Systemic levels of cytokines and GAD-specific autoantibodies isotypes in Chinese IDDM patients

Human TH1 and TH2 subsets: doubt no more

1991 • 1,103 citations

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1993 • 1,087 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1993 • 962 citations

Interleukin-12 and its role in the generation of TH1 cells

1993 • 869 citations

Extreme Th1 bias of invariant Vα24JαQ T cells in type 1 diabetes

1998 • 642 citations

IL-12: Initiation Cytokine for Cell-Mediated Immunity

1993 • 583 citations

Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes.

1996 • 428 citations

Immunoregulatory and Cytokine Imbalances in the Pathogenesis of IDDM: Therapeutic Intervention by Immunostimulation?

1994 • 363 citations

Epitope specificity, cytokine production profile and diabetogenic activity of insulin‐specific T cell clones isolated from NOD mice

1995 • 359 citations

IFN-gamma stimulates IgG2a secretion by murine B cells stimulated with bacterial lipopolysaccharide.

1988 • 308 citations

Interleukin 4 induces synthesis of IgE and IgG4 in human B cells

1989 • 300 citations

Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes–prone mice

1996 • 266 citations

Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes

1993 • 247 citations

Elevated serum levels of macrophage-derived cytokines precede and accompany the onset of IDDM

1996 • 196 citations

Transgenic plants expressing autoantigens fed to mice to induce oral immune tolerance

1997 • 180 citations

Interleukin-10 induces immunoglobulin G isotype switch recombination in human CD40-activated naive B lymphocytes.

1996 • 173 citations

T-Cell Responses to Autoantigens in IDDM: The Search for the Holy Grail

1996 • 164 citations

Immunization With the Larger Isoform of Mouse Glutamic Acid Decarboxylase (GAD67) Prevents Autoimmune Diabetes in NOD Mice

1994 • 128 citations

Systemic Bias of Cytokine Production Toward Cell-Mediated Immune Regulation in IDDM and Toward Humoral Immunity in Graves' Disease

1997 • 124 citations

Decreased IL-4 production in new onset type I insulin-dependent diabetes mellitus.

1996 • 115 citations

Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM. Therapeutic intervention by immunostimulation?

1994 • 112 citations

Interleukin-10 is expressed by bovine type 1 helper, type 2 helper, and unrestricted parasite-specific T-cell clones and inhibits proliferation of all three subsets in an accessory-cell-dependent manner

1994 • 97 citations

Are CD4⁺ T_h1 cells pro-inflammatory or anti-inflammatory? The ratio of IL-10 to IFN-_γ or IL-2 determines their function

1995 • 86 citations

Human monoclonal islet cell antibodies from a patient with insulin-dependent diabetes mellitus reveal glutamate decarboxylase as the target antigen.

1992 • 81 citations

Cytokines in sera from insulin-dependent diabetic patients at diagnosis

1991 • 78 citations

Serum Levels of Tumor Necrosis Factor and IL-1α and IL-1β in Diabetic Patients

1991 • 77 citations

Cytokine Gene Expression in Pancreatic Islet-Infiltrating Leukocytes of BB Rats: Expression of Th1 Cytokines Correlates With β-Cell Destructive Insulitis and IDDM

1996 • 74 citations

Anti-GAD antibodies in Chinese patients with youth and adult-onset IDDM and NIDDM

1997 • 56 citations

Regulation of the interaction between Th1 and Th2 T cell clones to provide help for antibody production in vivo

1995 • 56 citations

Cytokine gene expression in pancreatic islet-infiltrating leukocytes of BB rats: expression of Th1 cytokines correlates with beta-cell destructive insulitis and IDDM

1996 • 53 citations

Th1 and Th2 cells in autoimmunity

1995 • 52 citations

Immunization with the larger isoform of mouse glutamic acid decarboxylase (GAD67) prevents autoimmune diabetes in NOD mice

1994 • 49 citations

T-cell responses to autoantigens in IDDM. The search for the Holy Grail

1996 • 48 citations

Immunoglobulin isotype production by cycling human B lymphocytes in response to recombinant cytokines and anti-IgM.

1990 • 42 citations

Systemic bias of cytokine production toward cell-mediated immune regulation in IDDM and toward humoral immunity in Graves' disease

1997 • 40 citations

IgG subclass antibodies to glutamic acid decarboxylase and risk for progression to clinical insulin-dependent diabetes

1998 • 38 citations

Immunoglobulin variable gene analysis of human autoantibodies reveals antigen‐driven immune response to glutamate decarboxylase in type 1 diabetes mellitus

1995 • 29 citations

Characterization of islet cell antibody in insulin dependent diabetes: evidence for IgG1 subclass restriction and polyclonality.

1988 • 26 citations

Cytokine production in patients with newly diagnosed insulin‐dependent (type I) diabetes mellitus

1988 • 26 citations

Polyclonal Nature of Islet Cell Antibodies in Insulin-Dependent Diabetes

1988 • 25 citations

Evidence that Th1 Lymphocytes Predominate in Islet Inflammation and Thyroiditis in the BioBreeding (BB) Rat

1996 • 23 citations

Cytokine plasma levels and lymphocyte subsets in patients with newly diagnosed insulin-dependent (type 1) diabetes mellitus before and following initial insulin treatment

1993 • 21 citations

Human islet cell antibodies: immunoglobulin class and subclass distribution defined by monoclonal antibodies.

1987 • 14 citations

Insulin-Secretory-Granule Specific T Cell Clones in Human IDDM

1995 • 12 citations

Low interleukin-2 synthesis by type 1 diabetics is regulated at the pretranslational level

1991 • 9 citations

In Vitro Stimulation with Glutamic Acid Decarboxylase (GAD65) Leads to an Oligoclonal Response of Peripheral T‐Cells in an IDDM Patient

1995 • 9 citations

HLA-DR-restricted T cell lines from newly diagnosed type 1 diabetic patients specific for insulinoma and normal islet beta cell proteins: lack of reactivity to glutamic acid decarboxylase

1995 • 8 citations

Soluble T-Cell Markers and Serum Cytokines in Type I (Insulin-Dependent) Diabetes mellitus

1995 • 2 citations

Non-Restricted Immunoglobulin-G Subclass Islet Cell Antibodies in Chinese

1993 • 2 citations