Identification of the Genes Encoding Cancer Antigens: Implications for Cancer Immunotherapy

A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma

1991 • 3,493 citations

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

Use of Tumor-Infiltrating Lymphocytes and Interleukin-2 in the Immunotherapy of Patients with Metastatic Melanoma

1988 • 2,196 citations

A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma.

1991 • 1,946 citations

Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role

1991 • 1,686 citations

Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein

1995 • 1,528 citations

A p16 ^INK4a -Insensitive CDK4 Mutant Targeted by Cytolytic T Lymphocytes in a Human Melanoma

1995 • 1,147 citations

DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations.

1993 • 1,122 citations

Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor.

1994 • 1,108 citations

Treatment of 283 Consecutive Patients With Metastatic Melanoma or Renal Cell Cancer Using High-Dose Bolus Interleukin 2

1994 • 1,070 citations

A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the sam mRNA

1991 • 1,019 citations

Treatment of Patients With Metastatic Melanoma With Autologous Tumor-Infiltrating Lymphocytes and Interleukin 2

1994 • 991 citations

The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.

1993 • 986 citations

A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.

1994 • 934 citations

Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection.

1994 • 921 citations

Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes.

1994 • 850 citations

Identification of a Peptide Recognized by Five Melanoma-Specific Human Cytotoxic T Cell Lines

1994 • 841 citations

The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes.

1994 • 838 citations

Dominance and Crypticity of T Cell Antigenic Determinants

1993 • 838 citations

Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes.

1994 • 771 citations

A nonapeptide encoded by human gene MAGE-1 is recognized on HLA-A1 by cytolytic T lymphocytes directed against tumor antigen MZ2-E.

1992 • 694 citations

BAGE: a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes

1995 • 598 citations

A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma.

1995 • 591 citations

Melanocyte lineage-specific antigen gp100 is recognized by melanoma-derived tumor-infiltrating lymphocytes.

1994 • 584 citations

Recognition of multiple epitopes in the human melanoma antigen gp100 by tumor-infiltrating T lymphocytes associated with in vivo tumor regression.

1995 • 552 citations

A mutated beta-catenin gene encodes a melanoma-specific antigen recognized by tumor infiltrating lymphocytes.

1996 • 542 citations

Identification of an immunodominant peptide of HER-2/neu protooncogene recognized by ovarian tumor-specific cytotoxic T lymphocyte lines.

1995 • 542 citations

Monoclonal antibodies specific for melanocytic tumors distinguish subpopulations of melanocytes.

1986 • 531 citations

Identification of specific cytolytic immune responses against autologous tumor in humans bearing malignant melanoma.

1987 • 478 citations

Breast and ovarian cancer-specific cytotoxic T lymphocytes recognize the same HER2/neu-derived peptide.

1995 • 446 citations

Immunotherapy of patients with advanced cancer using tumor-infiltrating lymphocytes and recombinant interleukin-2: a pilot study.

1988 • 432 citations

A mutated intron sequence codes for an antigenic peptide recognized by cytolytic T lymphocytes on a human melanoma.

1995 • 416 citations

A peptide encoded by human gene MAGE‐3 and presented by HLA‐A2 induces cytolytic T lymphocytes that recognize tumor cells expressing MAGE‐3

1994 • 379 citations

CCAAT/enhancer-binding protein mRNA is translated into multiple proteins with different transcription activation potentials.

1993 • 372 citations

Expansion of human tumor infiltrating lymphocytes for use in immunotherapy trials

1987 • 361 citations

Vitiligo in Patients with Melanoma

1996 • 335 citations

Induction of anti-tumor cytotoxic T lymphocytes in normal humans using primary cultures and synthetic peptide epitopes.

1994 • 316 citations

Induction of tumor-reactive CTL from peripheral blood and tumor-infiltrating lymphocytes of melanoma patients by in vitro stimulation with an immunodominant peptide of the human melanoma antigen MART-1.

1995 • 296 citations

Reduction of E-cadherin levels and deletion of the alpha-catenin gene in human prostate cancer cells.

1993 • 294 citations

Vitiligo in patients with metastatic melanoma: A good prognostic sign

1983 • 292 citations

Human CD4+ T cells specifically recognize a shared melanoma-associated antigen encoded by the tyrosinase gene.

1994 • 287 citations

Identification of a gene encoding a melanoma tumor antigen recognized by HLA-A31-restricted tumor-infiltrating lymphocytes.

1995 • 282 citations

A new enzymatic function in the melanogenic pathway. The 5,6-dihydroxyindole-2-carboxylic acid oxidase activity of tyrosinase-related protein-1 (TRP1).

1994 • 275 citations

In vitro induction of human cytotoxic T lymphocyte responses against peptides of mutant and wild‐type p53

1993 • 267 citations

Utilization of an alternative open reading frame of a normal gene in generating a novel human cancer antigen.

