Unravelling the biology of macrophage infection by gene expression profiling of intracellular Salmonella enterica

Cluster analysis and display of genome-wide expression patterns

1998 • 16,410 citations

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

2001 • 3,507 citations

Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines

1981 • 2,042 citations

The COG database: new developments in phylogenetic classification of proteins from complete genomes

2001 • 1,841 citations

Complete genome sequence of Salmonella enterica serovar Typhimurium LT2

2001 • 1,829 citations

Simultaneous Identification of Bacterial Virulence Genes by Negative Selection

1995 • 1,202 citations

Killing activity of neutrophils is mediated through activation of proteases by K+ flux

2002 • 1,141 citations

Mutants of Salmonella typhimurium that cannot survive within the macrophage are avirulent.

1986 • 1,116 citations

The Pleiotropic Two-Component Regulatory System PhoP-PhoQ

2001 • 849 citations

Identification of a virulence locus encoding a second type III secretion system in Salmonella typhimurium.

1996 • 793 citations

DNA Microarray-Mediated Transcriptional Profiling of the Escherichia coli Response to Hydrogen Peroxide

2001 • 782 citations

Roles of the Glutathione- and Thioredoxin-Dependent Reduction Systems in the Escherichia Coli and Saccharomyces Cerevisiae Responses to Oxidative Stress

2000 • 681 citations

Selection of Bacterial Virulence Genes That Are Specifically Induced in Host Tissues

1993 • 671 citations

Identification of a pathogenicity island required for Salmonella survival in host cells.

1996 • 656 citations

Macrophage‐dependent induction of the Salmonella pathogenicity island 2 type III secretion system and its role in intracellular survival

1998 • 615 citations

Genes encoding putative effector proteins of the type III secretion system of Salmonella pathogenicity island 2 are required for bacterial virulence and proliferation in macrophages

1998 • 596 citations

Fluorescence-Based Isolation of Bacterial Genes Expressed Within Host Cells

1997 • 593 citations

Salmonella maintains the integrity of its intracellular vacuole through the action of SifA

2000 • 583 citations

Mechanisms of acid resistance in enterohemorrhagic Escherichia coli

1996 • 563 citations

A Salmonella Locus that Controls Resistance to Microbicidal Proteins from Phagocytic Cells

1989 • 556 citations

Regulation of Lipid A Modifications by Salmonella typhimurium Virulence Genes phoP-phoQ

1997 • 553 citations

Antimicrobial Actions of the Nadph Phagocyte Oxidase and Inducible Nitric Oxide Synthase in Experimental Salmonellosis. I. Effects on Microbial Killing by Activated Peritoneal Macrophages in Vitro

2000 • 526 citations

Murine Salmonellosis Studied by Confocal Microscopy: Salmonella typhimurium Resides Intracellularly Inside Macrophages and Exerts a Cytotoxic Effect on Phagocytes In Vivo

1997 • 489 citations

Effects of Environment on Compensatory Mutations to Ameliorate Costs of Antibiotic Resistance

2000 • 457 citations

Twelve Species of the Nucleoid-associated Protein from Escherichia coli

1999 • 454 citations

Salmonella typhimurium activates virulence gene transcription within acidified macrophage phagosomes.

1992 • 441 citations

Salmonella typhimurium deletion mutants lacking adenylate cyclase and cyclic AMP receptor protein are avirulent and immunogenic

1987 • 434 citations

pathogenicity islands: big virulence in small packages

2000 • 432 citations

Antimicrobial Actions of the Nadph Phagocyte Oxidase and Inducible Nitric Oxide Synthase in Experimental Salmonellosis. II. Effects on Microbial Proliferation and Host Survival in Vivo

2000 • 401 citations

Periplasmic superoxide dismutase protectsSalmonellafrom products of phagocyte NADPH-oxidase and nitric oxide synthase

1997 • 386 citations

Genetic and Functional Analysis of a PmrA-PmrB-Regulated Locus Necessary for Lipopolysaccharide Modification, Antimicrobial Peptide Resistance, and Oral Virulence of Salmonella enterica Serovar Typhimurium

2000 • 383 citations

Control of bacterial DNA supercoiling

1992 • 372 citations

A Signal Transduction System that Responds to Extracellular Iron

2000 • 360 citations

Intracellular trafficking in Mycobacterium tuberculosis and Mycobacterium avium-infected macrophages.

