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Two Key Proteins of the Vitamin D Endocrine System Come Into Crystal Clear Focus: Comparison of the X-ray Structures of the Nuclear Receptor for 1α,25(OH)2 Vitamin D3, the Plasma Vitamin D Binding Protein, and Their Ligands

Data up to Jan 2025

Published2003
Citations21
References55

Total Citations Per Year

Abstract

References (55)

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

Atomic structure and chemistry of human serum albumin

1992 • 3,693 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

Molecular basis of agonism and antagonism in the oestrogen receptor

1997 • 3,285 citations

Crystal structure of human serum albumin at 2.5 Å resolution

1999 • 1,658 citations

Combinatorial Control of Gene Expression by Nuclear Receptors and Coregulators

2002 • 1,449 citations

Structure-Function Relationships in the Vitamin D Endocrine System*

1995 • 1,182 citations

Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α

1995 • 1,179 citations

Crystal structure of the RAR-γ ligand-binding domain bound to all-trans retinoic acid

1995 • 1,085 citations

The human estrogen receptor has two independent nonacidic transcriptional activation functions

1989 • 1,066 citations

Nuclear receptors enhance our understanding of transcription regulation

1988 • 1,062 citations

The Role of the Vitamin D Endocrine System in Health and Disease

1989 • 1,041 citations

A structural role for hormone in the thyroid hormone receptor

1995 • 938 citations

The Crystal Structure of the Nuclear Receptor for Vitamin D Bound to Its Natural Ligand

2000 • 802 citations

Crystal Structure Analysis of Warfarin Binding to Human Serum Albumin

2001 • 779 citations

The chicken oestrogen receptor sequence: homology with v-erbA and the human oestrogen and glucocorticoid receptors.

1986 • 733 citations

Structural determinants of nuclear receptor assembly on DNA direct repeats

1995 • 561 citations

Nuclear receptor ligand-binding domains: three-dimensional structures, molecular interactions and pharmacological implications

2000 • 459 citations

Group-specific component (Gc) proteins bind vitamin D and 25-hydroxyvitamin D.

1975 • 372 citations

20-EPI-vitamin D3 analogues: A novel class of potent regulators of cell growth and immune responses

1991 • 320 citations

Nuclear-Receptor Ligands and Ligand-Binding Domains

1999 • 314 citations

Parathyroid hormone suppression by intravenous 1,25-dihydroxyvitamin D. A role for increased sensitivity to calcium.

1989 • 263 citations

Crystal structures of the vitamin D receptor complexed to superagonist 20-epi ligands

2001 • 223 citations

25-Hydroxyvitamin D transport in human plasma. Isolation and partial characterization of calcifidiol-binding protein.

1976 • 218 citations

Distinct Conformational Changes Induced by 20-epi Analogues of 1α,25-Dihydroxyvitamin D3 Are Associated with Enhanced Activation of the Vitamin D Receptor

1995 • 201 citations

Serum vitamin D-binding protein is a third member of the albumin and alpha fetoprotein gene family.

1985 • 192 citations

Angiopathic consequences of saturating the plasma scavenger system for actin.

1990 • 188 citations

The Measurement of the Vitamin D-Binding Protein in Human Serum

1977 • 185 citations

Crystal structure of human sex hormone-binding globulin: steroid transport by a laminin G-like domain

2000 • 168 citations

Plasma vitamin D-binding protein (Gc-globulin): Multiple tasks

1995 • 155 citations

Crystal structures of the vitamin D-binding protein and its complex with actin: Structural basis of the actin-scavenger system

2002 • 153 citations

A structural basis for the unique binding features of the human vitamin D-binding protein

2002 • 145 citations

Estradiol causes the rapid accumulation of cAMP in human prostate.

1994 • 136 citations

Differential Interaction of α,25-Dihydroxyvitamin D3 Analogues and Their 20-epi Homologues with the Vitamin D Receptor

1997 • 103 citations

The Advantage of Alfacalcidol Over Vitamin D in the Treatment of Osteoporosis

1999 • 82 citations

Characterization of a Novel Analogue of 1α,25(OH)2-Vitamin D3 with Two Side Chains: Interaction with Its Nuclear Receptor and Cellular Actions

2000 • 81 citations

Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARγ

2000 • 81 citations

Molecular tools for study of genomic and rapid signal transduction responses initiated by 1α,25(OH)2-vitamin D3

2002 • 80 citations

Vitamin D in Solution: Conformations of Vitamin D 3 , 1α,25-Dihydroxyvitamin D 3 , and Dihydrotachysterol 3

1974 • 79 citations

Minireview: Genomics Versus Orphan Nuclear Receptors—A Half-Time Report

2002 • 76 citations

Receptors for androgen-binding proteins: Internalization and intracellular signalling

1995 • 73 citations

Binding of steroids to uteroglobin

1976 • 70 citations

Transport of vitamin D: Significance of free and total concentrations of the vitamin D metabolites

1981 • 69 citations

Vitamin D: Structure‐function analyses and the design of analogs

1992 • 61 citations

Elastase Controls the Binding of the Vitamin D-Binding Protein (Gc-Globulin) to Neutrophils: A Potential Role in the Regulation of C5a Co-Chemotactic Activity

2001 • 53 citations

Effect of C2O stereochemistry on the conformational profile of the side chains of vitamin D analogs.

1993 • 52 citations

Polyunsaturated fatty acids decrease the apparent affinity of vitamin D metabolites for human vitamin D-binding protein

1992 • 51 citations

Physical and Meiotic Mapping of the Region of Human Chromosome 4q11–q13 Encompassing the Vitamin D Binding Protein DBP/Gc-Globulin and Albumin Multigene Cluster

1999 • 50 citations

Initial Characterization of the Vitamin D Binding Protein (Gc-Globulin) Binding Site on the Neutrophil Plasma Membrane: Evidence for a Chondroitin Sulfate Proteoglycan

1999 • 50 citations

Vitamin D binding protein.

1997 • 43 citations

Topical vitamin D3(tacalcitol) for steroid-resistant prurigo

1996 • 40 citations

Origin of structural domains of the serum-albumin gene family and a predicted structure of the gene for vitamin D-binding protein.

1987 • 36 citations

Biochemical and preliminary crystallographic characterization of the vitamin D sterol- and actin-binding by human vitamin D-binding protein

2002 • 33 citations

Immunomodulatory effects of vitamin D analog KH1060 on an experimental skin transplantation model

1999 • 29 citations

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