Back to search

The CD44-initiated pathway of T-cell extravasation uses VLA-4 but not LFA-1 for firm adhesion

Data up to Jan 2025

Published2000
Citations126
References66

Total Citations Per Year

Abstract

References (66)

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

Lymphocyte Homing and Homeostasis

1996 • 2,934 citations

Leukocyte-endothelial adhesion molecules

1994 • 2,567 citations

Leukocyte-endothelial adhesion molecules

1994 • 1,884 citations

Prevention of experimental autoimmune encephalomyelitis by antibodies against α4βl integrin

1992 • 1,711 citations

Selectins and their ligands: current concepts and controversies

1996 • 1,446 citations

α4 integrins mediate lymphocyte attachment and rolling under physiologic flow

1995 • 1,018 citations

Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma.

1993 • 837 citations

P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues

1997 • 735 citations

The integrin VLA-4 supports tethering and rolling in flow on VCAM-1.

1995 • 716 citations

A human lymphocyte homing receptor, the Hermes antigen, is related to cartilage proteoglycan core and link proteins

1989 • 568 citations

Requirement for CD44 in Activated T Cell Extravasation into an Inflammatory Site

1997 • 560 citations

Distinct roles of L-selectin and integrins α4β7 and LFA-1 in lymphocyte homing to Peyer's patch-HEV in situ: The multistep model confirmed and refined

1995 • 520 citations

Molecular Mechanisms of Lymphocyte Homing to Peripheral Lymph Nodes

1998 • 469 citations

The mouse gut T lymphocyte, a novel type of T cell. Nature, origin, and traffic in mice in normal and graft-versus-host conditions.

1978 • 422 citations

CD44 and its ligand hyaluronate mediate rolling under physiologic flow: a novel lymphocyte-endothelial cell primary adhesion pathway.

1996 • 421 citations

Differential utilization of ICAM-1 and VCAM-1 during the adhesion and transendothelial migration of human T lymphocytes.

1991 • 388 citations

Four molecular pathways of T cell adhesion to endothelial cells: roles of LFA-1, VCAM-1, and ELAM-1 and changes in pathway hierarchy under different activation conditions.

1991 • 343 citations

Proinflammatory stimuli regulate endothelial hyaluronan expression and CD44/HA-dependent primary adhesion.

1998 • 314 citations

Antibodies to CD44 and integrin α4, but not L-selectin, prevent central nervous system inflammation and experimental encephalomyelitis by blocking secondary leukocyte recruitment

1999 • 287 citations

Anti-CD44 treatment abrogates tissue aedema and leukocyte infiltration in murine arthrtis

1995 • 283 citations

T-cell memory: the connection between function, phenotype and migration pathways

1991 • 271 citations

Glycosylation of CD44 negatively regulates its recognition of hyaluronan.

1995 • 255 citations

P-selectin and vascular cell adhesion molecule 1 mediate rolling and arrest, respectively, of CD4+ T lymphocytes on tumor necrosis factor α-activated vascular endothelium under flow.

1995 • 223 citations

Inhibition of in vivo lymphocyte migration to inflammation and homing to lymphoid tissues by the TA-2 monoclonal antibody. A likely role for VLA-4 in vivo.

1991 • 211 citations

Binding of ovarian cancer cells to peritoneal mesothelium in vitro is partly mediated by CD44H.

1993 • 210 citations

Binding of hyaluronic acid to lymphoid cell lines is inhibited by monoclonal antibodies against Pgp-1

1990 • 207 citations

Upregulated expression and function of VLA-4 fibronectin receptors on human activated T cells in rheumatoid arthritis.

1991 • 203 citations

Variant cell lines selected for alterations in the function of the hyaluronan receptor CD44 show differences in glycosylation.

1995 • 196 citations

Measurement of an adhesion molecule as an indicator of inflammatory disease activity: Up‐regulation of the receptor for hyaluronate (CD44) in rheumatoid arthritis

1991 • 190 citations

Mice Lacking Two or All Three Selectins Demonstrate Overlapping and Distinct Functions for Each Selectin

1999 • 189 citations

Glycosylation of CD44 is implicated in CD44-mediated cell adhesion to hyaluronan.

1996 • 187 citations

GlyCAM-1, a physiologic ligand for L-selectin, activates beta 2 integrins on naive peripheral lymphocytes.

1996 • 184 citations

A two-step adhesion cascade for T cell/endothelial cell interactions under flow conditions.

1994 • 168 citations

CD44 activation and associated primary adhesion is inducible via T cell receptor stimulation.

1997 • 163 citations

Hyaluronan binding function of CD44 is transiently activated on T cells during an in vivo immune response.