1996 • 261 citations

Melanoma-specific CD4+ T cells recognize nonmutated HLA-DR-restricted tyrosinase epitopes.

1996 • 259 citations

Interleukin 2 activation of cytotoxic T-lymphocytes infiltrating into human metastatic melanomas.

1986 • 259 citations

Sequential chemoimmunotherapy in the treatment of metastatic melanoma.

1992 • 258 citations

CTL induction by a tumour-associated antigen octapeptide derived from a murine lung carcinoma

1994 • 254 citations

Recognition of tyrosinase by tumor-infiltrating lymphocytes from a patient responding to immunotherapy.

1994 • 247 citations

Cytokine enhancement of DNA immunization leads to effective treatment of established pulmonary metastases.

1996 • 245 citations

Loss of E-Cadherin-Dependent Cell-Cell Adhesion due to Mutation of the β-Catenin Gene in a Human Cancer Cell Line, HSC-39

1995 • 225 citations

Determinant selection of major histocompatibility complex class I-restricted antigenic peptides is explained by class I-peptide affinity and is strongly influenced by nondominant anchor residues.

1994 • 216 citations

The role of HLA class I antigens in recognition of melanoma cells by tumor-specific cytotoxic T lymphocytes. Evidence for shared tumor antigens.

1989 • 215 citations

Mass spectrometric identification of a naturally processed melanoma peptide recognized by CD8+ cytotoxic T lymphocytes.

1995 • 208 citations

Induction of anti-self-immunity to cure cancer

1995 • 207 citations

The melanoma antigen gp75 is the human homologue of the mouse b (brown) locus gene product.

1990 • 203 citations

Implicating a role for immune recognition of self in tumor rejection: passive immunization against the brown locus protein.

1995 • 186 citations

Induction of pigmentation in mouse fibroblasts by expression of human tyrosinase cDNA.

1989 • 186 citations

Presence on a human melanoma of multiple antigens recognized by autologous CTL

1989 • 180 citations

Immunity to Oncogenic Proteins

1995 • 180 citations

Prognostic significance of hypopigmentation in malignant melanoma

1987 • 176 citations

Melanoma cells and normal melanocytes share antigens recognized by HLA-A2-restricted cytotoxic T cell clones from melanoma patients.

1993 • 173 citations

Molecular characterization of the melanocyte lineage-specific antigen gp100.

1994 • 169 citations

A melanocyte-specific gene, Pmel 17, maps near the silver coat color locus on mouse chromosome 10 and is in a syntenic region on human chromosome 12.

1991 • 164 citations

Identification of a tyrosinase epitope recognized by HLA-A24-restricted, tumor-infiltrating lymphocytes.

1995 • 161 citations

Shared human melanoma antigens. Recognition by tumor-infiltrating lymphocytes in HLA-A2.1-transfected melanomas.

1992 • 155 citations

Toward a Genetic Analysis of Tumor Rejection Antigens

1992 • 151 citations

Cloning of a new gene encoding an antigen recognized by melanoma-specific HLA-A24-restricted tumor-infiltrating lymphocytes.

1995 • 145 citations

A monoclonal antibody specific for cells of the melanocyte lineage.

1988 • 143 citations

Identification of human melanoma peptides recognized by class I restricted tumor infiltrating T lymphocytes.

1993 • 140 citations

Specific release of granulocyte-macrophage colony-stimulating factor, tumor necrosis factor-alpha, and IFN-gamma by human tumor-infiltrating lymphocytes after autologous tumor stimulation.

1991 • 138 citations

The Pmel 17/silver locus protein. Characterization and investigation of its melanogenic function.

1994 • 138 citations

A previously unrecognized influenza B virus glycoprotein from a bicistronic mRNA that also encodes the viral neuraminidase.

1983 • 131 citations

Correlation between E-cadherin expression and invasiveness in vitro in a human esophageal cancer cell line.

1993 • 126 citations

CTL specific for the tyrosinase autoantigen can be induced from healthy donor blood to lyse melanoma cells.

1995 • 124 citations

Recognition of human melanoma cells by HLA-A2.1-restricted cytotoxic T lymphocytes is mediated by at least six shared peptide epitopes.

1993 • 122 citations

Recognition of multiple epitopes in the human melanoma antigen gp100 by peripheral blood lymphocytes stimulated in vitro with synthetic peptides.

1995 • 121 citations

Mechanism of translation of monocistronic and multicistronic human immunodeficiency virus type 1 mRNAs.

1992 • 121 citations

IL-2 enhances the function of recombinant poxvirus-based vaccines in the treatment of established pulmonary metastases.

1995 • 117 citations

MHC-restricted recognition of autologous melanoma by tumor-specific cytotoxic T cells. Evidence for restriction by a dominant HLA-A allele.

