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Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

The Pfam protein families database.

2002 • 14,298 citations

The Sequence of the Human Genome

2001 • 13,500 citations

Initial sequencing and comparative analysis of the mouse genome

2002 • 6,971 citations

Prediction of complete gene structures in human genomic DNA

1997 • 4,041 citations

Model-based analysis of oligonucleotide arrays: Expression index computation and outlier detection

2000 • 3,126 citations

The Pfam protein families database

2003 • 2,952 citations

The Sequence of the Human Genome

2015 • 1,654 citations

The Ensembl genome database project

2002 • 1,606 citations

Genetics of gene expression surveyed in maize, mouse and man

2003 • 1,518 citations

The DNA sequence of human chromosome 21

2000 • 1,406 citations

Genome-Wide Survey of Human Alternative Pre-mRNA Splicing with Exon Junction Microarrays

2003 • 1,406 citations

Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer

2001 • 1,297 citations

The DNA sequence of human chromosome 22

1999 • 1,167 citations

Ab initio Gene Finding in Drosophila Genomic DNA

2000 • 1,095 citations

Unbiased Mapping of Transcription Factor Binding Sites along Human Chromosomes 21 and 22 Points to Widespread Regulation of Noncoding RNAs

2004 • 1,079 citations

Empirical Analysis of Transcriptional Activity in the Arabidopsis Genome

2003 • 906 citations

RefSeq and LocusLink: NCBI gene-centered resources

2001 • 899 citations

Complete sequencing and characterization of 21,243 full-length human cDNAs

2003 • 888 citations

Signaling and Circuitry of Multiple MAPK Pathways Revealed by a Matrix of Global Gene Expression Profiles

2000 • 867 citations

Large-Scale Transcriptional Activity in Chromosomes 21 and 22

2002 • 839 citations

Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.

1995 • 804 citations

A Computer Program for Aligning a cDNA Sequence with a Genomic DNA Sequence

1998 • 745 citations

The InterPro Database, 2003 brings increased coverage and new features

2003 • 698 citations

Using the transcriptome to annotate the genome

2002 • 637 citations

An Expanding Universe of Noncoding RNAs

2002 • 631 citations

Novel RNAs Identified From an In-Depth Analysis of the Transcriptome of Human Chromosomes 21 and 22

2004 • 529 citations

AVID: A Global Alignment Program

2002 • 496 citations

Experimental annotation of the human genome using microarray technology

2001 • 446 citations

<tt>rVista</tt>for Comparative Sequence-Based Discovery of Functional Transcription Factor Binding Sites

2002 • 442 citations

The DNA sequence and comparative analysis of human chromosome 20

2001 • 367 citations

Analysis of expressed sequence tags indicates 35,000 human genes

2000 • 367 citations

Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors

2002 • 300 citations

The transcriptional activity of human Chromosome 22

2003 • 293 citations

Gene Index analysis of the human genome estimates approximately 120,000 genes

2000 • 282 citations

The Mammalian Gene Collection

1999 • 277 citations

Evaluation of Gene-Finding Programs on Mammalian Sequences

2001 • 273 citations

Computational methods for the identification of genes in vertebrate genomic sequences

1997 • 264 citations

d2_cluster: A Validated Method for Clustering EST and Full-Length cDNA Sequences

1999 • 202 citations

Transcriptome analysis of Escherichia coli using high-density oligonucleotide probe arrays

2002 • 191 citations

Spatial flexibility in ternary complexes between SRF and its accessory proteins.

1992 • 175 citations

The contribution of 700,000 ORF sequence tags to the definition of the human transcriptome

2001 • 142 citations

A draft annotation and overview of the human genome

2001 • 106 citations

Automated Gene Identification in Large-Scale Genomic Sequences¹

1997 • 99 citations

Optimization of oligonucleotide arrays and RNA amplification protocols for analysis of transcript structure and alternative splicing

2003 • 85 citations

Reevaluating Human Gene Annotation: A Second-Generation Analysis of Chromosome 22

2002 • 81 citations

5' flanking and first intron sequences of the human β-actin gene required for efficient promoter activity

1989 • 73 citations

Identification of the human beta-actin enhancer and its binding factor.

1988 • 67 citations