Characterization of the Human Endothelial Nitric-oxide Synthase Promoter

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

Hypertension in mice lacking the gene for endothelial nitric oxide synthase

1995 • 2,075 citations

p53 function and dysfunction

1992 • 1,918 citations

Transcriptional regulation of endothelial cell adhesion molecules: NF‐κB and cytokine‐inducible enhancers

1995 • 1,715 citations

Regulation of biosynthesis of nitric oxide.

1994 • 1,698 citations

Analysis of Sp1 in vivo reveals mutiple transcriptional domains, including a novel glutamine-rich activation motif

1988 • 1,403 citations

Vasculogenesis

1995 • 1,344 citations

Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome

1995 • 994 citations

Elevated blood pressures in mice lacking endothelial nitric oxide synthase

1996 • 888 citations

Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene

1993 • 881 citations

Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling.

1998 • 799 citations

Acylation Targets Endothelial Nitric-oxide Synthase to Plasmalemmal Caveolae

1996 • 798 citations

Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life.

1993 • 778 citations

Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase.

1992 • 748 citations

Sp1-mediated transcriptional activation is repressed by Sp3.

1994 • 692 citations

Transcription from a TATA-less promoter requires a multisubunit TFIID complex.

1991 • 618 citations

Regulation of endothelial cell nitric oxide synthase mRNA expression by shear stress

1995 • 572 citations

Oxidized Low-density Lipoprotein Decreases the Expression of Endothelial Nitric Oxide Synthase

1995 • 547 citations

Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3

1996 • 541 citations

The c-ets proto-oncogenes encode transcription factors that cooperate with c-Fos and c-Jun for transcriptional activation

1990 • 507 citations

Molecular cloning and characterization of human endothelial nitric oxide synthase

1992 • 494 citations

Expression of Multiple Isoforms of Nitric Oxide Synthase in Normal and Atherosclerotic Vessels

1997 • 468 citations

Mechanisms of transcriptional synergism between distinct virus-inducible enhancer elements

1993 • 440 citations

The c-Ets oncoprotein activates the stromelysin promoter through the same elements as several non-nuclear oncoproteins.

1991 • 380 citations

A new pattern for helix–turn–helix recognition revealed by the PU.l ETS–domain–DNA complex

1996 • 307 citations

MAZ, a zinc finger protein, binds to c-MYC and C2 gene sequences regulating transcriptional initiation and termination.

1992 • 291 citations

Sp3 Is a Bifunctional Transcription Regulator with Modular Independent Activation and Repression Domains

1997 • 284 citations

Interaction between transcription factors Spl and YY1

1993 • 282 citations

Ets-1 regulates angiogenesis by inducing the expression of urokinase-type plasminogen activator and matrix metalloproteinase-1 and the migration of vascular endothelial cells

1996 • 276 citations

Cloning of a negative transcription factor that binds to the upstream conserved region of Moloney murine leukemia virus.

1992 • 251 citations

Sp3 encodes multiple proteins that differ in their capacity to stimulate or repress transcription

1997 • 248 citations

Regulation of Cell-Type-Specific Interleukin-2 Receptor α-Chain Gene Expression: Potential Role of Physical Interactions between Elf-1, HMG-I(Y), and NF-κ B Family Proteins

1995 • 244 citations

cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1.

1992 • 242 citations

c-ets1 proto-oncogene is a transcription factor expressed in endothelial cells during tumor vascularization and other forms of angiogenesis in humans.

1992 • 242 citations

DNA bending and orientation-dependent function of YY1 in the c-fos promoter.

1993 • 233 citations

Different members of the Sp1 multigene family exert opposite transcritional regulation of the long terminal repeat of HIV-1

1994 • 231 citations

Gene Structure, Polymorphism and Mapping of the Human Endothelial Nitric Oxide Synthase Gene

1994 • 230 citations

Functional Analysis of the Human Endothelial Nitric Oxide Synthase Promoter

1995 • 223 citations

Regulation of the Ets-Related Transcription Factor Elf-1 by Binding to the Retinoblastoma Protein

1993 • 220 citations

Isolation and Characterization of a Novel Epithelium-Specific Transcription Factor, ESE-1, a Member of the ets Family

1997 • 215 citations

The Serotonin 1a Receptor Gene Contains a TATA-less Promoter that Responds to MAZ and Sp1

1996 • 210 citations

Gene regulation by Ets proteins

1993 • 199 citations

Molecular Regulation of the Bovine Endothelial Cell Nitric Oxide Synthase by Transforming Growth Factor–β ₁

1995 • 194 citations

Cooperative Interaction of GATA-2 and AP1 Regulates Transcription of the Endothelin-1 Gene

1995 • 191 citations

Synergistic activation of the HTLV1 LTR Ets-responsive region by transcription factors Ets1 and Sp1.

1993 • 180 citations

Modulation of Transcription Factor Ets-1 DNA Binding: DNA-Induced Unfolding of an α Helix

1995 • 177 citations

Cloning and Functional Analysis of the Promoter for KDR/flk-1, a Receptor for Vascular Endothelial Growth Factor

1995 • 173 citations

A Nonerythroid GATA-Binding Protein Is Required for Function of the Human Preproendothelin-1 Promoter in Endothelial Cells

1990 • 163 citations

ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation.

