Characterization of a Protein Kinase B Inhibitor In Vitro and in Insulin-Treated Liver Cells

Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

2005 • 5,837 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

Mechanism of activation of protein kinase B by insulin and IGF-1.

1996 • 2,965 citations

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

1997 • 2,747 citations

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

1997 • 2,245 citations

Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)

2001 • 1,789 citations

Synthesis and Function of 3-Phosphorylated Inositol Lipids

2001 • 1,527 citations

The specificities of protein kinase inhibitors: an update

2003 • 1,345 citations

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation

1998 • 1,101 citations

Akt1/PKBα Is Required for Normal Growth but Dispensable for Maintenance of Glucose Homeostasis in Mice

2001 • 950 citations

Insulin-stimulated Phosphorylation of a Rab GTPase-activating Protein Regulates GLUT4 Translocation

2003 • 937 citations

Akt regulates growth by directly phosphorylating Tsc2

2002 • 932 citations

Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents

2005 • 794 citations

Structure, regulation and function of PKB/AKT—a major therapeutic target

2003 • 695 citations

International Textbook of Diabetes Mellitus

2003 • 666 citations

Phosphorylation of Serine 256 by Protein Kinase B Disrupts Transactivation by FKHR and Mediates Effects of Insulin on Insulin-like Growth Factor-binding Protein-1 Promoter Activity through a Conserved Insulin Response Sequence

1999 • 542 citations

Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors

2004 • 494 citations

The Relationship between the Insulin-binding Capacity of Fat Cells and the Cellular Response to Insulin

1971 • 464 citations

Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors

2005 • 400 citations

Essential role of protein kinase Bγ (PKBγ/Akt3) in postnatal brain development but not in glucose homeostasis

2005 • 399 citations

Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients.

2000 • 374 citations

Identification of a Proline-rich Akt Substrate as a 14-3-3 Binding Partner

2003 • 356 citations

Regulation of Glucose-6-phosphatase Gene Expression by Protein Kinase Bα and the Forkhead Transcription Factor FKHR

2000 • 339 citations

Regulation of Phosphoenolpyruvate Carboxykinase and Insulin-like Growth Factor-binding Protein-1 Gene Expression by Insulin

2000 • 277 citations

Activation of protein kinase B β and γ isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B α

1998 • 275 citations

Pigment epithelium-derived factor downregulates vascular endothelial growth factor (VEGF) expression and inhibits VEGF–VEGF receptor 2 binding in diabetic retinopathy

2006 • 250 citations

Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion

2002 • 240 citations

Inhibition of GSK-3 Selectively Reduces Glucose-6-Phosphatase and Phosphoenolpyruvate Carboxykinase Gene Expression

2001 • 215 citations

Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific Akt/PKB family members

2005 • 176 citations

Functional distinctions of protein kinase B/Akt isoforms defined by their influence on cell migration

2006 • 172 citations

Phosphatidylinositol 3-Kinase, but Not p70/p85 Ribosomal S6 Protein Kinase, Is Required for the Regulation of Phosphoenolpyruvate Carboxykinase (PEPCK) Gene Expression by Insulin

1995 • 148 citations

FKHR Binds the Insulin Response Element in the Insulin-Like Growth Factor Binding Protein-1 Promoter*

1999 • 146 citations

Perspective: The Insulin Signaling System—A Common Link in the Pathogenesis of Type 2 Diabetes

2000 • 129 citations

Activation of Protein Kinase B/Akt Is Sufficient to Repress the Glucocorticoid and cAMP Induction of Phosphoenolpyruvate Carboxykinase Gene

1998 • 127 citations

Differential Regulation of Endogenous Glucose-6-Phosphatase and Phosphoenolpyruvate Carboxykinase Gene Expression by the Forkhead Transcription Factor FKHR in H4IIE-Hepatoma Cells

2001 • 104 citations

Dominant Negative Forms of Akt (Protein Kinase B) and Atypical Protein Kinase Cλ Do Not Prevent Insulin Inhibition of Phosphoenolpyruvate Carboxykinase Gene Transcription

1999 • 101 citations

Central Role for Phosphatidylinositide 3-Kinase in the Repression of Glucose-6-phosphatase Gene Transcription by Insulin

1998 • 94 citations

Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure

2005 • 93 citations

Insulin Regulation of Gene Expression through the Forkhead Transcription Factor Foxo1 (Fkhr) Requires Kinases Distinct from Akt

2001 • 81 citations

The Three Insulin Response Sequences in the Glucose-6-phosphatase Catalytic Subunit Gene Promoter Are Functionally Distinct

2003 • 73 citations

Phosphatidylinositol 3′-Kinase and p70s6k Are Required for Insulin but Not Bisperoxovanadium 1,10-Phenanthroline (bpV(phen)) Inhibition of Insulin-like Growth Factor Binding Protein Gene Expression

1997 • 65 citations

Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element.

2004 • 49 citations

Effect of multiple phosphorylation events on the transcription factors FKHR, FKHRLI and AFX

2002 • 48 citations

Insulin Regulation of Insulin-like Growth Factor-binding Protein-1 Gene Expression Is Dependent on the Mammalian Target of Rapamycin, but Independent of Ribosomal S6 Kinase Activity

2002 • 46 citations

Different mechanisms are used by insulin to repress three genes that contain a homologous thymine‐rich insulin response element

2003 • 18 citations

A temporal switch in the insulin-signalling pathway that regulates hepatic IGF-binding protein-1 gene expression

2006 • 8 citations

Insulin Action Gene Regulation

2007 • 4 citations