Antimicrobial Actions of the Nadph Phagocyte Oxidase and Inducible Nitric Oxide Synthase in Experimental Salmonellosis. II. Effects on Microbial Proliferation and Host Survival in Vivo

A SIMPLE METHOD OF ESTIMATING FIFTY PER CENT ENDPOINTS12

1938 • 19,183 citations

A simple method of estimating 50 per cent end points

1938 • 8,381 citations

Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines

1981 • 2,042 citations

Altered immune responses in mice lacking inducible nitric oxide synthase

1995 • 1,296 citations

Mutants of Salmonella typhimurium that cannot survive within the macrophage are avirulent.

1986 • 1,116 citations

Perspectives series: host/pathogen interactions. Mechanisms of nitric oxide-related antimicrobial activity.

1997 • 1,109 citations

Natural resistance to infection with intracellular parasites: Isolation of a candidate for Bcg

1993 • 1,107 citations

Mouse model of X–linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production

1995 • 920 citations

Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death.

1995 • 585 citations

Antimicrobial Actions of the Nadph Phagocyte Oxidase and Inducible Nitric Oxide Synthase in Experimental Salmonellosis. I. Effects on Microbial Killing by Activated Peritoneal Macrophages in Vitro

2000 • 526 citations

Phenotype of Mice and Macrophages Deficient in Both Phagocyte Oxidase and Inducible Nitric Oxide Synthase

1999 • 512 citations

Murine Salmonellosis Studied by Confocal Microscopy: Salmonella typhimurium Resides Intracellularly Inside Macrophages and Exerts a Cytotoxic Effect on Phagocytes In Vivo

1997 • 489 citations

Mechanisms of nitric oxide-related antimicrobial activity

1997 • 439 citations

Salmonella typhimurium aroA- infection in gene-targeted immunodeficient mice: major role of CD4+ TCR-alpha beta cells and IFN-gamma in bacterial clearance independent of intracellular location.

1996 • 397 citations

Periplasmic superoxide dismutase protectsSalmonellafrom products of phagocyte NADPH-oxidase and nitric oxide synthase

1997 • 386 citations

Cytokines acting on or secreted by macrophages during intracellular infection (IL-10, IL-12, IFN-γ)

1997 • 349 citations

Vaccines and cell-mediated immunity

1974 • 336 citations

Inducible nitric oxide synthase‐deficient mice have enhanced leukocyte–endothelium interactions in endotoxemia

1997 • 298 citations

Incidence, severity, and prevention of infections in chronic granulomatous disease

1989 • 272 citations

Nitric oxide potentiates hydrogen peroxide-induced killing of Escherichia coli.

1995 • 258 citations

Genetic control of the innate resistance of mice to Salmonella typhimurium: expression of the Ity gene in peritoneal and splenic macrophages isolated in vitro.

1983 • 257 citations

Nitric Oxide and Infection

2002 • 223 citations

A lethal role for lipid A in Salmonella infections

1998 • 210 citations

Interleukin 18 Contributes to Host Resistance and Gamma Interferon Production in Mice Infected with VirulentSalmonella typhimurium

1999 • 206 citations

Natural resistance to Salmonella typhimurium in different inbred mouse strains.

1979 • 204 citations

Role of T cells, TNFα and IFNγ in recall of immunity to oral challenge with virulent salmonellae in mice vaccinated with live attenuated aro− salmonella vaccines

1992 • 201 citations

Superoxide Modulates the Oxidation and Nitrosation of Thiols by Nitric Oxide-derived Reactive Intermediates

1997 • 187 citations

Homocysteine Antagonism of Nitric Oxide-Related Cytostasis in Salmonella typhimurium

1996 • 185 citations

Comparison of the roles of reactive oxygen and nitrogen intermediates in the host response to Mycobacterium tuberculosis using transgenic mice

1997 • 184 citations

Recombination‐deficient mutants of Salmonella typhimurium are avirulent and sensitive to the oxidative burst of macrophages

