An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics

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1999 • 2,395 citations

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2002 • 1,116 citations

AKAP signalling complexes: focal points in space and time

2004 • 1,055 citations

Cyclic nucleotide research — still expanding after half a century

2002 • 869 citations

Discrete Microdomains with High Concentration of cAMP in Stimulated Rat Neonatal Cardiac Myocytes

2002 • 843 citations

PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization

2003 • 760 citations

Localized Effects of cAMP Mediated by Distinct Routes of Protein Kinase A

2004 • 745 citations

Requirement of a Macromolecular Signaling Complex for β Adrenergic Receptor Modulation of the KCNQ1-KCNE1 Potassium Channel

2002 • 702 citations

Novel Single Chain cAMP Sensors for Receptor-induced Signal Propagation

2004 • 665 citations

Association of Protein Kinase A and Protein Phosphatase 2B with a Common Anchoring Protein

1995 • 615 citations

Coordination of Three Signaling Enzymes by AKAP79, a Mammalian Scaffold Protein

1996 • 557 citations

Spatially Resolved Dynamics of cAMP and Protein Kinase A Subunits in Aplysia Sensory Neurons

1993 • 549 citations

The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways

2005 • 542 citations

cAMP-Dependent Regulation of Cardiac L-Type Ca2+ Channels Requires Membrane Targeting of PKA and Phosphorylation of Channel Subunits

1997 • 511 citations

Regulation of NMDA Receptors by an Associated Phosphatase-Kinase Signaling Complex

1999 • 497 citations

Targeting of Cyclic AMP Degradation to β ₂ -Adrenergic Receptors by β-Arrestins

2002 • 496 citations

mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module

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Cyclic AMP-specific PDE4 Phosphodiesterases as Critical Components of Cyclic AMP Signaling

2003 • 486 citations

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1996 • 406 citations

cAMP compartmentation is responsible for a local activation of cardiac Ca2+ channels by beta-adrenergic agonists.

1996 • 373 citations

Anchoring of protein kinase A is required for modulation of AMPA/kainate receptors on hippocampal neurons

1994 • 371 citations

RETRACTED: β-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates β-adrenoceptor switching from G _s to G _i

2003 • 363 citations

Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain.

1992 • 350 citations

A novel lipid-anchored A-kinase Anchoring Protein facilitates cAMP-responsive membrane events

1998 • 283 citations

A uniform extracellular stimulus triggers distinct cAMP signals in different compartments of a simple cell

2001 • 282 citations

Cyclic Nucleotide–Gated Channels Colocalize with Adenylyl Cyclase in Regions of Restricted Camp Diffusion

2000 • 266 citations

The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579

1999 • 263 citations

Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein

1997 • 254 citations

Protein Kinase A-anchoring Inhibitor Peptides Arrest Mammalian Sperm Motility

1997 • 250 citations

Phosphodiesterase 4D and Protein Kinase A Type II Constitute a Signaling Unit in the Centrosomal Area

2001 • 240 citations

AKAP-Lbc Anchors Protein Kinase A and Nucleates Gα12-selective Rho-mediated Stress Fiber Formation

2001 • 229 citations

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2005 • 211 citations

Dynamic Complexes of β2-Adrenergic Receptors with Protein Kinases and Phosphatases and the Role of Gravin

1999 • 208 citations

RNA Silencing Identifies PDE4D5 as the Functionally Relevant cAMP Phosphodiesterase Interacting with βArrestin to Control the Protein Kinase A/AKAP79-mediated Switching of the β2-Adrenergic Receptor to Activation of ERK in HEK293B2 Cells

2005 • 208 citations

Regulation of Adenylyl Cyclase by Protein Kinase A

1995 • 202 citations

Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist.

1996 • 188 citations

Voltage-dependent potentiation of L-type Ca2+ channels in skeletal muscle cells requires anchored cAMP-dependent protein kinase.

1994 • 185 citations

Distinct enzyme combinations in AKAP signalling complexes permit functional diversity

2005 • 181 citations

In Vivo Assessment of Local Phosphodiesterase Activity Using Tailored Cyclic Nucleotide–Gated Channels as Camp Sensors

2001 • 163 citations

Negative Feedback Exerted by cAMP-dependent Protein Kinase and cAMP Phosphodiesterase on Subsarcolemmal cAMP Signals in Intact Cardiac Myocytes

2004 • 137 citations

Adenylyl cyclase 6 is selectively regulated by protein kinase A phosphorylation in a region involved in Gα _s stimulation

1997 • 132 citations

Arrestin times for compartmentalised cAMP signalling and phosphodiesterase-4 enzymes

2005 • 131 citations

Imaging kinase–AKAP79–phosphatase scaffold complexes at the plasma membrane in living cells using FRET microscopy

2002 • 124 citations

Role for A Kinase-anchoring Proteins (AKAPS) in Glutamate Receptor Trafficking and Long Term Synaptic Depression

2005 • 121 citations

Gravin-mediated Formation of Signaling Complexes in β2-Adrenergic Receptor Desensitization and Resensitization

2000 • 121 citations

Compartmentalisation of cAMP and Ca2+ signals

2002 • 113 citations

Calcium/Calmodulin Modulation of Olfactory and Rod Cyclic Nucleotide-gated Ion Channels

2003 • 111 citations

Phosphodiesterase 4D Forms a cAMP Diffusion Barrier at the Apical Membrane of the Airway Epithelium

2004 • 111 citations

AKAPs (A-kinase anchoring proteins) and molecules that compose their G-protein-coupled receptor signalling complexes

2004 • 107 citations

Protein kinase A regulates AKAP250 (gravin) scaffold binding to the 2-adrenergic receptor

2003 • 104 citations

Ca2+ stimulation of adenylyl cyclase generates dynamic oscillations in cyclic AMP

2006 • 97 citations

The Scaffold Protein Gravin (cAMP-dependent Protein Kinase-anchoring Protein 250) Binds the β2-Adrenergic Receptor via the Receptor Cytoplasmic Arg-329 to Leu-413 Domain and Provides a Mobile Scaffold during Desensitization

2001 • 96 citations

A Kinase Anchor Protein 75 Targets Regulatory (RII) Subunits of cAMP-dependent Protein Kinase II to the Cortical Actin Cytoskeleton in Non-neuronal Cells

1996 • 79 citations

Simultaneous measurements of intracellular cAMP and L‐type Ca²⁺ current in single frog ventricular myocytes

2001 • 67 citations

Targeting of an A Kinase-anchoring Protein, AKAP79, to an Inwardly Rectifying Potassium Channel, Kir2.1

2001 • 63 citations

Cadherins reach out

2005 • 57 citations

AKAP (A-kinase anchoring protein) domains: beads of structure–function on the necklace of G-protein signalling

2004 • 40 citations

Identification of a region of the C‐terminal domain involved in short‐term desensitization of the prostaglandin EP₄ receptor

1999 • 30 citations