Integration of global SNP-based mapping and expression arrays reveals key regions, mechanisms, and genes important in the pathogenesis of multiple myeloma

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB

2003 • 946 citations

A Robust Algorithm for Copy Number Detection Using High-Density Oligonucleotide Single Nucleotide Polymorphism Genotyping Arrays

2005 • 651 citations

Superiority of Tandem Autologous Transplantation Over Standard Therapy for Previously Untreated Multiple Myeloma

1997 • 576 citations

Chromosome translocations in multiple myeloma

2001 • 481 citations

WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer.

2000 • 419 citations

Hypodiploidy is a major prognostic factor in multiple myeloma

2001 • 394 citations

dChipSNP: significance curve and clustering of SNP-array-based loss-of-heterozygosity data

2004 • 383 citations

Genomic abnormalities in monoclonal gammopathy of undetermined significance

2002 • 351 citations

Deletion of 13q14 remains an independent adverse prognostic variable in multiple myeloma despite its frequent detection by interphase fluorescence in situ hybridization

2000 • 328 citations

Chromosome 13 abnormalities identified by FISH analysis and serum β2-microglobulin produce a powerful myeloma staging system for patients receiving high-dose therapy

2001 • 314 citations

Presence of a p53 Gene Deletion in Patients With Multiple Myeloma Predicts for Short Survival After Conventional-Dose Chemotherapy

1998 • 311 citations

The recurrent IgH translocations are highly associated with nonhyperdiploid variant multiple myeloma

2003 • 290 citations

Genome-Wide Single Nucleotide Polymorphism Analysis Reveals Frequent Partial Uniparental Disomy Due to Somatic Recombination in Acute Myeloid Leukemias

2005 • 276 citations

Frequent loss of heterozygosity for loci on chromosome 8p in hepatocellular carcinoma, colorectal cancer, and lung cancer.

1992 • 269 citations

WWOX, the FRA16D gene, behaves as a suppressor of tumor growth.

2001 • 267 citations

Association between Acquired Uniparental Disomy and Homozygous Gene Mutation in Acute Myeloid Leukemias

2005 • 245 citations

Improved cytogenetics in multiple myeloma: a study of 151 patients including 117 patients at diagnosis

1995 • 238 citations

Insights into the multistep transformation of MGUS to myeloma using microarray expression analysis

2003 • 238 citations

Chromosome abnormalities clustering and its implications for pathogenesis and prognosis in myeloma

2003 • 229 citations

Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: analysis of the Eastern Cooperative Oncology Group Phase III Trial

1996 • 229 citations

14q32 translocations and monosomy 13 observed in monoclonal gammopathy of undetermined significance delineate a multistep process for the oncogenesis of multiple myeloma. Intergroupe Francophone du Myélome.

1999 • 206 citations

Multiple myeloma: high incidence of chromosomal aneuploidy as detected by interphase fluorescence in situ hybridization.

1995 • 206 citations

High incidence of N and K-Ras activating mutations in multiple myeloma and primary plasma cell leukemia at diagnosis

2001 • 190 citations

Fragile genes as biomarkers: epigenetic control of WWOX and FHIT in lung, breast and bladder cancer

2005 • 186 citations

High incidence of chromosome 13 deletion in multiple myeloma detected by multiprobe interphase FISH

2000 • 179 citations

Gene Expression Profiling of Localized Esophageal Carcinomas: Association With Pathologic Response to Preoperative Chemoradiation

2005 • 168 citations

MULTIPLE MYELOMA: ALMOST ALL PATIENTS ARE CYTOGENETICALLY ABNORMAL

1996 • 161 citations

Amplification and overexpression of CKS1B at chromosome band 1q21 is associated with reduced levels of p27 Kip1 and an aggressive clinical course in multiple myeloma

2005 • 157 citations

Genomewide Single Nucleotide Polymorphism Microarray Mapping in Basal Cell Carcinomas Unveils Uniparental Disomy as a Key Somatic Event

2005 • 157 citations

Characterization of Nonrandom Chromosomal Gains and Losses in Multiple Myeloma by Comparative Genomic Hybridization

1998 • 153 citations

Characterization of 8p21.3 chromosomal deletions in B-cell lymphoma: TRAIL-R1 and TRAIL-R2 as candidate dosage-dependent tumor suppressor genes

2005 • 151 citations

Deletions below 10 megabasepairs are detected in comparative genomic hybridization by standard reference intervals

1999 • 145 citations

Deletions of chromosome 13 in multiple myeloma identified by interphase FISH usually denote large deletions of the q arm or monosomy

2001 • 139 citations

Complex and segmental uniparental disomy (UPD): review and lessons from rare chromosomal complements

2001 • 131 citations

Mitotic recombination map of 13cen–13q14 derived from an investigation of loss of heterozygosity in retinoblastomas

1999 • 116 citations

Ploidy, as detected by fluorescence in situ hybridization, defines different subgroups in multiple myeloma

2004 • 114 citations

WW domain containing oxidoreductase gene expression is altered in non-small cell lung cancer.

