Cyclic AMP and its receptor protein negatively regulate the coordinate expression of cholera toxin and toxin-coregulated pilus in Vibrio cholerae

A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR

1988 • 2,150 citations

Experiments with gene fusions

1985 • 1,210 citations

Use of phoA gene fusions to identify a pilus colonization factor coordinately regulated with cholera toxin.

1987 • 1,041 citations

[31] Analysis and construction of stable phenotypes in gram-negative bacteria with Tn5- and Tn10-derived minitransposons

1994 • 887 citations

Construction of a broad host range cosmid cloning vector and its use in the genetic analysis of Rhizobium mutants

1982 • 857 citations

A general method for site-directed mutagenesis in prokaryotes

1981 • 697 citations

Cholera toxin genes: nucleotide sequence, deletion analysis and vaccine development

1983 • 645 citations

Cholera toxin transcriptional activator ToxR is a transmembrane DNA binding protein

1987 • 626 citations

Cyclic AMP in prokaryotes.

1992 • 509 citations

Positive selection vectors for allelic exchange

1996 • 459 citations

Regulatory cascade controls virulence in Vibrio cholerae.

1991 • 451 citations

Salmonella typhimurium deletion mutants lacking adenylate cyclase and cyclic AMP receptor protein are avirulent and immunogenic

1987 • 434 citations

Duplication and amplification of toxin genes in Vibrio cholerae

1983 • 395 citations

Synthesis of cholera toxin is positively regulated at the transcriptional level by toxR.

1984 • 320 citations

Toxin-coregulated pilus, but not mannose-sensitive hemagglutinin, is required for colonization by Vibrio cholerae O1 El Tor biotype and O139 strains

1996 • 320 citations

Cyclic AMP in prokaryotes

1992 • 310 citations

Characterization of the Vibrio cholerae ToxR regulon: identification of novel genes involved in intestinal colonization

1988 • 304 citations

Molecular cloning and nucleotide sequencing of the gene for E. coli cAMP receptor protein

1982 • 283 citations

Culture Conditions for Stimulating Cholera Toxin Production byVibrio choleraeO1 El Tor

1986 • 270 citations

Broad-host-range vectors for delivery of TnphoA: use in genetic analysis of secreted virulence determinants of Vibrio cholerae

1989 • 257 citations

Requirement of Adenosine 3′, 5′-Cyclic Phosphate for Flagella Formation in Escherichia coli and Salmonella typhimurium

1970 • 200 citations

The amino‐terminal part of ActA is critical for the actin‐based motility of Listeria monocytogenes; the central proline‐rich region acts as a stimulator

1995 • 146 citations

Differential expression of the ToxR regulon in classical and E1 Tor biotypes of Vibrio cholerae is due to biotype-specific control over toxT expression.

1996 • 113 citations

Single amino acid substitutions in the N‐terminus of Vibrio cholerae TcpA affect colonization, autoagglutination, and serum resistance

1995 • 110 citations

Transcription of the Escherichia coli adenylate cyclase gene is negatively regulated by cAMP-cAMP receptor protein.

1985 • 107 citations

Organization of tcp, acf, and toxT genes within a ToxT‐dependent operon

1995 • 95 citations

Properties of adenyl cyclase and cyclic adenosine 3',5'-monophosphate receptor protein-deficient mutants of Escherichia coli

1976 • 90 citations

Upstream activating sequences that are shared by two divergently transcribed operons mediate cAMP‐CRP regulation of pilus‐adhesin in Escherichia coli

1989 • 89 citations

Avirulent Salmonella typhimurium Δcya Δcrp oral vaccine strains expressing a streptococcal colonization and virulence antigen

1988 • 86 citations

[41] Regulation of cholera toxin by temperature, pH, and osmolarity

1994 • 83 citations

Localization of protective epitopes within the pilin subunit of the Vibrio cholerae toxin-coregulated pilus

1991 • 73 citations

Advances in research on cholera and related diarrheas

1990 • 69 citations

The spv virulence operon of Salmonella typhimurium LT2 is regulated negatively by the cyclic AMP (cAMP)-cAMP receptor protein system

1994 • 51 citations

General Transduction in Vibrio cholerae

1981 • 40 citations

Cholera vaccines: fighting an ancient scourge

1994 • 36 citations

Cyclic AMP and the production of sex pili by E. coli K-12 carrying derepressed sex factors

1975 • 34 citations

Comparison of the promoter proximal regions of the toxin-co-regulated tcp gene cluster in classical and E1 Tor strains of Vibrio cholerae O1

1996 • 30 citations

Cyclic-AMP-dependent switch in initiation of transcription from the two promoters of the Escherichia coli gal operon: identification and assay of 5'-triphosphate ends of mRNA by GTP:RNA guanyltransferase

1989 • 30 citations

Catabolite repression of Escherichia coli heat-stable enterotoxin activity

1981 • 29 citations

Mechanism of CRP-mediated cya suppression in Escherichia coli

1983 • 29 citations

Regulation of tcp genes in classical and E1 Tor strains of Vibrio cholerae O1

1995 • 23 citations

Adenosine 3′,5′-Cyclic Monophosphate-Deficient Mutants of Vibrio cholerae

1974 • 18 citations

Adenosine 3',5'-cyclic monophosphate in Vibrio cholerae

1975 • 12 citations

Cited By (0)

Loading...