phosphatidylcholine bidirectionally across the endoplasmic reticulum

2000 • 100 citations

Requirement for Neo1p in Retrograde Transport from the Golgi Complex to the Endoplasmic Reticulum

2003 • 94 citations

Loss of Drs2p Does Not Abolish Transfer of Fluorescence-labeled Phospholipids across the Plasma Membrane of Saccharomyces cerevisiae

1998 • 91 citations

Purification and properties of a vanadate- and N-ethylmaleimide-sensitive ATPase from chromaffin granule membranes.

1988 • 88 citations

Differential expression of putative transbilayer amphipath transporters

1999 • 82 citations

ATP-dependent aminophospholipid translocation in erythrocyte vesicles: Stoichiometry of transport

1993 • 81 citations

ADP-ribosylation factor 1 dependent clathrin-coat assembly on synthetic liposomes

1999 • 73 citations

Flippases

1995 • 71 citations

NBD‐Labeled Phosphatidylcholine and Phosphatidylethanolamine are Internalized by Transbilayer Transport across the Yeast Plasma Membrane

2001 • 70 citations

Retrograde lipid traffic in yeast: identification of two distinct pathways for internalization of fluorescent-labeled phosphatidylcholine from the plasma membrane.

1993 • 68 citations

Rapid transbilayer movement of fluorescent phospholipid analogues in the plasma membrane of endocytosis‐deficient yeast cells does not require the Drs2 protein

1999 • 55 citations

Lipids and the exocytotic machinery of eukaryotic cells

2003 • 55 citations

An arf1Δ Synthetic Lethal Screen Identifies a New Clathrin Heavy Chain Conditional Allele That Perturbs Vacuolar Protein Transport in Saccharomyces cerevisiae

1998 • 54 citations

Three dimensional configuration of the secretory pathway and segregation of secretion granules in the yeast Saccharomyces cerevisiae

2001 • 52 citations

Energy-dependent Flip of Fluorescence-labeled Phospholipids Is Regulated by Nutrient Starvation and Transcription Factors, PDR1 and PDR3

2001 • 39 citations

Vanadate-sensitive ATPase from chromaffin granule membranes formed a phosphoenzyme intermediate and was activated by phosphatidylserine

1991 • 34 citations

Reconstitution of yeast microsomal lipid flip-flop using endogenous aminophospholipids

2000 • 27 citations