1993 • 180 citations

Interleukin-12 Is Required for Control of the Growth of Attenuated Aromatic-Compound-Dependent Salmonellae in BALB/c Mice: Role of Gamma Interferon and Macrophage Activation

1998 • 156 citations

Effects of nitric oxide on the induction and differentiation of Th1 cells

1999 • 155 citations

Induction of nitric oxide synthesis and xanthine oxidase and their roles in the antimicrobial mechanism against Salmonella typhimurium infection in mice

1997 • 154 citations

Nitric oxide produced during murine listeriosis is protective

1994 • 148 citations

Capacity of recombinant gamma interferon to activate macrophages for Salmonella-killing activity

1989 • 145 citations

Improved clearance of Mycobacterium avium upon disruption of the inducible nitric oxide synthase gene.

1999 • 130 citations

Effect of interleukin 12 neutralization on host resistance and gamma interferon production in mouse typhoid

1996 • 122 citations

The involvement of tumor necrosis factor in immunity to Salmonella infection.

1991 • 118 citations

In Vivo Blockage of Nitric Oxide with Aminoguanidine Inhibits Immunosuppression Induced by an Attenuated Strain ofSalmonella typhimurium, PotentiatesSalmonellaInfection, and Inhibits Macrophage and Polymorphonuclear Leukocyte Influx into the Spleen

1999 • 116 citations

Endogenous and exogenous interleukin-12 augment the protective immune response in mice orally challenged with Salmonella dublin

1996 • 108 citations

Evaluation of bacterial survival and phagocyte function with a fluorescence-based microplate assay

1997 • 106 citations

Improved Clearance of Mycobacterium avium Upon Disruption of the Inducible Nitric Oxide Synthase Gene

1999 • 104 citations

The crucial role of polymorphonuclear leukocytes in resistance toSalmonella dublininfections in genetically susceptible and resistant mice

1998 • 102 citations

Salmonella typhimurium aroA, htrA, and aroD htrA mutants cause progressive infections in athymic (nu/nu) BALB/c mice

1997 • 98 citations

Susceptibility toSalmonella typhimuriumInfection and Effectiveness of Vaccination in Mice Deficient in the Tumor Necrosis Factor Alpha p55 Receptor

1998 • 96 citations

Effect of anti-tumor necrosis factor alpha antibodies on histopathology of primary Salmonella infections

1995 • 94 citations

Serum TNFα in mouse typhoid and enhancement of a salmonella infection by anti-TNFα antibodies

1991 • 91 citations

IFN-γ-Dependent Nitric Oxide Production Is Not Linked to Resistance in Experimental African Trypanosomiasis

1999 • 71 citations

T cells do not mediate the initial suppression of a Salmonella infection in the RES.

1990 • 65 citations

The initial suppression of bacterial growth in a salmonella infection is mediated by a localized rather than a systemic response

1987 • 64 citations

The in vivo division and death rates of Salmonella typhimurium in the spleens of naturally resistant and susceptible mice measured by the superinfecting phage technique of Meynell.

1980 • 63 citations

NOS2‐derived nitric oxide regulates the size, quantity and quality of granuloma formation in Mycobacterium avium‐infected mice without affecting bacterial loads

1999 • 63 citations

Effect of late administration of anti-TNα antibodies on a Salmonella infection in the mouse model

1993 • 56 citations

T-Cell Responses duringTrypanosoma bruceiInfections in Mice Deficient in Inducible Nitric Oxide Synthase

1999 • 55 citations

Macrophage inflammatory protein-1 alpha production in lipopolysaccharide-stimulated human adherent blood mononuclear cells is inhibited by the nitric oxide synthase inhibitor N(G)-monomethyl-L-arginine.

1997 • 54 citations

Salmonella typhimurium infections in mice deficient in interleukin-4 production: role of IL-4 in infection-associated pathology.

1997 • 37 citations

Stabilization of human neutrophil NADPH oxidase activated in a cell-free system by cytosolic proteins and by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide.

1992 • 34 citations

Oxygen-Dependent Inhibition of Neutrophil Respiratory Burst by Nitric Oxide

1996 • 19 citations