Toxicity of tumor necrosis factor is synergistic with gamma-interferon and can be reduced with cyclooxygenase inhibitors.

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

Shock and Tissue Injury Induced by Recombinant Human Cachectin

1986 • 2,587 citations

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

1985 • 2,380 citations

Tumor Necrosis Factor (TNF)

1985 • 1,932 citations

Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in Vitro

1985 • 1,596 citations

Modulation of endothelial cell hemostatic properties by tumor necrosis factor.

1986 • 1,335 citations

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.

1985 • 1,240 citations

Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1.

1986 • 1,079 citations

Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor.

1985 • 1,056 citations

Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors.

1985 • 922 citations

Two distinct monokines, interleukin 1 and tumor necrosis factor, each independently induce biosynthesis and transient expression of the same antigen on the surface of cultured human vascular endothelial cells.

1986 • 748 citations

Molecular Cloning of the Complementary DNA for Human Tumor Necrosis Factor

1985 • 633 citations

An endothelial cell surface factor(s) induced in vitro by lipopolysaccharide, interleukin 1, and tumor necrosis factor-alpha increases neutrophil adherence by a CDw18-dependent mechanism.

1986 • 593 citations

The suppressive influences of human tumor necrosis factors on bone marrow hematopoietic progenitor cells from normal donors and patients with leukemia: synergism of tumor necrosis factor and interferon-gamma.

1986 • 492 citations

Cloning and expression in Escherichia coli of the gene for human tumour necrosis factor

1985 • 464 citations

Human tumor necrosis factor produced by human B-cell lines: synergistic cytotoxic interaction with human interferon.

1983 • 458 citations

Recombinant tumor necrosis factor and immune interferon act singly and in combination to reorganize human vascular endothelial cell monolayers.

1986 • 401 citations

Macrophages as a source of tumoricidal activity (tumor-necrotizing factor)

1980 • 398 citations

The selection and characterization of an invasive variant of the B16 melanoma.

1979 • 376 citations

Induction of the synthesis of tumor necrosis factor receptors by interferon-gamma.

1986 • 328 citations

Antitumor activity of murine tumor necrosis factor (TNF) against transplanted murine tumors and heterotransplanted human tumors in nude mice

1984 • 313 citations

Interferon-gamma enhances expression of cellular receptors for tumor necrosis factor.

1986 • 302 citations

Actions of Tumor Necrosis Factor on Cultured Vascular Endothelial Cells: Morphologic Modulation, Growth Inhibition, and Cytotoxicity

1986 • 300 citations

Recombinant tumor necrosis factor: its effect and its synergism with interferon-γ on a variety of normal and transformed human cell lines

1986 • 279 citations

Experimental model of ischemic bowel necrosis. The role of platelet-activating factor and endotoxin.

1983 • 247 citations

Human tumor xenografts treated with recombinant human tumor necrosis factor alone or in combination with interferons.

1986 • 211 citations

Cell cycle-specific effects of tumor necrosis factor.

1984 • 204 citations

The synergistic anti-proliferative effect of gamma-interferon and human lymphotoxin.

1984 • 193 citations

Gamma interferon and lymphotoxin, released by activated T cells, synergize to inhibit granulocyte/monocyte colony formation.

1986 • 130 citations

Cytotoxic activity of tumor necrosis factor (TNF) on human cancer cells in vitro.

1981 • 113 citations

Activated macrophages release a factor which lyses malignant cells but not normal cells.

1975 • 105 citations

Platelet-activating factor-induced ischemic bowel necrosis. An investigation of secondary mediators in its pathogenesis.

1986 • 95 citations

Generation and characterization of a lipopolysaccharide-induced and serum-derived cytotoxic factor for tumor cells

1980 • 88 citations

The preclinical screening laboratory: evaluation of immunomodulatory and therapeutic properties of biological response modifiers.

1986 • 75 citations

Effects of recombinant human tumor necrosis factor alpha, recombinant human gamma-interferon, and prostaglandin E on colony formation of human hematopoietic progenitor cells stimulated by natural human pluripotent colony-stimulating factor, pluripoietin alpha, and recombinant erythropoietin in serum-free cultures.

1986 • 69 citations

In vitro synergism between interferons and human lymphotoxin: enhancement of lymphotoxin-induced target cell killing.

1983 • 64 citations

Recombinant human tumor necrosis factor — II. Antitumor effect on murine and human tumors transplanted in mice

1986 • 60 citations

Recombinant human tumor necrosis factor — I. Cytotoxic activity in vitro

1986 • 51 citations

Induction and immunological properties of tumor necrosis factor.

1978 • 43 citations

Production of a tumor cytolytic factor(s) by activated human alveolar macrophages and its action.

1984 • 43 citations

Endotoxin-mediated necrosis and regression of established tumours in the mouse

1986 • 38 citations

Role of first stimulating agents in the production of tumor necrosis factor

1984 • 33 citations

Production and characterization of cytostatic protein factors released from human monocytes during exposure to lipopolysaccharide and muramyl dipeptide

1985 • 31 citations

Cytotoxicity Mediated by Soluble Macrophage Product(s)

1975 • 22 citations

Therapeutic Effect of Endogenous Tumor Necrosis Factor on Ascites Meth A Sarcoma

1986 • 13 citations

Effect of Human Recombinant Tumor Necrosis Factor on the Growth of Different Human and Mouse Long-Term Hematopoietic Cell Lines

1986 • 7 citations