The 15-Deoxy-δ12,14-Prostaglandin J2 Inhibits the Inflammatory Response in Primary Rat Astrocytes via Down-Regulating Multiple Steps in Phosphatidylinositol 3-Kinase-Akt-NF-κB-p300 Pathway Independent of Peroxisome Proliferator-Activated Receptor γ

Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue.

1980 • 3,822 citations

Missing Pieces in the NF-κB Puzzle

2002 • 3,560 citations

The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation

1998 • 3,517 citations

PPAR-γ agonists inhibit production of monocyte inflammatory cytokines

1998 • 2,909 citations

NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

1999 • 2,147 citations

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

1997 • 2,137 citations

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

1995 • 2,036 citations

NF-κB is a target of AKT in anti-apoptotic PDGF signalling

1999 • 1,830 citations

The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

1997 • 1,802 citations

Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase

2000 • 1,337 citations

Immune function of astrocytes

2001 • 1,263 citations

Prostaglandins as modulators of immunity

2002 • 1,167 citations

Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1

1999 • 1,065 citations

PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation

2001 • 1,062 citations

15-Deoxy-Δ ^12,14 -prostaglandin J ₂ inhibits multiple steps in the NF-κB signaling pathway

2000 • 1,014 citations

The Phosphorylation Status of Nuclear NF-ΚB Determines Its Association with CBP/p300 or HDAC-1

2002 • 934 citations

Positive and Negative Regulation of IκB Kinase Activity Through IKKβ Subunit Phosphorylation

1999 • 855 citations

CREB-binding protein/p300 are transcriptional coactivators of p65

1997 • 819 citations

Tlr4: central component of the sole mammalian LPS sensor

2000 • 764 citations

Regulation of activity of the transcription factor GATA-1 by acetylation

1998 • 686 citations

Demyelination: The Role of Reactive Oxygen and Nitrogen Species

1999 • 579 citations

Crystal structure of p50/p65 heterodimer of transcription factor NF-κB bound to DNA

1998 • 578 citations

Different Intracellular Locations for Prostaglandin Endoperoxide H Synthase-1 and −2

1995 • 574 citations

The role of macrophage/microglia and astrocytes in the pathogenesis of three neurologic disorders: HIV-associated dementia, Alzheimer disease, and multiple sclerosis

2002 • 539 citations

Macrophages in Human Atheroma Contain PPARγ

1998 • 536 citations

A new view of prostaglandin E regulation of the immune response

1991 • 535 citations

Differential regulation of IκB kinase α and β by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1

1998 • 531 citations

Peroxisome Proliferator-activated Receptor γ Ligands Are Potent Inhibitors of Angiogenesis in Vitro and in Vivo

1999 • 527 citations

The role of nitric oxide in multiple sclerosis

2002 • 521 citations

Loss-of-Function Mutations in PPARγ Associated with Human Colon Cancer

1999 • 512 citations

Two contact regions between Stat1 and CBP/p300 in interferon γ signaling

1996 • 486 citations

Aminoguanidine, an inhibitor of inducible nitric oxide synthase, ameliorates experimental autoimmune encephalomyelitis in SJL mice.

1994 • 389 citations

Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage

1995 • 378 citations

15-deoxy Δ^ -PGJ2 inhibits multiple steps in the NF-kappaB signaling pathway

2000 • 371 citations

Free radicals and lipid peroxidation mediated injury in burn trauma: the role of antioxidant therapy

2003 • 358 citations

Bridging the Gap: Composition, Regulation, and Physiological Function of the IκB Kinase Complex

1999 • 324 citations

Cyclopentenone prostaglandins suppress activation of microglia: Down-regulation of inducible nitric-oxide synthase by 15-deoxy-Δ ^12,14 -prostaglandin J ₂

1999 • 322 citations

Roles of nitric oxide in brain hypoxia-ischemia

1999 • 309 citations

15-Deoxy-Δ12,14-prostaglandin J2Inhibition of NF-κB-DNA Binding through Covalent Modification of the p50 Subunit