1991 • 116 citations

Pigmentation-Associated Glycoprotein of Human Melanomas and Melanocytes: Definition with a Mouse Monoclonal Antibody

1985 • 115 citations

A small highly basic protein is encoded in overlapping frame within the P gene of vesicular stomatitis virus

1993 • 113 citations

Cytotoxic T-lymphocyte clones from different patients display limited T-cell-receptor variable-region gene usage in HLA-A2-restricted recognition of the melanoma antigen Melan-A/MART-1.

1995 • 104 citations

Nucleotide sequence of the cDNA encoding human tyrosinase-related protein

1990 • 103 citations

A pigmentation‐associated, differentiation antigen of human melanoma defined by a precipitating antibody in human serum

1983 • 95 citations

Identification of a unique antigen peptide pRL1 on BALB/c RL male 1 leukemia recognized by cytotoxic T lymphocytes and its relation to the Akt oncogene.

1994 • 95 citations

Characterization of the functional specificity of a cloned T-cell receptor heterodimer recognizing the MART-1 melanoma antigen.

1995 • 94 citations

Prominent roles of secondary anchor residues in peptide binding to HLA-A24 human class I molecules.

1995 • 90 citations

Differentiation Antigens of Melanocytes and Melanoma: Analysis of Melanosome and Cell Surface Markers of Human Pigmented Cells With Monoclonal Antibodies

1988 • 90 citations

Distribution of melanoma specific antibody (HMB-45) in benign and malignant melanocytic tumours

1988 • 88 citations

Melanoma‐specific CD4+ T lymphocytes recognize human melanoma antigens processed and presented by epstein‐barr virus‐transformed B cells

1994 • 86 citations

Induction and characterization of cytotoxic T‐lymphocytes recognizing a mutated p21ras peptide presented by HLA‐A*0201

1995 • 84 citations

Common Expression of Melanoma Tumor-Associated Antigens Recognized by Human Tumor Infiltrating Lymphocytes: Analysis by Human Lymphocyte Antigen Restriction

1991 • 84 citations

Costimulation Enhances the Active Immunotherapy Effect of Recombinant Anticancer Vaccines

1996 • 84 citations

Peptide binding to MHC class I molecules: Implications for antigenic peptide prediction

1995 • 81 citations

Ultrastructural localization of HMB‐45 binding sites

1991 • 76 citations

Characterization of natural peptide ligands for HLA‐B*4402 and ‐B*4403: implications for peptide involvement in allorecognition of a single amino acid change in the HLA‐B44 heavy chain

1994 • 75 citations

Specific immune recognition of autologous tumor by lymphocytes infiltrating colon carcinomas: Analysis by cytokine secretion

1993 • 69 citations

T-Cell Recognition of Human Melanoma Antigens

1993 • 68 citations

Multiple specificities in the repertoire of a melanoma patient's cytolytic T lymphocytes directed against tumor antigen MAGE-1.A1.

1995 • 68 citations

Identification of MART-1-specific T-cell receptors: T cells utilizing distinct T-cell receptor variable and joining regions recognize the same tumor epitope.

1994 • 65 citations

Complete Sequence and Expression of a cDNA Encoding a Chicken 115‐kDa Melanosomal Matrix Protein

1991 • 64 citations

Generation of specific anti-melanoma reactivity by stimulation of human tumor-infiltrating lymphocytes with MAGE-1 synthetic peptide

1994 • 61 citations

Regulation and function of non-AUG-initiated proto-oncogenes

1994 • 59 citations

Specific Release of Cytokines by Lymphocytes Infiltrating Human Melanomas in Response to Shared Melanoma Antigens

1993 • 59 citations

T-cell recognition of self peptides as tumor rejection antigens

1996 • 58 citations

Genes Coding for Tumor Antigens Recognized by Human Cytolytic T Lymphocytes

1993 • 56 citations

Isolation of naturally processed peptides recognized by cytolytic T lymphocytes (CTL) on human melanoma cells in association with HLA‐A2.1

1994 • 54 citations

Site-directed mutagenesis of adeno-associated virus type 2 structural protein initiation codons: effects on regulation of synthesis and biological activity

1994 • 54 citations

Translation of bicistronic viral mRNA in transfected cells: regulation at the level of elongation.

1990 • 42 citations

Detection of shared MHC-restricted human melanoma antigens after vaccinia virus-mediated transduction of genes coding for HLA.

1993 • 35 citations

Can antitumor immune responses discriminate between self and nonself?

1994 • 32 citations

Identification of a secreted Mr 95,000 glycoprotein in human melanocytes and melanomas by a melanocyte specific monoclonal antibody.

1988 • 29 citations

Processing of Self-Proteins and Its Impact on Shaping the T Cell Repertoire, Autoimmunity and Immune Regulation

1993 • 23 citations

The cDNA RPE1 and monoclonal antibody HMB-50 define gene products preferentially expressed in retinal pigment epithelium

1992 • 22 citations