pathogenicity islands: big virulence in small packages

Type III Protein Secretion Systems in Bacterial Pathogens of Animals and Plants

1998 • 2,394 citations

A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens.

1995 • 1,239 citations

Cloning and molecular characterization of genes whose products allow Salmonella typhimurium to penetrate tissue culture cells.

1989 • 988 citations

Supramolecular Structure of the Salmonella typhimurium Type III Protein Secretion System

1998 • 872 citations

Salmonella typhimurium initiates murine infection by penetrating and destroying the specialized epithelial M cells of the Peyer's patches.

1994 • 859 citations

S. typhimurium Encodes an Activator of Rho GTPases that Induces Membrane Ruffling and Nuclear Responses in Host Cells

1998 • 804 citations

Identification of a virulence locus encoding a second type III secretion system in Salmonella typhimurium.

1996 • 793 citations

TheSalmonellainvasin SipB induces macrophage apoptosis by binding to caspase-1

1999 • 748 citations

Identification of a pathogenicity island required for Salmonella survival in host cells.

1996 • 656 citations

Macrophage‐dependent induction of the Salmonella pathogenicity island 2 type III secretion system and its role in intracellular survival

1998 • 615 citations

Salmonella typhimurium invasion induces apoptosis in infected macrophages.

1996 • 601 citations

Genes encoding putative effector proteins of the type III secretion system of Salmonella pathogenicity island 2 are required for bacterial virulence and proliferation in macrophages

1998 • 596 citations

Fluorescence-Based Isolation of Bacterial Genes Expressed Within Host Cells

1997 • 593 citations

Pathogenicity Islands: Bacterial Evolution in Quantum Leaps

1996 • 566 citations

Murine Salmonellosis Studied by Confocal Microscopy: Salmonella typhimurium Resides Intracellularly Inside Macrophages and Exerts a Cytotoxic Effect on Phagocytes In Vivo

1997 • 489 citations

Ruffles induced by Salmonella and other stimuli direct macropinocytosis of bacteria

1993 • 443 citations

SopB, a protein required for virulence of Salmonella dublin , is an inositol phosphate phosphatase

1998 • 436 citations

The YopB protein of Yersinia pseudotuberculosis is essential for the translocation of Yop effector proteins across the target cell plasma membrane and displays a contact-dependent membrane disrupting activity.

1996 • 387 citations

Role of the S. typhimurium Actin-Binding Protein SipA in Bacterial Internalization

1999 • 386 citations

SALMONELLOSIS: Host Immune Responses and Bacterial Virulence Determinants¹

1996 • 385 citations

Salmonella spp. are cytotoxic for cultured macrophages

1996 • 379 citations

A Salmonella virulence protein that inhibits cellular trafficking

1999 • 371 citations

How Salmonella became a pathogen

1997 • 367 citations

The Salmonella selC locus contains a pathogenicity island mediating intramacrophage survival

1997 • 357 citations

Environmental regulation of Salmonella pathogenicity island 2 gene expression

1999 • 353 citations

Cytoskeletal rearrangements accompanying Salmonella entry into epithelial cells

1991 • 349 citations

Salmonella typhi uses CFTR to enter intestinal epithelial cells

1998 • 340 citations

Molecular analysis of spv virulence genes of the salmonella virulence plasmids

1993 • 325 citations

Apoptosis of human intestinal epithelial cells after bacterial invasion.

1998 • 302 citations

The invasion‐associated type III system of Salmonella typhimurium directs the translocation of Sip proteins into the host cell

1997 • 300 citations

A secreted effector protein of Salmonella dublin is translocated into eukaryotic cells and mediates inflammation and fluid secretion in infected ileal mucosa

1997 • 290 citations

Identification of a Salmonella virulence gene required for formation of filamentous structures containing lysosomal membrane glycoproteins within epithelial cells

1996 • 282 citations

Homologs of the Shigella IpaB and IpaC invasins are required for Salmonella typhimurium entry into cultured epithelial cells

1995 • 279 citations

Identification of a pathogenicity island required for Salmonella enteropathogenicity

1998 • 270 citations

Cognate gene clusters govern invasion of host epithelial cells by Salmonella typhimurium and Shigella flexneri.

1993 • 269 citations

The genetic basis of tetrathionate respiration in Salmonella typhimurium

1999 • 248 citations

Salmonella typhimurium loci involved in survival within macrophages

1994 • 247 citations

A secreted protein tyrosine phosphatase with modular effector domains in the bacterial pathogen Salmonella typhimurlum

1996 • 240 citations

Macrophage killing is an essential virulence mechanism of Salmonella typhimurium.

1996 • 239 citations

The Salmonella typhimurium tyrosine phosphatase SptP is translocated into host cells and disrupts the actin cytoskeleton

1998 • 234 citations

Identification of two targets of the type III protein secretion system encoded by the inv and spa loci of Salmonella typhimurium that have homology to the Shigella IpaD and IpaA proteins

1995 • 227 citations

A secreted Salmonella protein with homology to an avirulence determinant of plant pathogenic bacteria

1997 • 218 citations

The SPI-3 Pathogenicity Island of Salmonella enterica

1999 • 212 citations

A substrate of the centisome 63 type III protein secretion system of Salmonella typhimurium is encoded by a cryptic bacteriophage

1998 • 211 citations

Differential Regulation ofSalmonella typhimuriumType III Secreted Proteins by Pathogenicity Island 1 (SPI-1)-Encoded Transcriptional Activators InvF and HilA

