Hedgehog signaling is required for pituitary gland development

The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary.

1996 • 1,208 citations

The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo

1995 • 1,175 citations

Pax6 Controls Progenitor Cell Identity and Neuronal Fate in Response to Graded Shh Signaling

1997 • 1,019 citations

An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis

2000 • 847 citations

Compartment boundaries and the control of Drosopfiffa limb pattern by hedgehog protein

1994 • 842 citations

Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism

1996 • 787 citations

Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling

1999 • 773 citations

Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein

1999 • 772 citations

Sonic hedgehog signaling is essential for hair development

1998 • 742 citations

Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation

2000 • 704 citations

Pituitary cell phenotypes involve cell-specific Pit-1 mRNA translation and synergistic interactions with other classes of transcription factors.

1990 • 636 citations

Sonic hedgehog regulates branching morphogenesis in the mammalian lung

1998 • 631 citations

Notochord repression of endodermal Sonic hedgehog permits pancreas development

1998 • 621 citations

Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis

1997 • 561 citations

Morphogens, Compartments, and Pattern: Lessons from Drosophila?

1996 • 559 citations

Morphogenesis

1999 • 491 citations

Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing

1995 • 489 citations

Essential Role forSonic hedgehogduring Hair Follicle Morphogenesis

1999 • 489 citations

Multistep signaling requirements for pituitary organogenesis in vivo

1998 • 478 citations

Specification of Pituitary Cell Lineages by the LIM Homeobox Gene Lhx3

1996 • 445 citations

Ptx1, a bicoid-related homeo box transcription factor involved in transcription of the pro-opiomelanocortin gene.

1996 • 419 citations

Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary

1998 • 388 citations

Multistep Control of Pituitary Organogenesis

1997 • 378 citations

Sonic hedgehogRegulates Proliferation and Inhibits Differentiation of CNS Precursor Cells

1999 • 360 citations

Formation of Rathke’s pouch requires dual induction from the diencephalon

1998 • 320 citations

Reciprocal Interactions of Pit1 and GATA2 Mediate Signaling Gradient–Induced Determination of Pituitary Cell Types

1999 • 319 citations

In situ hybridization analysis of anterior pituitary hormone gene expression during fetal mouse development.

1994 • 314 citations

Comparative synteny cloning of zebrafish you-too: mutations in the Hedgehog target gli2 affect ventral forebrain patterning

1999 • 292 citations

Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development

2000 • 285 citations

Structure and Expression of the Rat mRNA Encoding a Novel Member of the Fibroblast Growth Factor Family

1996 • 285 citations

P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development.

1996 • 270 citations

Pancreas development is promoted by cyclopamine, a Hedgehog signaling inhibitor

1998 • 256 citations

Gli proteins and Hedgehog signaling: development and cancer

1999 • 249 citations

A model for anteroposterior patterning of the vertebrate limb based on sequential long- and short-range Shh signalling and Bmp signalling

2000 • 217 citations

Compartment boundaries: at the edge of development

1999 • 205 citations

Sonic Hedgehog induces proliferation of committed skeletal muscle cells in the chick limb

1998 • 179 citations

Cell-specific expression of the prolactin gene in transgenic mice is controlled by synergistic interactions between promoter and enhancer elements.

1989 • 176 citations

Expression of the Sonic hedgehog (SHH) Gene during Early Human Development and Phenotypic Expression of New Mutations Causing Holoprosencephaly

1999 • 158 citations

Pax6 is essential for establishing ventral-dorsal cell boundaries in pituitary gland development

1999 • 155 citations

Early steps in pituitary organogenesis

1999 • 153 citations

A new function of BMP4: dual role for BMP4 in regulation of Sonic hedgehog expression in the mouse tooth germ

2000 • 150 citations

The hypothalamic-pituitary axis; co-development of two organs

1996 • 150 citations

Brain 4: a novel mammalian POU domain transcription factor exhibiting restricted brain-specific expression.

1992 • 145 citations

Genealogy of the Anterior Pituitary Gland: Tracing a Family Tree

1999 • 95 citations

New players and puzzles in the Hedgehog signaling pathway

1998 • 93 citations

NKX2 gene expression in neuroectoderm but not in mesendodermally derived structures depends on sonic hedgehog in mouse embryos

2000 • 92 citations

Enhancer-mediated high level expression of mouse pituitary glycoprotein hormone alpha-subunit transgene in thyrotropes, gonadotropes, and developing pituitary gland.

1994 • 87 citations

Combinatorial codes in signaling and synergy: lessons from pituitary development

1999 • 66 citations