1995 • 163 citations

Modulation of Sp1 Phosphorylation by Human Immunodeficiency Virus Type 1 Tat

1998 • 149 citations

A cAMP Response Element and an Ets Motif Are Involved in the Transcriptional Regulation of flt-1 Tyrosine Kinase (Vascular Endothelial Growth Factor Receptor 1) Gene

1996 • 149 citations

Characterization of the Cooperative Function of Inhibitory Sequences in Ets-1

1996 • 145 citations

Mutagenesis of palmitoylation sites in endothelial nitric oxide synthase identifies a novel motif for dual acylation and subcellular targeting.

1995 • 141 citations

Physical interactions between Ets and NF-kappaB/NFAT proteins play an important role in their cooperative activation of the human immunodeficiency virus enhancer in T cells

1997 • 134 citations

Involvement of the Sp3 Transcription Factor in Induction of p21 in Keratinocyte Differentiation

1997 • 134 citations

Organization of the bovine gene encoding the endothelial nitric oxide synthase

1994 • 124 citations

Zeste encodes a sequence-specific transcription factor that activates the Ultrabithorax promoter in vitro

1988 • 121 citations

Repeated CT elements bound by zinc finger proteins control the absolute and relative activities of the two principal human c-myc promoters.

1993 • 120 citations

Oligomerization of Endothelial Nitric Oxide Synthase

1995 • 115 citations

A novel Ets-related transcription factor, Elf-1, binds to human immunodeficiency virus type 2 regulatory elements that are required for inducible trans activation in T cells

1992 • 113 citations

YY1 transcriptional initiator: Protein interactions and association with a DNA site containing unpaired strands

1996 • 103 citations

Elf-1 binds to a critical element in a second CD4 enhancer.

1994 • 92 citations

Novel cis-acting elements in the human platelet-derived growth factor B-chain core promoter that mediate gene expression in cultured vascular endothelial cells.

1994 • 87 citations

Characterization of NERF, a Novel Transcription Factor Related to the Ets Factor ELF-1

1996 • 86 citations

Transcriptional Regulation of Endothelial Nitric-oxide Synthase by Lysophosphatidylcholine

1998 • 79 citations

Sequence-specific interaction of the Ets1 protein with the long terminal repeat of the human T-lymphotropic virus type I

1991 • 75 citations

A Myc-Associated Zinc Finger Protein Binding Site Is One of Four Important Functional Regions in the CD4 Promoter

1995 • 69 citations

Structural coupling of the inhibitory regions flanking the ETS domain of murine Ets‐1

1996 • 66 citations

Multiple Sp1 Binding Sites in the Cardiac/Slow Twitch Muscle Sarcoplamsic Reticulum Ca2⁺-ATPase Gene Promoter Are Required for Expression in Sol8 Muscle Cells

1996 • 63 citations

The Yin and the Yang of mammalian transcription

1992 • 61 citations

Structural Organization and Promoter Analysis of the Bovine Cytochrome c Oxidase Subunit VIIc Gene

1997 • 60 citations

A Potential Role for Elf-1 in Terminal Transferase Gene Regulation

1996 • 59 citations

Structural and functional analyses of DNA bending induced by Sp1 family transcription factors 1 1Edited by T. Richmond

1997 • 55 citations

A single amino-acid substitution in the Ets domain alters core DNA binding specificity of Ets1 to that of the related transcription factors Elf1 and E74

1993 • 55 citations

Pax-3-DNA interaction: flexibility in the DNA binding and induction of DNA conformational changes by paired domains

1994 • 48 citations

Elf-1 regulates basal expression from the T cell antigen receptor zeta-chain gene promoter.

1998 • 45 citations

Activation of the human T-cell leukemia virus type I enhancer is mediated by binding sites for Elf-1 and the pets factor

1993 • 41 citations

Elf-1 Regulates Basal Expression from the T Cell Antigen Receptor ζ-Chain Gene Promoter

1998 • 41 citations

A Sp1 Binding Site in the GC-Rich Region Is Essential for a Core Promoter Activity of the Human Endothelial Nitric Oxide Synthase Gene

1995 • 37 citations

In simple synthetic promoters YY1-induced DNA bending is important in transcription activation and repression

1996 • 35 citations

Importance of low affinity Elf-1 sites in the regulation of lymphoid-specific inducible gene expression.

1996 • 33 citations

ras oncogene-dependent activation of the P4 promoter of minute virus of mice through a proximal P4 element interacting with the Ets family of transcription factors

1996 • 27 citations

Regulation of Human B19 Parvovirus Promoter Expression by hGABP (E4TF1) Transcription Factor

1998 • 27 citations

Functional analysis of the endothelial cell-specific Tie2/Tek promoter identifies unique protein-binding elements

1998 • 26 citations

c-Ets-1 protein is hyperphosphorylated during mitosis.

1993 • 18 citations

Elf-2, a rhombotin-2 binding ets transcription factor: discovery and potential role in T cell leukemia

1997 • 15 citations