1999 • 204 citations

The invasion-associated type-III protein secretion system inSalmonella – a review

1997 • 201 citations

Salmonella SirA is a global regulator of genes mediating enteropathogenesis

1999 • 199 citations

Influence of theSalmonella typhimuriumPathogenicity Island 2 Type III Secretion System on Bacterial Growth in the Mouse

1999 • 197 citations

An invasion-associated Salmonella protein modulates the actin-bundling activity of plastin

1999 • 193 citations

Interaction of Salmonella with host cells through the centisome 63 type III secretion system

1999 • 187 citations

Identification and characterization of a Salmonella typhimurium oxygen-regulated gene required for bacterial internalization

1994 • 173 citations

YopH of Yersinia pseudotuberculosis interrupts early phosphotyrosine signalling associated with phagocytosis

1996 • 168 citations

Functional analysis of ssaJ and the ssaK/U operon, 13 genes encoding components of the type III secretion apparatus of Salmonella Pathogenicity Island 2

1997 • 168 citations

Analysis of proteins synthesized by Salmonella typhimurium during growth within a host macrophage

1993 • 156 citations

The virulence gene cluster of Listeria monocytogenes is also present in Listeria ivanovii, an animal pathogen, and Listeria seeligeri, a nonpathogenic species

1994 • 152 citations

Secreted Effector Proteins of Salmonella dublin Act in Concert To Induce Enteritis

1998 • 150 citations

Virulence plasmids of Salmonella typhimurium and other salmonellae

1990 • 143 citations

The Salmonella dublin virulence plasmid mediates systemic but not enteric phases of salmonellosis in cattle

1995 • 137 citations

The Salmonella virulence plasmid spv genes are required for cytopathology in human monocyte-derived macrophages

2000 • 136 citations

Salmonella invasion of nonphagocytic cells induces formation of macropinosomes in the host cell

1994 • 132 citations

Differential patterns of acquired virulence genes distinguish Salmonella strains

1998 • 131 citations

Characterization of the operon encoding the YpkA Ser/Thr protein kinase and the YopJ protein of Yersinia pseudotuberculosis

1994 • 128 citations

Identification of a Novel Salmonella Invasion Locus Homologous to Shigella ipgDE

1998 • 128 citations

Functional conservation of the Salmonella and Shigella effectors of entry into epithelial cells

1995 • 120 citations

Avirulence GeneavrRxvfromXanthomonas campestrispv.vesicatoriaSpecifies Resistance on Tomato Line Hawaii 7998

1993 • 118 citations

Identification and Sequence Analysis of a 27-Kilobase Chromosomal Fragment Containing a Salmonella Pathogenicity Island Located at 92 Minutes on the Chromosome Map of Salmonella enterica Serovar Typhimurium LT2

1998 • 116 citations

Salmonella typhimurium Virulence Genes Are Induced upon Bacterial Invasion into Phagocytic and Nonphagocytic Cells

1999 • 116 citations

Mutations in Salmonella Pathogenicity Island 2 (SPI2) Genes Affecting Transcription of SPI1 Genes and Resistance to Antimicrobial Agents

1998 • 111 citations

Expression of the Salmonella virulence plasmid gene spvB in cultured macrophages and nonphagocytic cells

1993 • 106 citations

The crucial role of polymorphonuclear leukocytes in resistance toSalmonella dublininfections in genetically susceptible and resistant mice

1998 • 102 citations

At Least Four Percent of the Salmonella typhimurium Genome Is Required for Fatal Infection of Mice

1998 • 101 citations

Molecular and functional analysis indicates a mosaic structure of Salmonella pathogenicity island 2

1999 • 94 citations

Comparative genetics of the inv-spa invasion gene complex of Salmonella enterica

1997 • 85 citations

Analysis of Host Cells Associated with the Spv-Mediated Increased Intracellular Growth Rate ofSalmonella typhimuriumin Mice

1998 • 80 citations

Magnesium transport in Salmonella typhimurium: regulation of mgtA and mgtCB during invasion of epithelial and macrophage cells

1998 • 72 citations

Magnesium and the Role of mgtC in Growth of Salmonella typhimurium

1998 • 68 citations

Comparative Physical and Genetic Maps of the Virulence Plasmids of Salmonella enterica Serovars Typhimurium, Enteritidis, Choleraesuis, and Dublin

1999 • 68 citations

Bacterial invasion: Force feeding by Salmonella

1999 • 67 citations

The Salmonella virulence plasmid enhances Salmonella-induced lysis of macrophages and influences inflammatory responses

1996 • 61 citations

Transcriptional regulation of Salmonella enterica virulence plasmid genes in cultured macrophages

1993 • 52 citations

Type III secretion machines and the pathogenesis of enteric infections caused by Yersinia and Salmonella spp.

1999 • 48 citations

Type III secretion by Salmonella typhimurium does not require contact with a eukaryotic host

1999 • 39 citations

Regulation of the spvR gene of the Salmonella typhimurium virulence plasmid during exponential-phase growth in intracellular salts medium and at stationary phase in L broth

1998 • 30 citations

The virulence plasmid does not contribute to growth of Salmonella in cultured murine macrophages

1992 • 29 citations

Regulation ofspvR, the positive regulatory gene ofSalmonellaplasmid virulence genes

1994 • 21 citations

Cell-Specific Proteins Synthesized bySalmonella typhimurium

1998 • 20 citations

Inhibition ofSalmonella typhimuriumInvasion by Host Cell Expression of Secreted Bacterial Invasion Proteins

1998 • 19 citations