2001 • 297 citations

Specificity of expression and effects of eicosanoid mediators in normal physiology and human diseases ¹

1995 • 275 citations

Inhibition of IκB Kinase and IκB Phosphorylation by 15-Deoxy-Δ^12,14-Prostaglandin J₂ in Activated Murine Macrophages

2000 • 267 citations

A Dominant-negative Peroxisome Proliferator-activated Receptor γ (PPARγ) Mutant Is a Constitutive Repressor and Inhibits PPARγ-mediated Adipogenesis

2000 • 265 citations

5-Aminoimidazole-4-Carboxamide-1-β-4-Ribofuranoside Inhibits Proinflammatory Response in Glial Cells: A Possible Role of AMP-Activated Protein Kinase

2004 • 260 citations

p300 Interacts with the N- and C-terminal Part of PPARγ2 in a Ligand-independent and -dependent Manner, Respectively

1999 • 224 citations

Microglia in neurodegeneration: Molecular aspects

2001 • 212 citations

15d-PGJ2 and Rosiglitazone Suppress Janus Kinase-STAT Inflammatory Signaling through Induction of Suppressor of Cytokine Signaling 1 (SOCS1) and SOCS3 in Glia

2003 • 212 citations

Overexpression of a Constitutively Active Form of Phosphatidylinositol 3-Kinase Is Sufficient to Promote Glut 4 Translocation in Adipocytes

1996 • 158 citations

The α and β Subunits of IκB Kinase (IKK) Mediate TRAF2-Dependent IKK Recruitment to Tumor Necrosis Factor (TNF) Receptor 1 in Response to TNF

2001 • 149 citations

Up-regulation of p300 Binding and p50 Acetylation in Tumor Necrosis Factor-α-induced Cyclooxygenase-2 Promoter Activation

2003 • 141 citations

Inhibition of Phosphatidylinositol 3-Kinase Induces Nitric-oxide Synthase in Lipopolysaccharide- or Cytokine-stimulated C6 Glial Cells

1999 • 120 citations

Tumor Necrosis Factor Alpha Gene Regulation: Enhancement of C/EBPβ-Induced Activation by c-Jun

1998 • 117 citations

Astrogliosis in the Adult and Developing CNS: Is There a Role for Proinflammatory Cytokines?

2001 • 111 citations

Galactosylsphingosine (psychosine) ‐induced expression of cytokine‐mediated inducible nitric oxide synthases via AP‐1 and C/EBP: implications for Krabbe disease

2002 • 98 citations

The C/EBP bZIP Domain Can Mediate Lipopolysaccharide Induction of the Proinflammatory Cytokines Interleukin-6 and Monocyte Chemoattractant Protein-1

2000 • 92 citations

Molecular Cloning and Analysis of the Rat Inducible Nitric Oxide Synthase Gene Promoter in Aortic Smooth Muscle Cells 11The nucleotide sequence data reported in this paper have been submitted to the GenBank with the accession number AF042085.

1998 • 79 citations

Selective Modulation of BV-2 Microglial Activation by Prostaglandin E2

1999 • 77 citations

High Mobility Group-I(Y) Protein Facilitates Nuclear Factor-κB Binding and Transactivation of the Inducible Nitric-oxide Synthase Promoter/Enhancer

1999 • 66 citations

Inducible Nitric Oxide Synthase in the Central Nervous System of Patients with X-Adrenoleukodystrophy

2000 • 63 citations

15-Deoxy-Δ12,14-prostaglandin J2 inhibits IL-1β–induced cyclooxygenase-2 expression in mesangial cells

2002 • 57 citations

Rho a negatively regulates cytokine-mediated inducible nitric oxide synthase expression in brain-derived transformed cell lines: negative regulation of IKKα

2003 • 48 citations

Signal transduction pathways involved in the activation of NF-kappa B, AP-1, and c-fos by Mycoplasma fermentans membrane lipoproteins in macrophages.

1999 • 41 citations