Perspective: The Insulin Signaling System—A Common Link in the Pathogenesis of Type 2 Diabetes

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

1997 • 2,174 citations

Disruption of IRS-2 causes type 2 diabetes in mice

1998 • 1,766 citations

Mechanism of free fatty acid-induced insulin resistance in humans.

1996 • 1,507 citations

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

1994 • 1,240 citations

A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance

1998 • 1,173 citations

Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes

1999 • 1,151 citations

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

1994 • 1,076 citations

Phosphoinositide 3-kinases: A conserved family of signal transducers

1997 • 944 citations

Mechanism of activation and function of protein kinase B

1998 • 753 citations

Impaired Glucose Transport as a Cause of Decreased Insulin-Stimulated Muscle Glycogen Synthesis in Type 2 Diabetes

1999 • 666 citations

Early neonatal death in mice homozygous for a null allele of the insulin receptor gene

1996 • 596 citations

Irs-2 coordinates Igf-1 receptor-mediated β-cell development and peripheral insulin signalling

1999 • 526 citations

Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2

2000 • 499 citations

Insulin Signalling and Insulin Actions in the Muscles and Livers of Insulin-Resistant, Insulin Receptor Substrate 1-Deficient Mice

1996 • 289 citations

Altered function of insulin receptor substrate-1–deficient mouse islets and cultured β-cell lines

1999 • 276 citations

4PS/Insulin Receptor Substrate (IRS)-2 Is the Alternative Substrate of the Insulin Receptor in IRS-1-deficient Mice

1995 • 231 citations

The 60 kDa Insulin Receptor Substrate Functions Like an IRS Protein (pp60^IRS3) in Adipose Cells

1997 • 83 citations

Transgenic mice with muscle-specific insulin resistance develop increased adiposity, impaired glucose tolerance, and dyslipidemia.

1996 • 53 citations

Molecular defects of the insulin receptor gene

1995 • 40 citations

Liver-specific insulin receptor knockout mice are severely insulin resistant

1999 • 5 citations