2003 • 113 citations

Chromosomal imbalances are associated with a high risk of progression in early invasive (pT1) urinary bladder cancer.

1999 • 110 citations

Homozygous deletions at 8p22 and 8p21 in prostate cancer implicate these regions as the sites for candidate tumor suppressor genes.

1995 • 107 citations

Candidate tumor-suppressor genes on chromosome arm 8p in early-onset and high-grade breast cancers

2004 • 105 citations

Prognostic and biologic significance of chromosomal imbalances assessed by comparative genomic hybridization in multiple myeloma

2004 • 104 citations

Chromosome 13 abnormalities in multiple myeloma are mostly monosomy 13

2000 • 103 citations

Chromosome 8p deletions are associated with invasive tumor growth in urinary bladder cancer.

1997 • 100 citations

Overexpression of PDZK1 within the 1q12-q22 Amplicon Is Likely To Be Associated with Drug-Resistance Phenotype in Multiple Myeloma

2004 • 94 citations

Delineation of distinct subgroups of multiple myeloma and a model for clonal evolution based on interphase cytogenetics

2005 • 93 citations

Methylation is an inactivating mechanism of the p16 gene in multiple myeloma associated with high plasma cell proliferation and short survival

2002 • 81 citations

Age has a profound effect on the incidence and significance of chromosome abnormalities in myeloma

2005 • 80 citations

Mutation analysis of the 8p candidate tumour suppressor genes DBC2 (RHOBTB2) and LZTS1 in bladder cancer

2004 • 76 citations

A pooled analysis of karyotypic patterns, breakpoints and imbalances in 783 cytogenetically abnormal multiple myelomas reveals frequently involved chromosome segments as well as significant age‐ and sex‐related differences

2003 • 76 citations

Deletions of chromosome 13q in monoclonal gammopathy of undetermined significance

2000 • 73 citations

Acquired Homozygosity (Isodisomy) of Chromosome 3 in Uveal Melanoma

1998 • 71 citations

Localization of a tumor suppressor gene associated with the progression of human breast carcinoma within a 1-cm interval of 8p22-p23.1

1999 • 69 citations

Loss of Heterozygosity Associated with Uniparental Disomy in Breast Carcinoma

2002 • 61 citations

Frequent multiplication of the long arm of chromosome 8 in hepatocellular carcinoma.

1993 • 60 citations

De novo methylation of tumor suppressor gene p16/INK4a is a frequent finding in multiple myeloma patients at diagnosis

2000 • 59 citations

Characterization of {gamma}-aminobutyric acid type A receptor-associated protein, a novel tumor suppressor, showing reduced expression in breast cancer.

2005 • 56 citations

Analysis of DLC-1 expression in human breast cancer

2003 • 54 citations

Characterization of γ-Aminobutyric Acid Type A Receptor–Associated Protein, a Novel Tumor Suppressor, Showing Reduced Expression in Breast Cancer

2005 • 50 citations

Hypermethylation of p16INK4A gene promoter during the progression of plasma cell dyscrasia

2001 • 50 citations

Value of comparative genomic hybridization and fluorescence in situ hybridization for molecular diagnostics in multiple myeloma

2003 • 46 citations

HTPAP gene on chromosome 8p is a candidate metastasis suppressor for human hepatocellular carcinoma

2005 • 35 citations

Analysis of p73 and p53 gene deletions in multiple myeloma

1999 • 35 citations

Enforced Expression of Superoxide Dismutase 2/Manganese Superoxide Dismutase Disrupts Autocrine Interleukin-6 Stimulation in Human Multiple Myeloma Cells and Enhances Dexamethasone-Induced Apoptosis

2005 • 32 citations

Frequent multiplication of chromosomal region 8q24.1 associated with aggressive histologic types of breast cancers

1999 • 23 citations

Using Genomics to Identify High-Risk Myeloma after Autologous Stem Cell Transplantation

2006 • 23 citations

Hemizygous Deletions of Chromosome Band 16q24 in Wilms Tumor

1999 • 21 citations

Comprehensive Genome-Wide Profile of Regional Gains and Losses in Multiple Myeloma Using Array-CGH: The 1q21 Amplification and Potential Role of the BCL-9 Gene in Multiple Myeloma Pathogenesis.

2004 • 6 citations

Interphase FISH-Defined Amplification of Chromosome 1q21 (AMP1q21) Identify High-Risk Subsets among Patients with Multiple Myeloma (MM) Lacking Metaphase Cytogenetic Abnormalities (CA).

2005 • 4 citations

Low Level Amplification (Duplication) of 1q21 in Myeloma and Prognosis; the Role of CKS1B.

2005 • 2 citations