Long-term modulation of mitochondrial Ca2+ signals by protein kinase C isozymes

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Down-Regulation of Na⁺/K⁺ATPase Activity by Human Parvovirus B19 Capsid Protein VP1

2013 • 8,607 citations

The versatility and universality of calcium signalling

2000 • 5,407 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

Mitochondrial control of cell death

2000 • 3,098 citations

Close Contacts with the Endoplasmic Reticulum as Determinants of Mitochondrial Ca ²⁺ Responses

1998 • 2,130 citations

Calcium signaling

1995 • 1,905 citations

High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria

1997 • 1,695 citations

The extended protein kinase C superfamily

1998 • 1,544 citations

Mitochondria and calcium: from cell signalling to cell death

2000 • 1,192 citations

Molecular and cellular physiology of intracellular calcium stores

1994 • 1,132 citations

Decoding of cytosolic calcium oscillations in the mitochondria

1995 • 1,090 citations

Reducing the Environmental Sensitivity of Yellow Fluorescent Protein

2001 • 1,013 citations

Protein kinase C - a question of specificity

1994 • 958 citations

Rapid changes of mitochondrial Ca2+ revealed by specifically targeted recombinant aequorin

1992 • 920 citations

Regulation of mitochondrial ATP synthesis by calcium: Evidence for a long-term metabolic priming

1999 • 776 citations

Protein Kinase C as a Molecular Machine for Decoding Calcium and Diacylglycerol Signals

1998 • 646 citations

Multiple pathways control protein kinase C phosphorylation

2000 • 598 citations

The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action

2001 • 578 citations

A Critical Evaluation

1964 • 577 citations

Mitochondria as all‐round players of the calcium game

2000 • 556 citations

Apoptosis driven by IP3-linked mitochondrial calcium signals

1999 • 492 citations

A Functional Role for Mitochondrial Protein Kinase Cα in Bcl2 Phosphorylation and Suppression of Apoptosis

1998 • 446 citations

Protein kinase C isozymes and substrates

1996 • 440 citations

The Golgi apparatus is an inositol 1,4,5-trisphosphate-sensitive Ca2+ store, with functional properties distinct from those of the endoplasmic reticulum

1998 • 431 citations

Active mitochondria surrounding the pancreatic acinar granule region prevent spreading of inositol trisphosphate-evoked local cytosolic Ca2+ signals

1999 • 362 citations

Transfected Aequorin in the Measurement of Cytosolic Ca2+ Concentration ([Ca2+]c)

1995 • 361 citations

Protein kinase C modulation of NMDA currents: an important link for LTP induction

1992 • 350 citations

Signaling through protein kinase C

1998 • 326 citations

Mitochondrial Ca2+ homeostasis in intact cells.

1994 • 320 citations

Monitoring dynamic changes in free Ca2+ concentration in the endoplasmic reticulum of intact cells.

1995 • 308 citations

Immunocytochemical Localization of Eight Protein Kinase C Isozymes Overexpressed in NIH 3T3 Fibroblasts

1995 • 302 citations

Mitochondrial Translocation of Protein Kinase C δ in Phorbol Ester-induced Cytochrome c Release and Apoptosis

2000 • 301 citations

Mitochondria Suppress Local Feedback Activation of Inositol 1,4,5-Trisphosphate Receptors by Ca2+

1999 • 261 citations

Stable Interactions between Mitochondria and Endoplasmic Reticulum Allow Rapid Accumulation of Calcium in a Subpopulation of Mitochondria

2003 • 225 citations

Differential Localization of Protein Kinase C δ by Phorbol Esters and Related Compounds Using a Fusion Protein with Green Fluorescent Protein

1999 • 184 citations

Mitochondrial Ca2+ Uptake Depends on the Spatial and Temporal Profile of Cytosolic Ca2+ Signals

2001 • 183 citations

Activation Mechanisms of Protein Kinase C: Maturation, Catalytic Activation, and Targeting

2002 • 148 citations

Glucose-stimulated insulin secretion correlates with changes in mitochondrial and cytosolic Ca2+ in aequorin-expressing INS-1 cells.

1996 • 144 citations

Dynamics of [Ca2+] in the Endoplasmic Reticulum and Cytoplasm of Intact HeLa Cells

1997 • 142 citations

Recombinant aequorin and green fluorescent protein as valuable tools in the study of cell signalling

2001 • 134 citations

NF‐κB activation by protein kinase C isoforms and B‐cell function

2003 • 121 citations

The protein kinase C and protein kinase C related gene families

1995 • 119 citations

Effects of PMCA and SERCA pump overexpression on the kinetics of cell Ca2+ signalling

2000 • 113 citations

Opposing effects of protein kinase C and protein kinase A on metabotropic glutamate receptor signaling: Selective desensitization of the inositol trisphosphate/Ca ²⁺ pathway by phosphorylation of the receptor-G protein-coupling domain

2000 • 110 citations

Protein Kinase C-ζ and Phosphoinositide-dependent Protein Kinase-1 Are Required for Insulin-induced Activation of ERK in Rat Adipocytes

1999 • 107 citations

Ca2+ influx–independent synaptic potentiation mediated by mitochondrial Na+-Ca2+ exchanger and protein kinase C

2003 • 103 citations

Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation.

1994 • 93 citations

Synthetic hispidin, a PKC inhibitor, is more cytotoxic toward cancer cells than normal cells in vitro.

1997 • 90 citations

Differential Translocation of Protein Kinase C ε during HeLa Cell Adhesion to a Gelatin Substratum

1996 • 87 citations

Recombinant aequorin and green fluorescent protein as valuable tools in the study of cell signalling

2001 • 82 citations

[30] Photoprotein-mediated measurement of calcium ion concentration in mitochondria of living cells

1995 • 79 citations

Biphasic Insulin Release as the Expression of Combined Inhibitory and Potentiating Effects of Glucose*

1987 • 70 citations

Desensitization of Mitochondrial Ca2+ and Insulin Secretion Responses in the Beta Cell

1998 • 66 citations

Decoding of Short-lived Ca2+ Influx Signals into Long Term Substrate Phosphorylation through Activation of Two Distinct Classes of Protein Kinase C

2003 • 64 citations

Possible role of reactive oxygen species in antiviral defense.

1998 • 59 citations

Inhibition of inositol 1,4,5-trisphosphate-induced Ca2+ release in permeabilized pancreatic acinar cells by hormonal and phorbol ester pretreatment

1989 • 53 citations

Molecular cloning of a cDNA for the human inositol 1,4,5-trisphosphate receptor type 1, and the identification of a third alternatively spliced variant

1995 • 52 citations

Protein kinases A and C phosphorylate purified Ca2+-ATPase from rat cortex, cerebellum and hippocampus1A preliminary report of the PKA- and PKC-mediated phosphorylation of Ca2+-ATPase purified from rat brain was presented at the FEBS Special Meeting: Cell Signalling Mechanisms, Amsterdam, The Netherlands, June 29–July 3, 1997.1

1998 • 36 citations

Spontaneous Autophosphorylation of Lyn Tyrosine Kinase at both Its Activation Segment and C-Terminal Tail Confers Altered Substrate Specificity^,

1998 • 33 citations

Modulation of Histamine-induced Ca2+ Release by Protein Kinase C

2003 • 31 citations

Fast Reversibility of Glucose-Induced Desensitization in Rat Pancreatic Islets: Evidence for an Involvement of Ionic Fluxes

1996 • 26 citations

Mitochondrial Calcium Oscillations in C2C12 Myotubes

2001 • 24 citations

Differential localisation of nPKCδ during cell cycle progression

2002 • 9 citations