Identification of HLA-A2–Restricted T-Cell Epitopes Derived From the MUC1 Tumor Antigen for Broadly Applicable Vaccine Therapies

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Vaccination of melanoma patients with peptide- or tumorlysate-pulsed dendritic cells

1998 • 2,916 citations

Vaccination of patients with B–cell lymphoma using autologous antigen–pulsed dendritic cells

1996 • 1,854 citations

Origin, maturation and antigen presenting function of dendritic cells

1997 • 1,375 citations

Generation of mature dendritic cells from human blood An improved method with special regard to clinical applicability

1996 • 1,138 citations

CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells.

1996 • 1,105 citations

The Biochemistry and Cell Biology of Antigen Processing and Presentation

1993 • 1,022 citations

Signals and signs for lymphocyte responses

1994 • 868 citations

Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines.

1996 • 849 citations

Peptides Naturally Presented by MHC Class I Molecules

1993 • 803 citations

Peptide-pulsed dendritic cells induce antigen-specific CTL-mediated protective tumor immunity.

1996 • 746 citations

A highly immunogenic region of a human polymorphic epithelial mucin expressed by carcinomas is made up of tandem repeats.

1988 • 571 citations

Murine dendritic cells loaded in vitro with soluble protein prime cytotoxic T lymphocytes against tumor antigen in vivo.

1996 • 561 citations

HLA-A2.1-Associated Peptides from a Mutant Cell Line: A Second Pathway of Antigen Presentation

1992 • 522 citations

Development of high potency universal DR-restricted helper epitopes by modification of high affinity DR-blocking peptides

1994 • 516 citations

Specific, major histocompatibility complex-unrestricted recognition of tumor-associated mucins by human cytotoxic T cells.

1989 • 453 citations

Bone marrow-generated dendritic cells pulsed with a class I-restricted peptide are potent inducers of cytotoxic T lymphocytes.

1995 • 372 citations

Differentiation of human dendritic cells from monocytes in vitro

1997 • 356 citations

Coexpression of epithelial membrane antigen (EMA), Ki-1, and interleukin-2 receptor by anaplastic large cell lymphomas. Diagnostic value in so-called malignant histiocytosis.

1988 • 343 citations

A core protein epitope of the polymorphic epithelial mucin detected by the monoclonal antibody SM‐3 is selectively exposed in a range of primary carcinomas

1989 • 339 citations

MHC Ligands and Peptide Motifs

1997 • 336 citations

Isolation and sequencing of a cDNA coding for the human DF3 breast carcinoma-associated antigen.

1988 • 310 citations

Humoral immunity against a tandem repeat epitope of human mucin MUC-1 in sera from breast, pancreatic, and colon cancer patients.

1994 • 307 citations

Cancer-associated MUC1 mucin inhibits human T-cell proliferation, which is reversible by IL-2

1998 • 297 citations

Generation of Mature Dendritic Cells from Human Blood

1997 • 297 citations

Antibody and T cell responses of patients with adenocarcinoma immunized with mannan-MUC1 fusion protein.

1997 • 269 citations

In vitro induction of human cytotoxic T lymphocyte responses against peptides of mutant and wild‐type p53

1993 • 267 citations

MUC‐1 Epithelial Tumor Mucin‐Based Immunity and Cancer Vaccines

1995 • 267 citations

Virus-mediated delivery of antigenic epitopes into dendritic cells as a means to induce CTL.

1997 • 256 citations

Reversal of tolerance to human MUC1 antigen in MUC1 transgenic mice immunized with fusions of dendritic and carcinoma cells

1998 • 239 citations

Her-2/neu-derived peptides are tumor-associated antigens expressed by human renal cell and colon carcinoma lines and are recognized by in vitro induced specific cytotoxic T lymphocytes.

1998 • 227 citations

Tissue and tumor distribution of human polymorphic epithelial mucin

1988 • 219 citations

Virus-mediated delivery of antigenic epitopes into dendritic cells as a means to induce CTL.

1997 • 215 citations

Cytotoxic T cells from ovarian malignant tumors can recognize polymorphic epithelial mucin core peptides.

1993 • 213 citations

Presentation of Exogenous Protein Antigens on Major Histocompatability Complex Class I Molecules by Dendritic Cells: Pathway of Presentation and Regulation by Cytokines

1997 • 195 citations

Expression of MUC1 on myeloma cells and induction of HLA-unrestricted CTL against MUC1 from a multiple myeloma patient.

1994 • 180 citations

Tumor-specific cytotoxic T cell clones from patients with breast and pancreatic adenocarcinoma recognize EBV-immortalized B cells transfected with polymorphic epithelial mucin complementary DNA.

1993 • 180 citations

Generation of immunostimulatory dendritic cells from human CD34+ hematopoietic progenitor cells of the bone marrow and peripheral blood.

1995 • 175 citations

Trimming of antigenic peptides in an early secretory compartment.

1994 • 169 citations

Antigen presentation to cytotoxic T lymphocytes in vivo.

1995 • 168 citations

Breast cancer–associated antigen, DF3/MUC1, induces apoptosis of activated human T cells

1996 • 166 citations

Identification of an HLA-A11-restricted epitope from the tandem repeat domain of the epithelial tumor antigen mucin.

1995 • 165 citations

Serum sialyl Tn as an independent predictor of poor prognosis in patients with epithelial ovarian cancer.

1992 • 147 citations

Induction of HLA-A2-restricted CTLs to the mucin 1 human breast cancer antigen.

1997 • 142 citations

Cellular Mucins: Targets for Immunotherapy

2017 • 130 citations

Anti-MUC1 class I restricted CTLs in metastatic breast cancer patients immunized with a synthetic MUC1 peptide

1998 • 127 citations

Dendritic Cells: Antigen Presentation, Accessory Function and Clinical Relevance

1993 • 124 citations

Cellular Mucins: Targets for Immunotherapy

1994 • 102 citations

Selective activation of Fas/Fas ligand-mediated cytotoxicity by a self peptide.

1996 • 97 citations

Specific immunosuppressive activity of epiglycanin, a mucin-like glycoprotein secreted by a murine mammary adenocarcinoma (TA3-HA).

1991 • 84 citations

Phenotypic analysis of human myeloma cell lines

1989 • 74 citations

An empirical method for the prediction of T-cell epitopes

1995 • 73 citations

In vitro induction of MUC-1 peptide-specific type 1 T lymphocyte and cytotoxic T lymphocyte responses from healthy multiparous donors.

1996 • 72 citations

MUC1 peptide epitopes associated with five different H‐2 class I molecules

1997 • 64 citations

Cytotoxic T lymphocytes derived from bone marrow mononuclear cells of multiple myeloma patients recognize an underglycosylated form of MUC1 mucin

1997 • 62 citations

Rapid induction of primary human CD4+ and CD8+ T cell responses against cancer-associated MUC1 peptide epitopes.

1998 • 55 citations

Generation of antigen‐presenting cells for soluble protein antigens ex vivo from peripheral blood CD34⁺ hematopoietic progenitor cells in cancer patients

1996 • 43 citations

Immunoscintigraphy of human mammary carcinoma xenografts using monoclonal antibodies 12H12 and BM-2 labeled with 99mTc and radioiodine.

1994 • 17 citations

B-cell lymphoma marking only with anti-epithelial. Membrane antigen

1989 • 14 citations

Deleted Work

1955 • 0 citations