Antinociceptive effects after intrathecal administration of phosphodiester-, 2′-O-allyl-, and C-5-propyne-modified antisense oligodeoxynucleotides targeting the NMDAR1 subunit in mouse

Cloned Glutamate Receptors

1994 • 3,989 citations

Molecular Diversity of Glutamate Receptors and Implications for Brain Function

1992 • 2,535 citations

Heteromeric NMDA Receptors: Molecular and Functional Distinction of Subtypes

1992 • 2,527 citations

The formalin test: an evaluation of the method

1992 • 2,414 citations

The Role of Glutamate Neurotoxicity in Hypoxic-Ischemic Neuronal Death

1990 • 2,204 citations

Intrathecal morphine in mice: A new technique

1980 • 1,880 citations

Molecular cloning and characterization of the rat NMDA receptor

1991 • 1,780 citations

A new method for receptor autoradiography: [3H]Opioid receptors in rat brain

1979 • 797 citations

Gene inhibition using antisense oligodeoxynucleotides

1994 • 746 citations

Characterization of oligonucleotide transport into living cells.

1989 • 739 citations

Cationic lipids enhance cellular uptake and activity of phosphorothioate antisense oligonucleotides.

1992 • 609 citations

Zinc potentiates agonist-lnduced currents at certain splice variants of the NMDA receptor

1993 • 605 citations

The chemical excitation of spinal neurones by certain acidic amino acids

1960 • 484 citations

The differential expression of 16 NMDA and non-NMDA receptor subunits in the rat spinal cord and in periaqueductal gray

1993 • 435 citations

Antisense Gene Inhibition by Oligonucleotides Containing C-5 Propyne Pyrimidines

1993 • 405 citations

Ligand affinities at recombinant receptors depend on subunit composition

1994 • 381 citations

Antisense oligodeoxynucleotides to NMDA-R1 receptor channel protect cortical neurons from excitotoxicity and reduce focal ischaemic infarctions

1993 • 374 citations

PHARMACOKINETICS AND ANALGESIC EFFECT OF KETAMINE IN MAN

1981 • 315 citations

Glutamate, excitotoxicity and amyotrophic lateral sclerosis

1997 • 294 citations

Antisense oligonucleotide strategies in neuropharmacology

1994 • 265 citations

Does antisense exist?

1995 • 257 citations

DNA binding to human leukocytes. Evidence for a receptor-mediated association, internalization, and degradation of DNA.

1985 • 240 citations

Complement Activation and Hemodynamic Changes Following Intravenous Administration of Phosphorothioate Oligonucleotides in the Monkey

1994 • 240 citations

Actions of glutamic acid on spinal neurones

1973 • 234 citations

Selective loss of δ opioid analgesia and binding by antisense oligodeoxynucleotides to a δ opioid receptor

1994 • 192 citations

Distinct spatiotemporal expressions of five NMDA receptor channel subunit mRNAs in the cerebellum

1994 • 183 citations

Antinociceptive actions of different classes of excitatory amino acid receptor antagonists in mice

1992 • 177 citations

Dynamics of the internalization of phosphodiester oligodeoxynucleotides in HL60 cells

1993 • 172 citations

The behavioural effects of an N-methylaspartate receptor antagonist following application to the lumbar spinal cord of conscious rats

1984 • 172 citations

Comparison of ketamine and pethidine in experimental and postoperative pain

1989 • 148 citations

Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model

1991 • 145 citations

Distinct distributions of five NMDA receptor channel subunit mRNAs in the brainstem

1994 • 133 citations

The formalin test in mice: the influence of ambient temperature

1991 • 132 citations

Distinct spatiotemporal distributions of the N‐Methyl‐<scp>D</scp>‐aspartate receptor channel subunit mRNAs in the mouse cervical cord

1994 • 128 citations

Clinical Experience with Oral Ketamine

1999 • 115 citations

Site and Mechanism of Antisense Inhibition by C-5 Propyne Oligonucleotides

1995 • 95 citations

Thalamic NMDA receptors modulate inflammation-produced hyperalgesia in the rat

1997 • 78 citations

Ketamine in cancer pain: an update.

1996 • 75 citations

Dextromethorphan suppresses both formalin-induced nociceptive behavior and the formalin-induced increase in spinal cord c- fos mRNA

1995 • 75 citations

Distinct gene expression of the N- receptor channel subunit in peripheral neurons of the mouse sensory ganglia and adrenal gland

1994 • 66 citations

The NMDA antagonist 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) has antinociceptive effect after intrathecal injection in the rat

1994 • 66 citations

Alternatively spliced isoforms of the N-methyl-d-aspartate receptor subunit 1 are differentially distributed within the rat spinal cord

1994 • 62 citations

Delivery of antisense oligonucleotides by poly(L-lysine) conjugation and liposome encapsulation.

1993 • 59 citations

Comparison of Ketamine and Dextromethorphan in Potentiating the Antinociceptive Effect of Morphine in Rats

1998 • 56 citations

Pharmacological Studies of Grooming and Scratching Behavior Elicited by Spinal Substance P and Excitatory Amino Acidsa

1988 • 55 citations

Effects of oligonucleotide length, mismatches and mRNA levels on C-5 propyne-modified antisense potency

1996 • 50 citations

Phosphorothioate BCR-ABL antisense oligonucleotides induce cell death, but fail to reduce cellular bcr-abl protein levels.

1995 • 48 citations

Pretreatment with antisense oligodeoxynucleotides directed against the NMDA-R1 receptor enhances survival and behavioral recovery following traumatic brain injury in rats

1995 • 48 citations

Spinal cord morphology and antinociception after chronic intrathecal administration of excitatory amino acid antagonists in the rat

1993 • 47 citations

Proof of Mechanism of Antisense Drugs

1996 • 43 citations

Effects of a partial agonist and a full antagonist acting at the glycine site of the NMDA receptor on inflammation‐induced mechanical hyperalgesia in rats

1996 • 41 citations

Comparison of Ketamine and Dextromethorphan in Potentiating the Antinociceptive Effect of Morphine in Rats

1998 • 35 citations

Knock down of spinal NMDA receptors reduces NMDA and formalin evoked behaviors in rat

2000 • 33 citations

In VivoPharmacokinetics of Phosphorothioate Oligonucleotides Containing Contiguous Guanosines

1997 • 31 citations

Rapid turnover rate of the hippocampal synaptic NMDA-R1 receptor subunits

1994 • 26 citations

Use of subunit-specific antisense oligodeoxynucleotides to define developmental changes in the properties of N-methyl-D-aspartate receptors.

1996 • 16 citations

Differential effects of intrastriatally infused fully and endcap phosphorothioate antisense oligonucleotides on morphology, histochemistry and prodynorphin expression in rat brain

2000 • 7 citations

Section Review: Biologicals &amp; Immunologicals: Applications of antisense technology to both basic and clinical research

1995 • 4 citations