The Mechanism of Action of FK‐506 and Cyclosporin A

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

Cyclophilin: A Specific Cytosolic Binding Protein for Cyclosporin A

1984 • 1,670 citations

Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

1989 • 1,414 citations

A receptor for the immuno-suppressant FK506 is a cis–trans peptidyl-prolyl isomerase

1989 • 1,376 citations

Cyclosporine

1989 • 1,340 citations

FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro.

1987 • 1,209 citations

Contingent Genetic Regulatory Events in T Lymphocyte Activation

1989 • 1,108 citations

Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin

1989 • 1,087 citations

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

1991 • 1,054 citations

A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

1989 • 1,010 citations

FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin

1992 • 865 citations

Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A.

1992 • 811 citations

Calcineurin: a calcium- and calmodulin-binding protein of the nervous system.

1979 • 724 citations

Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin.

1990 • 699 citations

Cyclosporin A, FK-506, and Rapamycin: Pharmacologic Probes of Lymphocyte Signal Transduction

1992 • 675 citations

The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes.

1989 • 667 citations

Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin.

1990 • 613 citations

FK506 binding protein associated with the calcium release channel (ryanodine receptor).

1992 • 525 citations

T-Cell Proliferation Involving the CD28 Pathway Is Associated witH Cyclosporine-Resistant Interleukin 2 Gene Expression

1987 • 522 citations

Transmission of Signals from the T Lymphocyte Antigen Receptor to the Genes Responsible for Cell Proliferation and Immune Function: The Missing Link

1990 • 517 citations

The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SW15

1991 • 501 citations

Cyclosporine for Plaque-Type Psoriasis

1991 • 427 citations

Novel immunosuppressive agent, FK506. In vitro effects on the cloned T cell activation.

1987 • 416 citations

Two cytoplasmic candidates for immunophilin action are revealed by affinity for a new cyclophilin: One in the presence and one in the absence of CsA

1991 • 399 citations

T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression.

1987 • 354 citations

Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence.

1991 • 319 citations

Substrate specificities of the peptidyl prolyl cis-trans isomerase activities of cyclophilin and FK-506 binding protein: evidence for the existence of a family of distinct enzymes

1990 • 303 citations

NF-ATp, a T lymphocyte DNA-binding protein that is a target for calcineurin and immunosuppressive drugs.

1993 • 293 citations

The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin.

1992 • 254 citations

Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes.

1992 • 252 citations

Is cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A?

1991 • 248 citations

Sensitivity to cyclosporin A is mediated by cyclophilin in Neurospora crassa and Saccharomyces cerevisiae

1989 • 220 citations

Functional domain structure of calcineurin A: mapping by limited proteolysis

1989 • 201 citations

Calcium channel regulation by calcineurin, a Ca2+-activated phosphatase in mammalian brain

1989 • 195 citations

Calcineurin mediates alpha-adrenergic stimulation of Na+,K(+)-ATPase activity in renal tubule cells.

1992 • 191 citations

The cyclophilin multigene family of peptidyl-prolyl isomerases. Characterization of three separate human isoforms.

1991 • 187 citations

The non-DNA-binding heterooligomeric form of mammalian steroid hormone receptors contains a hsp90-bound 59-kilodalton protein.

1990 • 174 citations

Molecular cloning of a membrane-associated human FK506- and rapamycin-binding protein, FKBP-13.

1991 • 173 citations

The Hsp56 component of steroid receptor complexes binds to immobilized FK506 and shows homology to FKBP-12 and FKBP-13.

1992 • 170 citations

Limited Duration of Remission of Insulin Dependency in Children With Recent Overt Type I Diabetes Treated With Low-Dose Cyclosporin

1990 • 168 citations

Cyclosporin-mediated inhibition of bovine calcineurin by cyclophilins A and B.

1992 • 168 citations

An immunophilin that binds M(r) 90,000 heat shock protein: main structural features of a mammalian p59 protein.

1992 • 168 citations

Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain.

