Synthetic hispidin, a PKC inhibitor, is more cytotoxic toward cancer cells than normal cells in vitro.

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Platinum Compounds: a New Class of Potent Antitumour Agents

1969 • 3,785 citations

Protein kinase C and lipid signaling for sustained cellular responses

1995 • 2,527 citations

Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

1986 • 2,445 citations

One Hundred and Twenty-Seven Cultured Human Tumor Cell Lines Producing Tumors in Nude Mice23

1977 • 1,556 citations

Adriamycin

1974 • 1,051 citations

Characteristics of a Human Diploid Cell Designated MRC-5

1970 • 593 citations

The Protein Phosphatases Involved in Cellular Regulation. 1. Classification and Substrate Specificities

1983 • 471 citations

Studies on Fluorinated Pyrimidines

1961 • 419 citations

Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyrosine kinase activity.

1986 • 275 citations

Synthesis and biological evaluation of 2-styrylquinazolin-4(3H)-ones, a new class of antimitotic anticancer agents which inhibit tubulin polymerization

1990 • 257 citations

Binding of cis - and trans -Dichlorodiammineplatinum(II) to DNA: Evidence for Unwinding and Shortening of the Double Helix

1979 • 254 citations

Cross-linking of Complementary Strands of DNA in Mammalian Cells by Antitumour Platinum Compounds

1972 • 245 citations

Multiple pathway signal tran sduction by the cAMP‐dependent protein kinase

1994 • 241 citations

Differential effects of flavonoids as inhibitors of tyrosine protein kinases and serine/threonine protein kinases

1988 • 193 citations

Signal-Transduction Therapy. A Novel Approach to Disease Management

1994 • 188 citations

Differential inhibition of the products of the human alkaline phosphatase loci

1978 • 163 citations

Mechanism of inhibition of microtubule polymerization by colchicine: inhibitory potencies of unliganded colchicine and tubulin-colchicine complexes

1992 • 137 citations

Signal‐Transduction Therapy

1994 • 129 citations

Human pancreatic adenocarcinoma line Capan-1 in tissue culture and the nude mouse: morphologic, biologic, and biochemical characteristics.

1982 • 114 citations

Phenotypic and Genotypic Characteristics of a Cell Line From a Squamous Cell Carcinoma of Human Skin<xref ref-type="fn" rid="fn2">2</xref>

1982 • 90 citations

Involvement of protein kinase C in the regulation of assembly-disassembly of neurofilaments in vitro

1990 • 81 citations

The physiological disposition of 5-fluorouracil in mice bearing solid L1210 lymphocytic leukemia.

1972 • 78 citations

Design of potent protein kinases inhibitors using the bisubstrate approach

1991 • 74 citations

Environmental modulation of the expression of differentiation and malignancy in six human squamous cell carcinoma cell lines.

1985 • 74 citations

An update on the biochemistry of 5-fluorouracil

1981 • 68 citations

Protein kinase C activates chloride conductance in C127 cells stably expressing the cystic fibrosis gene

1993 • 51 citations

The discovery of protein phosphatases: From chaos and confusion to an understanding of their role in cell regulation and human disease

1994 • 41 citations

The expression of carbonic anhydrases II and IV in the human pancreatic cancer cell line (Capan 1) is associated with bicarbonate ion channels

1994 • 40 citations

Mechanism of colchicine binding to tubulin. Tolerance of substituents in ring C' of biphenyl analogs

1991 • 40 citations

983. Constituents of the higher fungi. Part I. Hispidin, a new 4-hydroxy-6-styryl-2-pyrone from polyporus hispidus(Bull.) Fr.

1961 • 39 citations

Introduction: Protein Kinases

1994 • 38 citations

Regulation of Prostaglandin E2 synthesis in human amnion by protein kinase C

1990 • 31 citations

Noninvasive fluorine-19 NMR study of fluoropyrimidine metabolism in cell cultures of human pancreatic and colon adenocarcinoma

1986 • 27 citations

New mechanism of action of the cancer chemotherapeutic agent 5-fluorouracil in human cells.

1994 • 26 citations

Evidence for involvement of protein kinase C in regulation of intracellular pH by Cl−/HCO 3 − antiport

1991 • 18 citations

Calcium phosphate deposits in domes of human pancreatic adenocarcinoma (Capan‐1) cell cultures

1990 • 14 citations

Regulation of phospholipid hydrolysis and second messenger formation by protein kinase C

1992 • 14 citations

984. Constituents of the higher fungi. Part II. The synthesis of hispidin

1961 • 13 citations

Differential sensitivity of pancreatic adenocarcinoma cell lines to chemotherapeutic agents in culture.

1983 • 11 citations

Enzymatic studies of the effect of Cu (II) on oxygen radical production stimulated by daunorubicin and ametantrone

1990 • 5 citations