1994 • 358 citations

Environmental regulation of Salmonella pathogenicity island 2 gene expression

1999 • 353 citations

Salmonella Pathogenicity Island 2 Mediates Protection of Intracellular Salmonella from Reactive Nitrogen Intermediates

2002 • 349 citations

Molecular analysis of spv virulence genes of the salmonella virulence plasmids

1993 • 325 citations

A PhoP-Regulated Outer Membrane Protease of Salmonella enterica Serovar Typhimurium Promotes Resistance to Alpha-Helical Antimicrobial Peptides

2000 • 313 citations

Acidification of phagosomes containing Salmonella typhimurium in murine macrophages

1996 • 312 citations

Flavorubredoxin, an Inducible Catalyst for Nitric Oxide Reduction and Detoxification in Escherichia coli

2002 • 298 citations

Regulation of polymyxin resistance and adaptation to low-Mg2+ environments

1997 • 281 citations

EmrR is a negative regulator of the Escherichia coli multidrug resistance pump EmrAB

1995 • 271 citations

Breaking through the acid barrier: An orchestrated response to proton stress by enteric bacteria

2001 • 260 citations

Methylglyoxal production in bacteria: suicide or survival?

1998 • 249 citations

Transcriptional autoregulation of the Salmonella typhimurium phoPQ operon

1995 • 243 citations

The Alternative Sigma Factor, ς ^E , Is Critically Important for the Virulence of Salmonella typhimurium

1999 • 236 citations

Over 1000 genes are involved in the DNA damage response of Escherichia coli

2002 • 225 citations

Salmonella Pathogenicity Island 2-Encoded Type III Secretion System Mediates Exclusion of NADPH Oxidase Assembly from the Phagosomal Membrane

2001 • 223 citations

The pef fimbrial operon of Salmonella typhimurium mediates adhesion to murine small intestine and is necessary for fluid accumulation in the infant mouse

1996 • 214 citations

Aerobic-anaerobic gene regulation in Escherichia coli: control by the ArcAB and Fnr regulons

1994 • 209 citations

Peptide methionine sulfoxide reductase fromEscherichia coliandMycobacterium tuberculosisprotects bacteria against oxidative damage from reactive nitrogen intermediates

2001 • 199 citations

Multiple Fimbrial Adhesins Are Required for Full Virulence of Salmonella typhimurium in Mice

1998 • 186 citations

Internal pH crisis, lysine decarboxylase and the acid tolerance response of Salmonella typhimurium

1996 • 186 citations

Magnesium transport in Salmonella typhimurium: 28Mg2+ transport by the CorA, MgtA, and MgtB systems

1989 • 184 citations

Recombination‐deficient mutants of Salmonella typhimurium are avirulent and sensitive to the oxidative burst of macrophages

1993 • 180 citations

Salmonella effectors within a single pathogenicity island are differentially expressed and translocated by separate type III secretion systems

2002 • 177 citations

Cyclic AMP and its receptor protein negatively regulate the coordinate expression of cholera toxin and toxin-coregulated pilus in Vibrio cholerae

1997 • 177 citations

How Intracellular Bacteria Survive: Surface Modifications That Promote Resistance to Host Innate Immune Responses

1999 • 174 citations

Immunity to Systemic Salmonella Infections

2002 • 171 citations

Growth of Francisella tularensis LVS in macrophages: the acidic intracellular compartment provides essential iron required for growth

1995 • 171 citations

Contribution of fimbrial operons to attachment to and invasion of epithelial cell lines by Salmonella typhimurium

1996 • 169 citations

SitABCD Is the Alkaline Mn²⁺Transporter ofSalmonella entericaSerovar Typhimurium

2002 • 165 citations

Polynucleotide phosphorylase is a global regulator of virulence and persistency in Salmonella enterica

2002 • 163 citations

Flavohemoglobin Hmp ProtectsSalmonella entericaSerovar Typhimurium from Nitric Oxide-Related Killing by Human Macrophages

2002 • 161 citations

Evaluation of Salmonella typhimurium strains harbouring defined mutations in htrA and aroA in the murine salmonellosis model

1992 • 157 citations

Antimicrobial proteins of murine macrophages

1993 • 153 citations

The Thioredoxin Superfamily: Redundancy, Specificity, and Gray-Area Genomics

1999 • 146 citations

A Proteinaceous Gene Regulatory Thermometer in Salmonella

1997 • 145 citations

Oxygen-dependent anti-Salmonella activity of macrophages

2001 • 139 citations

Unravelling the mysteries of virulence gene regulation in Salmonella typhimurium

2000 • 136 citations

Ubiquicidin, a novel murine microbicidal protein present in the cytosolic fraction of macrophages

1999 • 133 citations

A Salmonella protein that is required for resistance to antimicrobial peptides and transport of potassium.

1994 • 133 citations

Microarrays for microbiologists

2001 • 132 citations

Peptide methionine sulfoxide reductase contributes to the maintenance of adhesins in three major pathogens.

