Angiogenesis in the Placenta1

The Physiology of Reproduction

1988 • 7,765 citations

Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen

1989 • 4,988 citations

The Biology of Vascular Endothelial Growth Factor

1997 • 4,359 citations

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1996 • 4,143 citations

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1996 • 3,664 citations

Vascular endothelial growth factor (VEGF) and its receptors

1999 • 3,498 citations

Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis

1997 • 3,470 citations

Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis

1996 • 2,844 citations

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1995 • 2,650 citations

Ciba foundation symposium

1964 • 2,217 citations

Vessel Cooption, Regression, and Growth in Tumors Mediated by Angiopoietins and VEGF

1999 • 2,176 citations

Leakage-Resistant Blood Vessels in Mice Transgenically Overexpressing Angiopoietin-1

1999 • 1,372 citations

Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor.

1991 • 999 citations

Regulators of Angiogenesis

1991 • 959 citations

Mesoderm induction in early Xenopus embryos by heparin-binding growth factors

1987 • 953 citations

fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation.

1994 • 784 citations

Murine FGFR-1 is required for early postimplantation growth and axial organization.

1994 • 748 citations

VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells

1998 • 694 citations

Nitric oxide and pregnancy

1997 • 684 citations

Vascularization of the mouse embryo: A study of flk‐1, tek, tie, and vascular endothelial growth factor expression during development

1995 • 546 citations

Comparative morphogenesis of the fetal membranes and accessory uterine structures

1991 • 491 citations

Circulatory Changes during Growth in the Fetal Lamb

1970 • 485 citations

Vascular endothelial growth factor/vascular permeability factor expression in the rat uterus: rapid stimulation by estrogen correlates with estrogen-induced increases in uterine capillary permeability and growth.

1993 • 437 citations

Utero-placental vascular development and placental function

1995 • 419 citations

Direct actions of angiopoietin-1 on human endothelium: evidence for network stabilization, cell survival, and interaction with other angiogenic growth factors.

1999 • 418 citations

Development of Vertebrates

1957 • 379 citations

VEGF-A Induces Expression of eNOS and iNOS in Endothelial Cells via VEGF Receptor-2 (KDR)

1998 • 356 citations

Angiogenesis in female reproductive system

2001 • 338 citations

Epidermal growth factor and basic fibroblast growth factor suppress the spontaneous onset of apoptosis in cultured rat ovarian granulosa cells and follicles by a tyrosine kinase-dependent mechanism.

1992 • 336 citations

Vertebrate fetal membranes

1988 • 330 citations

Angiogenesis in the Corpus Luteum

2000 • 303 citations

Vascular endothelial growth factor, platelet-derived growth factor, and insulin-like growth factor-1 promote rat aortic angiogenesis in vitro.

1994 • 297 citations

Uteroplacental blood flow velocity‐time waveforms in normal and complicated pregnancy

1985 • 284 citations

The Endocrinology of Pregnancy

1997 • 276 citations

Nitric Oxide Mediates Interleukin-1-Induced Gene Expression of Matrix Metalloproteinases and Basic Fibroblast Growth Factor in Cultured Rabbit Articular Chondrocytes

1998 • 275 citations

Uterine artery Doppler flow velocity waveforms in the second trimester for the prediction of preeclampsia and fetal growth retardation.

1994 • 272 citations

Vascular Endothelial Growth Factor Receptor Localization and Activation in Human Trophoblast and Choriocarcinoma Cells1

1994 • 246 citations

Expression of mRNA for vascular endothelial growth factor in human placenta

1993 • 245 citations

Angiopoietin‐1 is an apoptosis survival factor for endothelial cells

1999 • 242 citations

A History of Embryology

1934 • 217 citations

Nitric oxide contributes to estrogen-induced vasodilation of the ovine uterine circulation.

1996 • 215 citations

Role of Nitric Oxide in the Angiogenic Response In Vitro to Basic Fibroblast Growth Factor

1998 • 213 citations

Circannual rhythms in birds: their interaction with circadian rhythms and environmental photoperiod.

1973 • 211 citations

TIE1 and TIE2 Receptor Tyrosine Kinases Inversely Regulate Embryonic Angiogenesis by the Mechanism of Intussusceptive Microvascular Growth

1998 • 209 citations

Suppression of Luteal Angiogenesis in the Primate after Neutralization of Vascular Endothelial Growth Factor¹

2000 • 208 citations

Circulatory Changes in the Reproductive Tissues of Ewes during Pregnancy

1974 • 197 citations

In the human fetus, vascular endothelial growth factor is expressed in epithelial cells and myocytes, but not vascular endothelium: implications for mode of action.

1994 • 196 citations

Angiopoietin-1 and Its Receptor Tie-2 Participate in the Regulation of Capillary-like Tubule Formation and Survival of Endothelial Cells

1999 • 191 citations

Endothelial vasodilator production by uterine and systemic arteries. II. Pregnancy effects on NO synthase expression

1997 • 170 citations

Conceptus attachment in the Ewe: an ultrastructural study

1981 • 165 citations

Implantation and early placentation in domestic ungulates.

1982 • 149 citations

Differential expression of the two VEGF receptors flt and KDR in placenta and vascular endothelial cells

1994 • 144 citations

Maternal Cardiovascular and Other Physiologic Responses to the Endocrinology of Pregnancy

1998 • 143 citations

Angiogenesis in Embryos and Ischemic Diseases

1997 • 139 citations

Transvaginal Doppler ultrasound of the uteroplacental circulation in the early prediction of pre‐eclampsia and intrauterine growth retardation

1997 • 138 citations

Biological Activities of Fibroblast Growth Factors

1991 • 135 citations

Vascular endothelial growth factor (rhVEGF165) stimulates direct angiogenesis in the rabbit cornea.

