Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors

The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification ¹

1995 • 2,199 citations

The protein kinase B/Akt signalling pathway in human malignancy

2002 • 1,609 citations

Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation.

2001 • 883 citations

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA.

1996 • 785 citations

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma.

1987 • 752 citations

Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC

1998 • 479 citations

Chapter 26. Privileged structures — An update

2000 • 299 citations

Overexpression of Akt/AKT can modulate chemotherapy-induced apoptosis.

2000 • 216 citations

General microwave-assisted protocols for the expedient synthesis of quinoxalines and heterocyclic pyrazines

2004 • 215 citations

Novel PI Analogues Selectively Block Activation of the Pro-survival Serine/Threonine Kinase Akt

2003 • 198 citations

AKT-1, -2, and -3 are expressed in both normal and tumor tissues of the lung, breast, prostate, and colon.

2001 • 144 citations

Targeting Serine / Threonine Protein Kinase B / Akt and Cell-cycle Checkpoint Kinases for Treating Cancer

2002 • 105 citations

Structure-Based Optimization of Novel Azepane Derivatives as PKB Inhibitors

2004 • 100 citations

Role of the AKT kinase in expansion of multiple myeloma clones: effects on cytokine-dependent proliferative and survival responses

2002 • 87 citations

Development of a Custom High-Throughput Preparative Liquid Chromatography/Mass Spectrometer Platform for the Preparative Purification and Analytical Analysis of Compound Libraries

2003 • 83 citations

Emerging targets in the AKT pathway for treatment of androgen-independent prostatic adenocarcinoma

2002 • 65 citations

Use of fluorous silica gel to separate fluorous thiol quenching derivatives in solution-phase parallel synthesis

2002 • 51 citations

Caspase‐8 activation is necessary but not sufficient for tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL)‐mediated apoptosis in the prostatic carcinoma cell line LNCaP

2002 • 41 citations

Fluorous-tethered quenching reagents for solution phase parallel synthesis

2002 • 39 citations