Tumor Necrosis Factor-Induced Mortality Is Reversed with Cyclooxygenase Inhibition

Shock and Tissue Injury Induced by Recombinant Human Cachectin

1986 • 2,587 citations

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

1987 • 2,492 citations

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

1985 • 2,380 citations

Detection of Circulating Tumor Necrosis Factor after Endotoxin Administration

1988 • 1,711 citations

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.

1985 • 1,240 citations

Two distinct monokines, interleukin 1 and tumor necrosis factor, each independently induce biosynthesis and transient expression of the same antigen on the surface of cultured human vascular endothelial cells.

1986 • 748 citations

Prostaglandin E2 regulates macrophage-derived tumor necrosis factor gene expression.

1988 • 670 citations

Participation of tumor necrosis factor in the mediation of gram negative bacterial lipopolysaccharide-induced injury in rabbits.

1988 • 603 citations

Endotoxin and tumor necrosis factor challenges in dogs simulate the cardiovascular profile of human septic shock.

1989 • 567 citations

Cytokine appearance in human endotoxemia and primate bacteremia.

1988 • 528 citations

Tumor necrosis factor and interleukin-1 serum levels during severe sepsis in humans

1989 • 485 citations

Cachectin/tumor necrosis factor induces lethal shock and stress hormone responses in the dog.

1987 • 425 citations

Tumor necrosis factor/cachectin stimulates peritoneal macrophages, polymorphonuclear neutrophils, and vascular endothelial cells to synthesize and release platelet-activating factor.

1987 • 364 citations

Tumor necrosis factor stimulates interleukin-1 and prostaglandin E2 production in resting macrophages

1986 • 344 citations

Interleukin-1 activation of vascular endothelium. Effects on procoagulant activity and leukocyte adhesion.

1985 • 295 citations

The toxic effects of tumor necrosis factor in vivo and their prevention by cyclooxygenase inhibitors.

1987 • 295 citations

Acute in vivo effects of human recombinant tumor necrosis factor.

1987 • 256 citations

The Complex Pattern of Cytokines in Sepsis Association Between Prostaglandins, Cachectin, and Interleukins

1991 • 254 citations

Survival of primates in LD100 septic shock following therapy with antibody to tumor necrosis factor (TNF alpha).

1990 • 236 citations

Tumour cell killing by tumour necrosis factor: inhibition by anaerobic conditions, free-radical scavengers and inhibitors of arachidonate metabolism.

1987 • 206 citations

Production and clearance of tumor necrosis factor in rats exposed to endotoxin and dexamethasone

1987 • 196 citations

Stimulation of lipolysis in cultured fat cells by tumor necrosis factor, interleukin-1, and the interferons is blocked by inhibition of prostaglandin synthesis.

1992 • 184 citations

Role of tumor necrosis factor-alpha in lipopolysaccharide-induced pathologic alterations.

1990 • 174 citations

Recombinant tumor necrosis factor causes activation of human granulocytes

1987 • 164 citations

TNF induces c-fos via a novel pathway requiring conversion of arachidonic acid to a lipoxygenase metabolite.

1991 • 159 citations

Tumor necrosis factor mediates endotoxic effects in mice

1987 • 140 citations

Ibuprofen in canine endotoxin shock.

1982 • 131 citations

Ibuprofen improves survival from endotoxic shock in the rat.

1980 • 129 citations

Tumor necrosis factor stimulates prostaglandin production and cyclic AMP levels in rat cultured mesangial cells

1988 • 105 citations

Toxicity of tumor necrosis factor is synergistic with gamma-interferon and can be reduced with cyclooxygenase inhibitors.

1987 • 90 citations

Tumour‐necrosis‐factor‐mediated cytotoxicity is correlated with phospholipase‐A₂ activity, but not with arachidonic acid release per se

1991 • 80 citations

Effects of acetylsalicylic acid on the canine response to endotoxin.

1967 • 69 citations

The Effects of Tumor Necrosis Factor and Their Selective Inhibition By Ibuprofen

1989 • 69 citations

Role of Tumor Necrosis Factor in Sepsis and Acute Lung injury

1989 • 57 citations

Tumor necrosis factor causes amplification of arachidonic acid metabolism in response to interleukin 1, bradykinin, and other agonists

1989 • 55 citations

Effect of gram-negative endotoxin on levels of serum corticosterone, TNF alpha, circulating blood cells, and the survival of rats.

1990 • 53 citations

Hormonal and metabolic response to recombinant human tumor necrosis factor in rat: in vitro and in vivo

1988 • 51 citations

Relationships between tumour necrosis factor, eicosanoids and platelet‐activating factor as mediators of endotoxin‐induced shock in mice

1990 • 42 citations

Lidocaine or indomethacin improves survival in baboon endotoxin shock

1978 • 41 citations

The role of prostaglandins in sepsis.

1982 • 39 citations

Improved Survival in the Suckling Rat Model of Group B Streptococcal Sepsis After Treatment with Nonsteroidal Anti-inflammatory Drugs

1982 • 29 citations

Tumor Necrosis Factor-α Increases Release of Arachidonate and Prolactin from Rat Anterior Pituitary Cells

1991 • 28 citations

Comparative and interactive in vivo effects of tumor necrosis factor alpha and endotoxin.

1991 • 26 citations

Cardiovascular and pulmonary effects of human recombinant tumor necrosis factor in the conscious rat.

1989 • 16 citations