1996 • 132 citations

Fur regulon of Salmonella typhimurium: identification of new iron-regulated genes

1995 • 129 citations

Coordinate Intracellular Expression of Salmonella Genes Induced during Infection

1999 • 128 citations

Role of Salmonella typhimurium Mn-superoxide dismutase (SodA) in protection against early killing by J774 macrophages

1995 • 125 citations

A role for the PhoP/Q regulon in inhibition of fusion between lysosomes and Salmonella-containing vacuoles in macrophages

2001 • 121 citations

-induced macrophage death: the role of caspase-1 in death and inflammation

2001 • 121 citations

Salmonella typhimurium Virulence Genes Are Induced upon Bacterial Invasion into Phagocytic and Nonphagocytic Cells

1999 • 116 citations

Mu d-directed lacZ fusions regulated by low pH in Escherichia coli

1987 • 102 citations

Regulation of the Salmonella typhimuriumFlavohemoglobin Gene

1998 • 101 citations

The natural resistance-associated macrophage protein 1 Slc11a1 (formerly Nramp1) and iron metabolism in macrophages

2002 • 97 citations

Proteomic detection of PhoPQ- and acid-mediated repression ofSalmonella motility

2001 • 97 citations

Release of lipopolysaccharide from intracellular compartments containing Salmonella typhimurium to vesicles of the host epithelial cell

1997 • 93 citations

The ability of Salmonella typhimurium to produce the siderophore enterobactin is not a virulence factor in mouse typhoid

1985 • 90 citations

Decreased Expression of Specific Genes in Yeast Cells Lacking Histone H1

2001 • 87 citations

Hha Is a Negative Modulator of Transcription ofhilA, theSalmonella entericaSerovar Typhimurium Invasion Gene Transcriptional Activator

2001 • 87 citations

Salmonella typhimurium mutants that downregulate phagocyte nitric oxide production

2000 • 80 citations

intracellular proliferation: where, when and how?

2001 • 78 citations

Isolation and characterization of Salmonella typhimurium and Yersinia pseudotuberculosis-containing phagosomes from infected mouse macrophages: Y. pseudotuberculosis traffics to terminal lysosomes where they are degraded

1998 • 72 citations

Magnesium transport in Salmonella typhimurium: regulation of mgtA and mgtCB during invasion of epithelial and macrophage cells

1998 • 72 citations

Differential accumulation of Salmonella[Cu, Zn] superoxide dismutases SodCI and SodCII in intracellular bacteria: correlation with their relative contribution to pathogenicity

2002 • 71 citations

The Escherichia coli genome sequence: the end of an era or the start of the FUN?

1997 • 62 citations

Microarray analysis of bacterial pathogenicity

2002 • 59 citations

Physical interactions between DinI and RecA nucleoprotein filament for the regulation of SOS mutagenesis

2001 • 57 citations

The spv virulence operon of Salmonella typhimurium LT2 is regulated negatively by the cyclic AMP (cAMP)-cAMP receptor protein system

1994 • 51 citations

Magnesium transport in Salmonella typhimurium: biphasic magnesium and time dependence of the transcription of the mgtA and mgtCB loci

1998 • 49 citations

Use of transcriptional fusions to monitor gene expression: a cautionary tale

1994 • 49 citations

Macrophage control of Brucella abortus: influence of cytokines and iron

1993 • 41 citations

RpoS Synthesis Is Growth Rate Regulated in Salmonella typhimurium, but Its Turnover Is Not Dependent on Acetyl Phosphate Synthesis or PTS Function

1999 • 37 citations

Dynamics of growth and death within aSalmonella typhimuriumpopulation during infection of macrophages

1997 • 36 citations

A new alpha-helical coiled coil protein encoded by the Salmonella typhimurium virulence plasmid.

1992 • 35 citations

DNA topology and adaptation of salmonella typhimurium to an intracellular environment

2000 • 30 citations

The RNA Chain Elongation Rate of the λ Late mRNA Is Unaffected by High Levels of ppGpp in the Absence of Amino Acid Starvation

1996 • 30 citations

It's easy to build your own microarrayer!

2001 • 26 citations

Control of Lipoprotein Lipase Secretion by Macrophages: Effect of Macrophage Differentiation Agents

1990 • 23 citations

LacZ-promoter fusions: the effect of growth

2002 • 14 citations

Induction of SOS response in Salmonella typhimurium TA4107/pSK1002 by peroxynitrite-generating agent, N-morpholino sydnonimine

2002 • 11 citations

Construction and characterization of two lexA mutants of Salmonella typhimurium with different UV sensitivities and UV mutabilities

1996 • 10 citations

Expression of the rfa , LPS Biosynthesis Promoter in Salmonella typhimurium During Invasion of Intestinal Epithelial Cells

2000 • 10 citations

DNA TOPOLOGY AND ADAPTATION OF SALMONELLA TYPHIMURIUM TO AN INTRACELLULAR ENVIRONMENT

2001 • 7 citations

Expression of Salmonella typhimurium virulence plasmid genes in cultured macrophages.

1993 • 6 citations