Contributory effects of de novo transcription and premature transcript termination in the regulation of human epidermal growth factor receptor proto-oncogene RNA synthesis

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

A membrane-filter technique for the detection of complementary DNA

1966 • 3,996 citations

CpG-rich islands and the function of DNA methylation

1986 • 3,760 citations

Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing

1980 • 3,476 citations

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

1984 • 2,762 citations

A system for shotgun DNA sequencing

1981 • 2,710 citations

The Molecular Genetics of Cancer

1987 • 1,729 citations

The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter

1983 • 1,471 citations

Transcription factor AP-2 mediates induction by two different signal-transduction pathways: Protein kinase C and cAMP

1987 • 1,391 citations

RECEPTORS FOR EPIDERMAL GROWTH FACTOR AND OTHER POLYPEPTIDE MITOGENS

1987 • 1,274 citations

Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product

1987 • 902 citations

A block to elongation is largely responsible for decreased transcription of c-myc in differentiated HL60 cells

1986 • 834 citations

Efficient transcription of RNA into DNA by avian sarcoma virus polymerase

1976 • 688 citations

The RNA polymerase II molecule at the 5′ end of the uninduced hsp70 gene of D. melanogaster is transcriptionally engaged

1988 • 662 citations

Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells

1987 • 657 citations

Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane

1984 • 656 citations

Epidermal-Growth-Factor-Dependent Transformation by a Human EGF Receptor Proto-Oncogene

1987 • 448 citations

Expression Cloning of Human EGF Receptor Complementary DNA: Gene Amplification and Three Related Messenger RNA Products in A431 Cells

1984 • 406 citations

Amplification and Enhanced Expression of the Epidermal Growth Factor Receptor Gene in A431 Human Carcinoma Cells

1984 • 400 citations

Characterization and sequence of the promoter region of the human epidermal growth factor receptor gene.

1985 • 391 citations

α-globin-gene switching during the development of chicken embryos: Expression and chromosome structure

1981 • 353 citations

Epidermal growth factor receptors

1981 • 352 citations

A history of the human fetal globin gene duplication

1981 • 349 citations

Over‐expression of the EGF receptor is a hallmark of squamous cell carcinomas

1986 • 330 citations

Intragenic pausing and anti-sense transcription within the murine c-myc locus.

1986 • 326 citations

Inducible binding of a factor to the c-fos enhancer

1986 • 310 citations

Autophosphorylation and protein kinase C phosphorylation of the epidermal growth factor receptor. Effect on tyrosine kinase activity and ligand binding affinity.

1985 • 284 citations

Differential Expression of c- myb mRNA in Murine B Lymphomas by a Block to Transcription Elongation

1987 • 279 citations

Transcriptional arrest within the first exon is a fast control mechanism in c-myc gene expression

1986 • 254 citations

Epidermal growth factor regulates the expression of its own receptor.

1985 • 253 citations

Transcription elongation and eukaryotic gene regulation.

1990 • 227 citations

Epidermal growth factor (EGF) stimulates EGF receptor synthesis.

1986 • 190 citations

Propagation of globin DNAase i-hypersensitive sites in absence of factors required for induction: A possible mechanism for determination

1982 • 189 citations

Structure and localization of genes encoding aberrant and normal epidermal growth factor receptor RNAs from A431 human carcinoma cells.

1985 • 171 citations

Construction of a Novel Oncogene Based on Synthetic Sequences Encoding Epidermal Growth Factor

1987 • 162 citations

Independent mechanisms account for the regulation by protein kinase C of the epidermal growth factor receptor affinity and tyrosine-protein kinase activity.

1988 • 161 citations

Epidermal growth factor stimulates the synthesis of its own receptor in a human breast cancer cell line.

1986 • 145 citations

Epidermal growth factor (EGF) receptor gene transcription. Requirement for Sp1 and an EGF receptor-specific factor.

1988 • 144 citations

Modulation of epidermal growth factor receptor proto-oncogene transcription by a promoter site sensitive to S1 nuclease.

1988 • 143 citations

Dual bidirectional promoters at the mouse dhfr locus: cloning and characterization of two mRNA classes of the divergently transcribed Rep-1 gene.

1989 • 128 citations

Epidermal growth factor receptor gene promoter. Deletion analysis and identification of nuclear protein binding sites.

1988 • 127 citations

The human EGF receptor gene: structure of the 110 kb locus and identification of sequences regulating its transcription.

1987 • 121 citations

Phorbol Ester or Epidermal Growth Factor (EGF) Stimulates the Concurrent Accumulation of mRNA for the EGF Receptor and Its Ligand Transforming Growth Factor-α in a Breast Cancer Cell Line

1989 • 110 citations

A transcription factor active on the epidermal growth factor receptor gene.

1988 • 102 citations

Cooperative Function of Two Separate Enhancers of the Human Epidermal Growth Factor Receptor Proto-oncogene

1989 • 79 citations

Epidermal growth factor receptor expression related to differentiation capacity in normal and transformed keratinocytes

1985 • 78 citations

Epidermal growth factor receptor synthesis is stimulated by phorbol ester and epidermal growth factor. Evidence for a common mechanism.

1987 • 76 citations

Oncogenes, genes, and growth factors

1988 • 74 citations

A cis-acting element in the promoter region of the murine c-myc gene is necessary for transcriptional block.

1989 • 70 citations

Regulation of Epidermal Growth Factor Receptor Gene Expression

1989 • 67 citations

Alternative modes of c-myc regulation in growth factor-stimulated and differentiating cells.

1987 • 65 citations

Functional heterogeneity of proto-oncogene tyrosine kinases: the C terminus of the human epidermal growth factor receptor facilitates cell proliferation.

1989 • 54 citations

Analysis of mammalian fibroblast transformation by normal and mutated human EGF receptors.

1989 • 53 citations

Elements modulating the block of transcription elongation at the adenovirus 2 attenuation site

1989 • 45 citations

RNA secondary structure is an integral part of the in vitro mechanism of attenuation in simian virus 40

1989 • 42 citations

Genetic determinants of neoplastic transformation by the retroviral oncogene v-erbB.

1988 • 42 citations

Regulation of epidermal growth factor receptor number and phosphorylation by fasting in rat liver.

1986 • 38 citations

Transcriptional Regulation of Proto-oncogene Expression by Epidermal Growth Factor, Transforming Growth Factor β1, and Triiodothyronine in MDA-468 Cells

1989 • 38 citations

c-Ha-ras Gene Bidirectional Promoter Expressed In Vitro: Location and Regulation

1989 • 30 citations

Human embryonal carcinoma cells express low levels of functional receptor for epidermal growth factor

1985 • 23 citations