Platelet activating factor receptor antagonist improves survival and attenuates eicosanoid release in severe endotoxemia.

A Controlled Clinical Trial of High-Dose Methylprednisolone in the Treatment of Severe Sepsis and Septic Shock

1987 • 1,434 citations

Perspectives in platelet-activating factor research.

1987 • 1,383 citations

Effect of High-Dose Glucocorticoid Therapy on Mortality in Patients with Clinical Signs of Systemic Sepsis

1987 • 687 citations

The release of platelet-activating factor from human endothelial cells in culture.

1983 • 436 citations

Platelet-activating factor mediates hemodynamic changes and lung injury in endotoxin-treated rats.

1987 • 364 citations

Platelet activating factor (PAF) involvement in endotoxin-induced hypotension in rats. studies with paf-receptor antagonist kadsurenone

1985 • 298 citations

1-O-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine. A common source of platelet-activating factor and arachidonate in human polymorphonuclear leukocytes.

1984 • 296 citations

INHIBITION OF PHOSPHOLIPASE

1983 • 284 citations

Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) from 1-alkyl-2-acyl-sn-glycero-3-phosphocholine by rat alveolar macrophages. Phospholipase A2 and acetyltransferase activities during phagocytosis and ionophore stimulation.

1983 • 266 citations

Pathobiology of the intravenous infusion of acetyl glyceryl ether phosphorylcholine (AGEPC), a synthetic platelet-activating factor (PAF), in the rabbit.

1980 • 259 citations

Acute circulatory collapse caused by platelet-activating factor (PAF-acether) in dogs

1983 • 243 citations

Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor and a hypotensive lipid) by cholinephosphotransferase in various rat tissues

1981 • 200 citations

Platelet activating factor. Stimulation of the lipoxygenase pathway in polymorphonuclear leukocytes by 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine.

1982 • 194 citations

Selective acylation of lyso platelet activating factor by arachidonate in human neutrophils.

1983 • 148 citations

Biosynthesis of platelet-activating factor (PAF-acether) II. Involvement of phospholipase A2 in the formation of PAF-acether and lyso-PAF-acether from rabbit platelets

1982 • 142 citations

Pathogenesis of hypotension in septic shock

1988 • 124 citations

Ether lipid content and fatty acid distribution in rabbit polymorphonuclear neutrophil phospholipids

1982 • 116 citations

Acetyl glyceryl ether phosphorylcholine-stimulated human platelets cause pulmonary hypertension and edema in isolated rabbit lungs. Role of thromboxane A2.

1983 • 115 citations

Synthesis of PAF-acether and blood volume changes in gram-negative sepsis

1985 • 109 citations

Protective effect of WEB 2086, a novel antagonist of platelet activating factor, in endotoxin shock

1987 • 105 citations

Metabolic fate of platelet-activating factor in neutrophils.

1983 • 97 citations

Ether phospholipids in guinea pig polymorphonuclear leukocytes and macrophages Occurrence of high levels of 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine

1982 • 69 citations

Platelet-activating factor increases lung vascular permeability to protein

1986 • 56 citations

The effects of PAF-acether on the cardiovascular system and their inhibition by a new highly specific PAF-acether receptor antagonist BN 52021

1986 • 50 citations

E. col/ ENDOTOXIN SHOCK IN THE DOG; TREATMENT WITH LIDOCAINE OR INDOMETHACIN

1978 • 45 citations

Pulmonary vascular response to platelet-activating factor in awake sheep and the role of cyclooxygenase metabolites.

1986 • 43 citations

Hypotensive activity of PAF-acether in rats

1982 • 43 citations

Lidocaine or indomethacin improves survival in baboon endotoxin shock

1978 • 41 citations

The alkylacyl and alkenylacyl glycerophospholipids of human platelets

1983 • 39 citations

Metabolism of platelet-activating factor in isolated perfused rat lung.

1987 • 36 citations

Biological properties of the antagonist SRI 63–441 in the PAF and endotoxin models of hypotension in the rat and dog

1987 • 31 citations

Indomethacin improves survival in gram-negative sepsis.

1981 • 30 citations

Interference of the PAF-acether antagonist BN 52021 with endotoxin-induced hypotension in the guinea-pig

1986 • 27 citations

The effects of platelet-activating factor on flow rate and eicosanoid release in the isolated perfused rat gastric vascular bed

1989 • 26 citations

Biphasic effects of platelet-activating factor on coronary blood flow in anesthetized dog

1986 • 23 citations

Evidence of a role for paf-acether in the pathophysiology of the shock state

1986 • 11 citations

Effects of platelet-activating factor on coronary hemodynamics and coronary venous plasma levels of TXB2, 6-keto-PGF1 alpha, and leukotriene C4 immunoreactivity in the intact domestic pig heart.

1985 • 9 citations