1989 • 163 citations

A novel secreted cyclophilin-like protein (SCYLP)

1991 • 138 citations

FK-506, a potent novel immunosuppressive agent, binds to a cytosolic protein which is distinct from the cyclosporin A-binding protein, cyclophilin.

1989 • 137 citations

Rapamycin and FK506 binding proteins (immunophilins)

1991 • 136 citations

The cytosolic-binding protein for the immunosuppressant FK-506 is both a ubiquitous and highly conserved peptidyl-prolyl cis-trans isomerase.

1990 • 133 citations

A rapamycin-selective 25-kDa immunophilin

1992 • 130 citations

Isolation and characterization of a 40-kDa cyclophilin-related protein.

1992 • 125 citations

Immunophilin ligands demonstrate common features of signal transduction leading to exocytosis or transcription.

1991 • 123 citations

Characterization of a cDNA clone encoding the calmodulin-binding domain of mouse brain calcineurin.

1988 • 115 citations

Characterization of high molecular weight FK-506 binding activities reveals a novel FK-506-binding protein as well as a protein complex.

1992 • 113 citations

A cyclophilin-related protein involved in the function of natural killer cells.

1993 • 112 citations

Structural and evolutionary relationships among the immunophilins: two ubiquitous families of peptidyl‐prolyl cis‐trans isomerases

1992 • 111 citations

The complete primary structure of calcineurin A, a calmodulin binding protein homologous with protein phosphatases 1 and 2A

1989 • 108 citations

FK-506 and cyclosporin A inhibit highly similar signal transduction pathways in human T lymphocytes

1991 • 105 citations

Nephron segment-specific inhibition of Na+/K+-ATPase activity by cyclosporin A

1993 • 100 citations

A rapid and sensitive method for detection and quantification of calcineurin and calmodulin-binding proteins using biotinylated calmodulin.

1985 • 98 citations

FKB1 encodes a nonessential FK 506-binding protein in Saccharomyces cerevisiae and contains regions suggesting homology to the cyclophilins.

1991 • 98 citations

Evidence for a second isoform of the catalytic subunit of calmodulin-dependent protein phosphatase (calcineurin A)

1989 • 88 citations

Characterization of the human cyclophilin gene and of related processed pseudogenes

1990 • 84 citations

Molecular cloning of a calmodulin-dependent phosphatase from murine testis: identification of a developmentally expressed nonneural isoenzyme.

1992 • 84 citations

Molecular cloning of a 25-kDa high affinity rapamycin binding protein, FKBP25.

1992 • 82 citations

Rabbit FKBP59-heat shock protein binding immunophillin (HBI) is a calmodulin binding protein

1992 • 80 citations

Effects of cyclosporin A and FK506 on Fc epsilon receptor type I-initiated increases in cytokine mRNA in mouse bone marrow-derived progenitor mast cells: resistance to FK506 is associated with a deficiency in FK506-binding protein FKBP12.

1992 • 68 citations

Molecular cloning and chromosomal mapping of the human gene for the testis-specific catalytic subunit of calmodulin-dependent protein phosphatase (calcineurin A)

1992 • 63 citations

On the localization of FKBP25 in T‐lymphocytes

1993 • 45 citations

FK-506 and cyclosporin a: Selective inhibition of calcium ionophore-induced polymorphonuclear leukocyte degranulation

1991 • 38 citations

Identification of a third alternatively spliced cDNA encoding the catalytic subunit of protein phosphatase 2Bβ

1991 • 37 citations

Isolation of a human cDNA encoding a 25 kDa FK-506 and rapamycin binding protein

1992 • 26 citations

Cyclosporin A Inhibits Late Steps of T Lymphocyte Activation after Transmembrane Signaling1

1987 • 25 citations

Chromosomal mapping of the human genes for the calmodulindependent protein phosphatase (calcineurin) catalytic subunit

1991 • 23 citations

T lymphocyte activation through the C28 pathway is insensitive to inhibition by the immunosuppressive drug FK-506

1989 • 18 citations

Modulation of calcineurin phosphotyrosyl protein phosphatase activity by calmodulin and protease treatment

1986 • 17 citations

Deleted Work

1955 • 0 citations