Opioid inhibition of formalin-induced changes in plasma extravasation and local blood flow in rats

The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats

1977 • 2,494 citations

The formalin test: an evaluation of the method

1992 • 2,414 citations

Calcitonin gene-related peptide is a potent vasodilator

1985 • 2,050 citations

Local effector functions of capsaicin-sensitive sensory nerve endings: Involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides

1988 • 1,673 citations

Substance P as neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasation

1979 • 1,199 citations

Multiple opiate receptor sites on primary afferent fibres

1980 • 621 citations

Opioids from immunocytes interact with receptors on sensory nerves to inhibit nociception in inflammation.

1990 • 593 citations

Formalin-evoked activity in identified primary afferent fibers: systemic lidocaine suppresses phase-2 activity

1996 • 474 citations

Cyclooxygenase inhibition and the spinal release of prostaglandin E2 and amino acids evoked by paw formalin injection: a microdialysis study in unanesthetized rats

1995 • 305 citations

Opioid Receptors Undergo Axonal Flow

1980 • 274 citations

Simple Method for Quantitation of Enhanced Vascular Permeability

1970 • 271 citations

Substance P release from knee joint afferent terminals: modulation by opioids

1988 • 254 citations

Diminished Inflammation and Nociceptive Pain with Preservation of Neuropathic Pain in Mice with a Targeted Mutation of the Type I Regulatory Subunit of cAMP-Dependent Protein Kinase

1997 • 227 citations

Application of the formalin test to the study of orofacial pain in the rat

1989 • 197 citations

Formalin induces biphasic activity in C-fibers in the rat

1996 • 184 citations

Dissociation between antinociceptive and anti-inflammatory effects of acetylsalicylic acid and indomethacin in the formalin test

1986 • 177 citations

Persistent cardiovascular and behavioral nociceptive responses to subcutaneous formalin require peripheral nerve input

1995 • 175 citations

Opiates suppress carrageenan-induced edema and hyperthermia at doses that inhibit hyperalgesia

1990 • 148 citations

Neurogenic and tissue-mediated components of formalin-induced edema: Evidence for supraspinal regulation

1991 • 143 citations

Antinociceptive effect of meloxicam, in neurogenic and inflammatory nociceptive models in mice

1998 • 140 citations

Opioid agonists and antagonists: An evaluation of their peripheral actions in inflammation

1992 • 139 citations

Opioid control of the function of primary afferent substance P fibres

1985 • 139 citations

Peripheral opioid modulation of pain and inflammation in the formalin test

1995 • 113 citations

Calcitonin gene-related peptide: Vasoactive effects and potential therapeutic role

1996 • 97 citations

Effects of Preemptive or Postinjury Intrathecal Local Anesthesia on Persistent Nociceptive Responses in Rats

1996 • 69 citations

Studies on the acute inflammatory response. I. Involvement of the central nervous system in certain models of inflammation.

1968 • 62 citations

Early nociceptive events influence the temporal profile, but not the magnitude, of the tonic response to subcutaneous formalin: effects with remifentanil.

1997 • 47 citations

Pharmacological evidence for the involvement of the endogenous opioid system in the response to local inflammation in the rat paw

1995 • 46 citations

μ- and κ-opioid receptor agonists produce peripheral inhibition of neurogenic plasma extravasation in rat skin

1993 • 43 citations

δ- and κ-opioid agonists inhibit plasma extravasation induced by bradykinin in the knee joint of the rat

1992 • 38 citations

Involvement of β-endorphin in the modulation of paw inflammatory edema in the rat

1996 • 37 citations

Intraplantar morphine depresses spinal c‐Fos expression induced by carrageenin inflammation but not by noxious heat

1996 • 29 citations

Similar Effects of Acetylsalicylic Acid and Morphine on Immediate Responses to Acute Noxious Stimulation

1987 • 26 citations

Continuous intravenous infusion of naloxone does not change behavioral, cardiovascular, or inflammatory responses to subcutaneous formalin in the rat

1997 • 19 citations

Dynorphin A(6-12) Analogs Suppress Thermal Edema

1998 • 10 citations

Potent inhibition of thermal edema in rat by des-Tyr-dynorphin A

1995 • 3 citations