The Same Natural Ligand Is Involved in Allorecognition of Multiple HLA-B27 Subtypes by a Single T Cell Clone: Role of Peptide and the MHC Molecule in Alloreactivity

A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules

1995 • 12,826 citations

MOLMOL: A program for display and analysis of macromolecular structures

1996 • 7,169 citations

Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

1991 • 5,267 citations

STRUCTURE AND FUNCTIONS OF THE 20S AND 26S PROTEASOMES

1996 • 2,408 citations

Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein

1995 • 1,528 citations

An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex

1996 • 1,282 citations

Crystal Structures of Two Viral Peptides in Complex with Murine MHC Class I H-2K ^b

1992 • 864 citations

Identification of a Peptide Recognized by Five Melanoma-Specific Human Cytotoxic T Cell Lines

1994 • 841 citations

The antigenic identity of peptide-MHC complexes: A comparison of the conformations of five viral peptides presented by HLA-A2

1993 • 681 citations

The three-dimensional structure of HLA-B27 at 2.1 Å resolution suggests a general mechanism for tight peptide binding to MHC

1992 • 670 citations

Identification of a Graft Versus Host Disease-Associated Human Minor Histocompatibility Antigen

1995 • 429 citations

Guilt by association: HLA-B27 and ankylosing spondylitis

1990 • 418 citations

Presentation of viral antigen controlled by a gene in the major histocompatibility complex

1990 • 381 citations

A naturally occurring peptide recognized by alloreactive CD8+ cytotoxic T lymphocytes in association with a class I MHC protein

1992 • 286 citations

Identification of a tap-dependent leader peptide recognized by alloreactive T cells specific for a class Ib antigen

1994 • 275 citations

HLA‐B27 subtypes in Asian patients with ankylosing spondylitis Evidence for new associations

1995 • 248 citations

Serial triggering of TCRs: a basis for the sensitivity and specificity of antigen recognition

1997 • 235 citations

Naturally processed viral peptides recognized by cytotoxic T lymphocytes on cells chronically infected by human immunodeficiency virus type 1.

1994 • 221 citations

On the nature of peptides involved in T cell alloreactivity.

1991 • 220 citations

Specific T cell recognition of minimally homologous peptides: Evidence for multiple endogenous Ligands

1995 • 209 citations

Self-MHC-restricted peptides recognized by an alloreactive T lymphocyte clone.

1996 • 205 citations

Relevance of residue 116 of HLA‐B27 in determining susceptibility to ankylosing spondylitis

1995 • 202 citations

Several HLA alleles share overlapping peptide specificities.

1995 • 197 citations

An Altered Position of the α2 Helix of MHC Class I Is Revealed by the Crystal Structure of HLA-B*3501

1996 • 160 citations

Alloreactive T cells discriminate among a diverse set of endogenous peptides.

1991 • 136 citations

A single T cell receptor recognizes structurally distinct MHC/peptide complexes with high specificity.

1996 • 131 citations

Dominant aromatic/aliphatic C-terminal anchor in HLA-B*2702 and B*2705 peptide motifs

1994 • 129 citations

Direct identification of an endogenous peptide recognized by multiple HLA-A2.1-specific cytotoxic T cells.

1993 • 128 citations

Cytotoxic T lymphocytes recognize a reconstituted class I histocompatibility antigen (HLA-A2) as an allogeneic target molecule.

1990 • 117 citations

Peptide-independent Recognition by Alloreactive Cytotoxic T Lymphocytes (CTL)

1997 • 110 citations

Distribution of HLA-B27 subtypes in patients with ankylosing spondylitis: the disease is associated with a common determinant of the various B27 molecules.

1987 • 107 citations

Different HLA-B27 subtypes present the same immunodominant Epstein-Barr virus peptide.

1993 • 107 citations

Susceptibility to ankylosing spondylitis correlates with the C-terminal residue of peptides presented by various HLA-B27 subtypes

1997 • 105 citations

Role of endogenous peptides in murine allogenic cytotoxic T cell responses assessed using transfectants of the antigen-processing mutant 174xCEM.T2.

1992 • 83 citations

A rare cryptic translation product is presented by Kb major histocompatibility complex class I molecule to alloreactive T cells.

1995 • 70 citations

Lack of carboxyl–terminal tyrosine distinguishes the B2706–bound peptide repertoire from those of B2704 and other HLA–B27 subtypes associated with ankylosing spondylitis

1997 • 64 citations

Class I-Restricted Alloreactive Cytotoxic T Lymphocytes Recognize a Complex Array of Specific MHC-Associated Peptides

1998 • 62 citations

Rational design of nonnatural peptides as high-affinity ligands for the HLA-B*2705 human leukocyte antigen.

1995 • 60 citations

Differences in endogenous peptides presented by HLA-B*2705 and B*2703 allelic variants. Implications for susceptibility to spondylarthropathies.

1996 • 60 citations

Isolation of a kidney-specific peptide recognized by alloreactive HLA-A3-restricted human CTL.

1995 • 53 citations

A naturally processed peptide presented by HLA-A*0201 is expressed at low abundance and recognized by an alloreactive CD8+ cytotoxic T cell with apparent high affinity.

1997 • 49 citations

Unusual topology of an HLA-B27 allospecific T cell epitope lacking peptide specificity.

1994 • 46 citations

Clonal analysis of alloreactive T cell responses against the closely related B*2705 and B*2703 subtypes. Implications for HLA-B27 association to spondyloarthropathy.

1994 • 46 citations

An HLA-B27 polymorphism (B*2710) that is critical for T-cell recognition has limited effects on peptide specificity

1998 • 46 citations

Alloreactive CD8+ T cells can recognize unusual, rare, and unique processed peptide/MHC complexes.

1996 • 43 citations

The role of MHC class I molecules in the generation of endogenous peptide/MHC complexes.

1995 • 41 citations

Binding of peptides naturally presented by HLA–B27 to the differentially disease–associated B*2704 and B*2706 subtypes, and to mutants mimicking their polymorphism

1996 • 38 citations

The peptide p2Ca is immunodominant in allorecognition of Ld by beta chain variable region V beta 8+ but not V beta 8- strains.

1994 • 35 citations

Modulation of peptide binding by HLA‐B27 polymorphism in pockets A and B, and peptide specificity of B*2703

1995 • 33 citations

HLA‐B27 (B*2701) specificity for peptides lacking Arg2 is determined by polymorphism outside the B pocket

1997 • 33 citations

Novel HY peptide antigens presented by HLA-B27.

1997 • 29 citations

Fine specificity of antigen binding to two class I major histocompatibility proteins (B*2705 and B*2703) differing in a single amino acid residue.

1997 • 28 citations

A patient-derived cytotoxic T-lymphocyte clone and two peptide-dependent monoclonal antibodies recognize HLA-B27-peptide complexes with low stringency for peptide sequences

1996 • 20 citations

Relationship between peptide binding and T cell epitope selection: a study with subtypes of HLA-B27

1998 • 19 citations

Peptide-presenting similarities among functionally distant HLA-B27 subtypes revealed by alloreactive T lymphocytes of unusual specificity.

1992 • 19 citations

Lack of carboxil-terminal tyrosine distinguishes the B*2706-bound peptide repertoire from those of B*2704 and other HLA-B27 subtypes associated to ankylosing spondylitis

1997 • 16 citations

T cell receptor diversity in alloreactive responses against HLA‐B27 (B*2705) is limited by multiple‐level restrictions in both α and β chains

1995 • 9 citations