1994 • 134 citations

Book Review: Handbook of Physiology Section 2

1965 • 128 citations

Localization of vascular endothelial growth factor and its receptor, flt, in human placenta and decidua by immunohistochemistry

1995 • 127 citations

Foundations of Embryology

1964 • 127 citations

The Placenta : Human and Animal

1982 • 126 citations

Endothelial–perivascular cell signaling in vascular development: lessons from knockout mice

1998 • 126 citations

Metabolic and circulatory studies of fetal lamb at midgestation

1986 • 124 citations

Growth and Microvascular Development of the Uterus during Early Pregnancy in Ewes1

1992 • 123 citations

Vascular endothelial growth factor gene expression in ovine placenta and fetal membranes

1995 • 115 citations

Pregnancy-Dependent Changes in Cell Signaling Underlie Changes in Differential Control of Vasodilator Production in Uterine Artery Endothelial Cells¹

2000 • 115 citations

Early pregnancy wastage: relationship between chorionic vascularization and embryonic development

1988 • 115 citations

A HISTOLOGICAL AND HISTOCHEMICAL EXAMINATION OF IMPLANTATION AND EARLY PLACENTOME FORMATION IN SHEEP

1969 • 114 citations

Endothelial vasodilator production by uterine and systemic arteries. III. Ovarian and estrogen effects on NO synthase

1998 • 112 citations

Animal grouping strategies, sources of variation, and economic factors affecting nutrient balance on dairy farms

1999 • 104 citations

Tie-2 and angiopoietin-2 expression at the fetal-maternal interface: a receptor ligand model for vascular remodelling

2000 • 102 citations

Apoptosis occurs in the oligodendroglial lineage, and is prevented by basic fibroblast growth factor

1995 • 99 citations

Uterine vascularity during stimulation and its correlation with implantation in in-vitro fertilization

1995 • 85 citations

Activation of the Mitogen-Activated Protein Kinase Cascade Is Necessary But Not Sufficient for Basic Fibroblast Growth Factor- and Epidermal Growth Factor-Stimulated Expression of Endothelial Nitric Oxide Synthase in Ovine Fetoplacental Artery Endothelial Cells*

1999 • 82 citations

VI. The morphology of the ungulate placenta, particularly the development of that organ in the sheep, and notes upon the placenta of the elephant and hyrax

1906 • 82 citations

Observations upon the form and relations of the maternal and fetal vessels in the placenta of the sheep

1946 • 80 citations

Placental Development in the Sheep and its Relation to Fetal Development

1974 • 79 citations

Effects of chronic environmental heat stress on blood flow and nutrient uptake of the gravid bovine uterus and foetus

1985 • 79 citations

Prenatal development of the sheep.

1945 • 76 citations

Uterine blood flow during early ovine pregnancy

1970 • 72 citations

Time-Course of the Uterine Response to Estradiol-17β in Ovariectomized Ewes: Expression of Angiogenic Factors1

1998 • 72 citations

Effect of NO, vasodilator prostaglandins, and adenosine on skeletal muscle angiogenic growth factor gene expression

1999 • 70 citations

Differential regulation of vascular endothelial growth factor and its receptor fms-like-tyrosine kinase is mediated by nitric oxide in rat renal mesangial cells

1999 • 69 citations

Time-Course of the Uterine Response to Estradiol-17β in Ovariectomized Ewes: Uterine Growth and Microvascular Development1

1998 • 61 citations

Uterine Blood Flow during Early Pregnancy in Ewes: Interaction between the Conceptus and the Ovary Bearing the Corpus Luteum

1984 • 59 citations

Estrogen and progesterone receptors, cell proliferation, and c-fos expression in the ovine uterus during early pregnancy.

1996 • 56 citations

Factors associated with neonatal lamb mortality

1985 • 51 citations

Proliferation and progesterone production of ovine luteal cells from several stages of the estrous cycle: effects of fibroblast growth factors and luteinizing hormone

1995 • 48 citations

Hormonal Regulation of Embryogenesis: The Formation of Mesoderm inXenopus laeuis

1994 • 47 citations

Effects of Fibroblast and Epidermal Growth Factors on Ovarian Cell Proliferationin Vitro. II. Proliferative Response of Luteal Cells to FGF but not EGF

1977 • 47 citations

UTERO-OVARIAN INTERACTIONS DURING EARLY PREGNANCY: ROLE OF CONCEPTUS-INDUCED VASODILATION2

1986 • 47 citations

Transplacental clearance and blood flows of bovine gravid uterus at several stages of gestation

1987 • 46 citations

Angiogenic activity of maternal and fetal placental tissues of ewes throughout gestation

1989 • 37 citations

Secretion of angiogenic activity by placental tissues of cows at several stages of gestation

1988 • 30 citations

Pregnancy Induces an Increase in the Expression of Glyceraldehyde-3-Phosphate Dehydrogenase in Uterine Artery Endothelial Cells

1997 • 27 citations

Angiogenic activity of placental tissues of cows

1987 • 23 citations

Pregnancy induces an increase in the expression of glyceraldehyde-3-phosphate dehydrogenase in uterine artery endothelial cells

1997 • 21 citations

Ciba Foundation Symposium 27 ‐ Size at Birth

1974 • 21 citations

Role of Growth Factors of Uterine and Fetal-Placental Origin During Pregnancy

1998 • 21 citations

Characterization of heparin-binding endothelial mitogen(s) produced by the ovine endometrium during early pregnancy

1998 • 18 citations

Angiogenic activity of ovine placental tissues: immunoneutralization with FGF-2 and VEGF antisera

1995 • 12 citations

Localization and expression of corticotrophin-releasing hormone binding protein in the ovine uterus and placenta

1995 • 1 citations