1994 • 160 citations

Regulation of CD44 binding to hyaluronan by glycosylation of variably spliced exons.

1995 • 154 citations

Distinct cell surface ligands mediate T lymphocyte attachment and rolling on P and E selectin under physiological flow.

1994 • 152 citations

The alpha 4-integrin supports leukocyte rolling and adhesion in chronically inflamed postcapillary venules in vivo.

1996 • 148 citations

The VLA-4/VCAM-1 pathway is involved in lymphocyte adhesion to endothelium in rheumatoid synovium.

1991 • 147 citations

Rat blood neutrophils express very late antigen 4 and it mediates migration to arthritic joint and dermal inflammation.

1996 • 141 citations

Integrin Cross Talk: Activation of Lymphocyte Function-associated Antigen-1 on Human T Cells Alters α4β1- and α5β1-mediated Function

1997 • 139 citations

Inhibition of insulitis and prevention of diabetes in nonobese diabetic mice by blocking L-selectin and very late antigen 4 adhesion receptors.

1993 • 127 citations

Changes in cell adhesion molecule expression on T cells associated with systemic virus infection.

1994 • 113 citations

Neutrophils Can Adhere Via α4β1 -Integrin Under Flow Conditions

1997 • 112 citations

Neutrophils Can Adhere Via α4β1 -Integrin Under Flow Conditions

1997 • 105 citations

The pathogenesis of adoptive murine autoimmune diabetes requires an interaction between alpha 4-integrins and vascular cell adhesion molecule-1.

1994 • 104 citations

Functional activation of lymphocyte CD44 in peripheral blood is a marker of autoimmune disease activity.

1998 • 103 citations

Monocyte migration to arthritis in the rat utilizes both CD11/CD18 and very late activation antigen 4 integrin mechanisms.

1995 • 101 citations

Monoclonal antibodies to the integrin α−4 subunit inhibit the murine contact hypersensitivity response

1993 • 95 citations

T lymphocyte migration to arthritic joints and dermal inflammation in the rat: Differing migration patterns and the involvement of VLA-4

1991 • 86 citations

Dual inhibition of VLA-4 and LFA-1 maximally inhibits cutaneous delayed-type hypersensitivity-induced inflammation.

1993 • 86 citations

CD44 expression on activated B cells. Differential capacity for CD44-dependent binding to hyaluronic acid.

1993 • 85 citations

Selective Requirements for Leukocyte Adhesion Molecules in Models of Acute and Chronic Cutaneous Inflammation: Participation of E- and P- But Not L-Selectin

1999 • 84 citations

Selective Requirements for Leukocyte Adhesion Molecules in Models of Acute and Chronic Cutaneous Inflammation: Participation of E- and P- But Not L-Selectin

1999 • 81 citations

Interleukin 15 Induces Endothelial Hyaluronan Expression in Vitro and Promotes Activated T Cell Extravasation through a Cd44-Dependent Pathway in Vivo

1999 • 78 citations

Lymphocyte function-associated antigen 1 dominates very late antigen 4 in binding of activated T cells to endothelium.

1993 • 76 citations

Administration of Antibodies to Hyaluronanreceptor (CD44) Delays the Start and Ameliorates the Severity of Collagen II Arthritis

1995 • 72 citations

Identification and characterization of two novel lymphocyte function-associated antigens, L24 and L25.

1987 • 66 citations

THE MEDIATOR OF CELLULAR IMMUNITY

1971 • 66 citations

Recruitment of lymphocytes during cutaneous delayed hypersensitivity in nonhuman primates is dependent on E-selectin and vascular cell adhesion molecule 1.

1994 • 61 citations

Antigen-independent processes in antigen-specific immunity. A role for alpha 4 integrin.

1993 • 58 citations

A family of cell-surface glycoproteins defined by a putative anti-endothelial cell receptor antibody in man.

1989 • 55 citations

Immunomodulatory Functions of Low-Molecular Weight Hyaluronate in an Acute Rat Renal Allograft Rejection Model

1999 • 24 citations

Human T lymphocytes bind to germinal centers of human tonsils via integrin α4/VCAM‐1 and LFA‐1/ICAM−1 and −2

1997 • 23 citations

IMMUNOMODULATORY FUNCTIONS OF HYALURONATE IN THE LEW-TO-F344 MODEL OF CHRONIC CARDIAC ALLOGRAFT REJECTION

1999 • 22 citations

Cited By (0)

Loading...
The CD44-initiated pathway of T-cell extravasation uses VLA-4 but not LFA-1 for firm… (2000) – Journal of Clinical Investigation | Metascience Observatory Explorer