Interleukin 1β-converting Enzyme Related Proteases/Caspases Are Involved in TRAIL-induced Apoptosis of Myeloma and Leukemia Cells

The Fas Death Factor

1995 • 4,070 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.

1992 • 3,279 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

Identification and characterization of a new member of the TNF family that induces apoptosis

1995 • 2,890 citations

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

1995 • 2,877 citations

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1994 • 2,575 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.

1995 • 2,142 citations

Lethal effect of the anti-Fas antibody in mice

1993 • 1,915 citations

Features of apoptotic cells measured by flow cytometry

1992 • 1,912 citations

Induction of Apoptosis by Apo-2 Ligand, a New Member of the Tumor Necrosis Factor Cytokine Family

1996 • 1,793 citations

A Manual of Methods for Baculovirus Vectors and Insect Cell Culture Procedures.

1987 • 1,703 citations

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

1995 • 1,662 citations

Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

1995 • 1,625 citations

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 • 1,558 citations

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

1995 • 1,549 citations

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

1994 • 1,549 citations

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas

1995 • 1,346 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

1994 • 1,073 citations

A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain

1995 • 1,007 citations

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

1996 • 980 citations

Involvement of an ICE-like protease in Fas-mediated apoptosis

1995 • 757 citations

Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage.

1995 • 706 citations

Expression of the functional soluble form of human fas ligand in activated lymphocytes.

1995 • 656 citations

A License to Kill

1996 • 649 citations

Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis

1995 • 616 citations

Fas- and Tumor Necrosis Factor-induced Apoptosis Is Inhibited by the Poxvirus crmA Gene Product

1995 • 604 citations

Molecular Ordering of the Cell Death Pathway

1996 • 589 citations

Purification and characterization of the Fas-ligand that induces apoptosis.

1994 • 521 citations

ICE Family Proteases: Mediators of All Apoptotic Cell Death?

1996 • 440 citations

Protection against Fas-dependent Thl-mediated apoptosis by antigen receptor engagement in B cells

1995 • 426 citations

Mch3, a novel human apoptotic cysteine protease highly related to CPP32.

1995 • 391 citations

Fas antigen is the major target molecule for CD4+ T cell-mediated cytotoxicity.

1994 • 386 citations

The mouse fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster

1994 • 335 citations

ICE-LAP3, a Novel Mammalian Homologue of the Caenorhabditis elegans Cell Death Protein Ced-3 Is Activated during Fas- and Tumor Necrosis Factor-induced Apoptosis

1996 • 327 citations

Fas and its ligand in a general mechanism of T-cell-mediated cytotoxicity.

1994 • 294 citations

Hormone-induced cell death. Purification ad properties of thymocytes undergoing apoptosis after glucocorticoid treatment.

1982 • 244 citations

The Role of APO‐1‐Mediated Apoptosis in the Immune System

1994 • 242 citations

Identification and Characterization of CPP32/Mch2 Homolog 1, a Novel Cysteine Protease Similar to CPP32

1996 • 223 citations

Regulation of cell surface APO‐1/Fas (CD95) ligand expression by metalloproteases

1995 • 216 citations

Local Fas/APO‐1 (CD95) ligand‐mediated tumor cell killing in vivo

1995 • 201 citations

Activation of apoptosis by Apo-2 ligand is independent of FADD but blocked by CrmA

1996 • 198 citations

ICE-related proteases in apoptosis

1996 • 163 citations

Myeloma cells express Fas antigen/APO-1 (CD95) but only some are sensitive to anti-Fas antibody resulting in apoptosis

1995 • 138 citations

ICE inhibitor YVADcmk is a potent therapeutic agent against in vivo liver apoptosis

1996 • 97 citations

The APO‐1/Fas (CD95) receptor is expressed in homozygous MRL/lpr mice

1994 • 70 citations

Comparative molecular modelling of the Fas-ligand and other members of the TNF family

1995 • 67 citations

Proteolysis and the biochemistry of life-or-death decisions.

1996 • 56 citations

Expression and function of the murine CD95/FasR/APO‐1 receptor in relation to B cell ontogeny

1995 • 49 citations

Identification and quantitation of apoptotic cells following anti‐CD3 activation of murine G₀ T cells

1993 • 37 citations

Interleukin-1β-converting enzyme and related proteases as potential targets in inflammation and apoptosis

1995 • 30 citations

Expression of biologically active mouse and human CD95/APO-1/Fas ligand in the baculovirus system

1996 • 20 citations