The specific fates of tight junction proteins in apoptotic epithelial cells

The biochemistry of apoptosis

2000 • 7,314 citations

Occludin: a novel integral membrane protein localizing at tight junctions.

1993 • 2,466 citations

Multifunctional strands in tight junctions

2001 • 2,392 citations

Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin

1998 • 2,005 citations

Size-selective loosening of the blood-brain barrier in claudin-5–deficient mice

2003 • 1,705 citations

Organelle-specific initiation of cell death pathways

2001 • 1,454 citations

Claudin-based tight junctions are crucial for the mammalian epidermal barrier

2002 • 1,412 citations

Junctional Adhesion Molecule, a Novel Member of the Immunoglobulin Superfamily That Distributes at Intercellular Junctions and Modulates Monocyte Transmigration

1998 • 1,356 citations

Proteases to die for

1998 • 1,241 citations

Paracellin-1, a Renal Tight Junction Protein Required for Paracellular Mg ²⁺ Resorption

1999 • 1,107 citations

A Single Gene Product, Claudin-1 or -2, Reconstitutes Tight Junction Strands and Recruits Occludin in Fibroblasts

1998 • 923 citations

Nuclear localization of β-catenin by interaction with transcription factor LEF-1

1996 • 864 citations

Signalling to and from tight junctions

2003 • 863 citations

Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein.

1996 • 849 citations

Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells

2002 • 769 citations

Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions

1999 • 739 citations

Conversion of Zonulae Occludentes from Tight to Leaky Strand Type by Introducing Claudin-2 into Madin-Darby Canine Kidney I Cells

2001 • 704 citations

Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis

1999 • 587 citations

Claudins create charge-selective channels in the paracellular pathway between epithelial cells

2002 • 530 citations

A Synthetic Peptide Corresponding to the Extracellular Domain of Occludin Perturbs the Tight Junction Permeability Barrier

1997 • 527 citations

Neutrophil Transmigration in Inflammatory Bowel Disease Is Associated with Differential Expression of Epithelial Intercellular Junction Proteins

2001 • 497 citations

Caspase-3 Is Required for α-Fodrin Cleavage but Dispensable for Cleavage of Other Death Substrates in Apoptosis

1998 • 484 citations

The tight junction protein ZO-1 and an interacting transcription factor regulate ErbB-2 expression

2000 • 437 citations

Mutations in the Gene Encoding Tight Junction Claudin-14 Cause Autosomal Recessive Deafness DFNB29

2001 • 436 citations

Differential expression of matrix metalloproteinases and their tissue inhibitors in colon mucosa of patients with inflammatory bowel disease

2000 • 382 citations

Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture

2003 • 377 citations

Tumor necrosis factor-alpha (TNFα) regulates the epithelial barrier in the human intestinal cell line HT-29/B6

1999 • 367 citations

Claudin-based barrier in simple and stratified cellular sheets

2002 • 355 citations

Matrix metalloproteinase levels are elevated in inflammatory bowel disease

1999 • 321 citations

APOPTOSIS OF CRYPT EPITHELIAL CELLS IN ULCERATIVE COLITIS

1996 • 299 citations

Expression from the human occludin promoter is affected by tumor necrosis factor α and interferon γ

2000 • 276 citations

Claudin-8 Expression in Madin-Darby Canine Kidney Cells Augments the Paracellular Barrier to Cation Permeation

2003 • 273 citations

Occludin confers adhesiveness when expressed in fibroblasts

1997 • 272 citations

Cleavage and Shedding of E-cadherin after Induction of Apoptosis

2001 • 269 citations

Microfilament reorganization during apoptosis: the role of Gas2, a possible substrate for ICE-like proteases.

1995 • 265 citations

Cleavage of β-Catenin and Plakoglobin and Shedding of VE-Cadherin during Endothelial Apoptosis: Evidence for a Role for Caspases and Metalloproteinases

1998 • 264 citations

Novel Paracellin-1 Mutations in 25 Families with Familial Hypomagnesemia with Hypercalciuria and Nephrocalcinosis

2001 • 262 citations

The transmembrane protein occludin of epithelial tight junctions is a functional target for serine peptidases from faecal pellets of Dermatophagoides pteronyssinus

2001 • 251 citations

CD95 (APO-1/Fas)-mediated apoptosis in colon epithelial cells: A possible role in ulcerative colitis

1997 • 249 citations

Divergent induction of apoptosis and IL-8 secretion in HT-29 cells in response to TNF-alpha and ligation of Fas antigen.

1995 • 248 citations

Epithelial barrier defects in ulcerative colitis: Characterization and quantification by electrophysiological imaging

2001 • 245 citations

Leaks in the epithelial barrier caused by spontaneous and TNF‐α‐induced single‐cell apoptosis

2000 • 245 citations

Dismantling Cell–Cell Contacts during Apoptosis Is Coupled to a Caspase-dependent Proteolytic Cleavage of β-Catenin

1997 • 232 citations

Permeability barrier dysfunction in transgenic mice overexpressing claudin 6

2002 • 229 citations

Dynamic behavior of paired claudin strands within apposing plasma membranes

2003 • 221 citations

Increased secretion of pro-inflammatory cytokines by circulating polymorphonuclear neutrophils and regulation by interleukin 10 during intestinal inflammation

1998 • 214 citations

Distinct effects of Vibrio cholerae haemagglutinin/protease on the structure and localization of the tight junction-associated proteins occludin and ZO-1

2000 • 188 citations

Tissue cytokine and chemokine expression in inflammatory bowel disease

2001 • 180 citations

Tight Junction, a Platform for Trafficking and Signaling Protein Complexes

2000 • 175 citations

Occludin proteolysis and increased permeability in endothelial cells through tyrosine phosphatase inhibition

1999 • 171 citations

Apoptosis-induced Cleavage of β-Catenin by Caspase-3 Results in Proteolytic Fragments with Reduced Transactivation Potential

2000 • 148 citations

The Fate of Desmosomal Proteins in Apoptotic Cells

2001 • 134 citations

Modulation of barrier function during Fas-mediated apoptosis in human intestinal epithelial cells

2000 • 133 citations

Molecular complexity of vertebrate tight junctions (Review)

2002 • 113 citations

Permeability of human HT‐29/B6 colonic epithelium as a function of apoptosis

2001 • 108 citations

The rat mucosal mast cell chymase, RMCP-11, alters epithelial cell monolayer permeability in association with altered distribution of the tight junction proteins ZO-1 and occludin

1998 • 106 citations

Truncation Mutants of the Tight Junction Protein ZO-1 Disrupt Corneal Epithelial Cell Morphology

2000 • 77 citations

Proteolytic processing of the adherens junctions components β-catenin and γ-catenin/plakoglobin during apoptosis

1998 • 71 citations

The fate of E- and P-cadherin during the early stages of apoptosis

1999 • 62 citations

mRTVP-1, a Novel p53 Target Gene with Proapoptotic Activities

2002 • 61 citations

Expression from the human occludin promoter is affected by tumor necrosis factor alpha and interferon gamma

2000 • 58 citations

Activation of Monocytes during Inflammatory Bowel Disease

1991 • 39 citations

Apoptosis: Implications for Inflammatory Bowel Disease

2000 • 38 citations

Specific cleavage of γ catenin by caspases during apoptosis

1998 • 28 citations

Maintaining a defense as the injured leave the field: Apoptosis and barrier function in the intestine

2000 • 6 citations