The APO‐1/Fas (CD95) receptor is expressed in homozygous MRL/lpr mice

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Lethal effect of the anti-Fas antibody in mice

1993 • 1,915 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 • 1,558 citations

A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor.

1989 • 1,436 citations

Lpr and gld: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease

1991 • 1,185 citations

Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen.

1992 • 857 citations

Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice.

1993 • 506 citations

Activation interferes with the APO-1 pathway in mature human T cells

1993 • 466 citations

Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide.

1993 • 410 citations

DNA fragmentation and cell death is selectively triggered in activated human lymphocytes by Fas antigen engagement

1992 • 392 citations

Induction of apoptosis by monoclonal antibody anti-APO-1 class switch variants is dependent on cross-linking of APO-1 cell surface antigens.

1992 • 282 citations

The defect in Fas mRNA expression in MRL/lpr mice is associated with insertion of the retrotransposon, ETn.

1993 • 241 citations

The Fas protein is expressed at high levels on CD4+CD8+ thymocytes and activated mature lymphocytes in normal mice but not in the lupus-prone strain, MRL lpr/lpr.

1993 • 210 citations

Selection of the T cell receptor repertoire in Lpr mice.

1993 • 155 citations

Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant mice

1992 • 130 citations

Abnormal thymocyte development and production of autoreactive T cells in T cell receptor transgenic autoimmune mice.

1991 • 97 citations

A specific intercellular pathway of apoptotic cell death is defective in the mature peripheral T cells of autoimmune lpr and gld mice

1994 • 81 citations

Differential expression of APO‐1 on human thymocytes: Implications for negative selection?

1994 • 67 citations

The onset of Fas expression parallels the acquisition of CD8 and CD4 in fetal and adult αβ thymocytes

1994 • 45 citations