Low interleukin-2 synthesis by type 1 diabetics is regulated at the pretranslational level

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene

1985 • 1,836 citations

Type I Diabetes Mellitus

1986 • 1,615 citations

Disorders of motility and muscle tone with special reference to the corpus striatum

1925 • 1,408 citations

Cytoplasmic dot hybridization. Simple analysis of relative mRNA levels in multiple small cell or tissue samples.

1982 • 1,333 citations

The Interleukin-2 T-Cell System: A New Cell Growth Model

1984 • 935 citations

Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester

1985 • 753 citations

Effects of Cyclosporine Immunosuppression in Insulin-Dependent Diabetes Mellitus of Recent Onset

1984 • 555 citations

Multiple actions of interleukin 6 within a cytokine network

1988 • 536 citations

Interleukin 2

1984 • 497 citations

Recurrent diabetes mellitus in the pancreas iso- and allograft. A light and electron microscopic and immunohistochemical analysis of four cases.

1985 • 387 citations

B cell stimulatory factor 1 (interleukin 4) is a potent costimulant for normal resting T lymphocytes.

1987 • 251 citations

Protein kinase C and calcium ion in mitogenic response of macrophage-depleted human peripheral lymphocytes.

1985 • 220 citations

Acquired Defect in Interleukin-2 Production in Patients with Type I Diabetes Mellitus

1986 • 129 citations

T-cell growth factor: complete nucleotide sequence and organization of the gene in normal and malignant cells.

1984 • 113 citations

Decreased Synthesis of Interleukin-2 (IL-2) in Insulin-dependent Diabetes Mellitus

1984 • 113 citations

Tumor promoters in conjunction with calcium ionophores mimic antigenic stimulation by reactivation of alloantigen-primed murine T lymphocytes.

1985 • 83 citations

Characterization and partial purification of a specific interleukin 2 inhibitor.

1985 • 78 citations

Mechanisms of autoimmunity in insulin-dependent diabetes mellitus.

1988 • 64 citations

Interleukin 2 and Soluble Interleukin 2–Receptor Secretion Defect In Vitro in Newly Diagnosed Type I Diabetic Patients

1989 • 50 citations

Decreased synthesis of interleukin-2 (IL-2) in insulin-dependent diabetes mellitus

1984 • 47 citations

Basis for the Probit Analysis of an Interferon Plaque Reduction Assay

1972 • 40 citations

Regulation of HLA-DR, DP, and DQ expression in activated T cells

1988 • 34 citations

Interleukin 2 and soluble interleukin 2-receptor secretion defect in vitro in newly diagnosed type I diabetic patients

1989 • 27 citations

PARTIAL PRESERVATION OF PANCREATIC β-CELL FUNCTION IN CHILDREN WITH DIABETES

1981 • 25 citations

Pretreatment of cloned helper T lymphocytes with IL-2 induces unresponsiveness to antigen and concanavalin A, associated with decreased inositol phosphate and diacylglycerol production.

1989 • 10 citations