Hypermethylation of p16INK4A gene promoter during the progression of plasma cell dyscrasia

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

1996 • 5,667 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

A clinical staging system for multiple myeloma correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival

1975 • 3,051 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

1997 • 1,960 citations

Role for DNA methylation in genomic imprinting

1994 • 1,695 citations

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

1995 • 1,500 citations

The essentials of DNA methylation

1992 • 960 citations

Aberrant methylation of p16 ^INK4a is an early event in lung cancer and a potential biomarker for early diagnosis

1998 • 953 citations

Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients.

1999 • 920 citations

Multiple Myeloma: Increasing Evidence for a Multistep Transformation Process

1998 • 761 citations

Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B.

1996 • 585 citations

Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia–lymphoma cells

1998 • 436 citations

Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies.

1997 • 420 citations

Genomic Sequencing and Methylation Analysis by Ligation Mediated PCR

1989 • 408 citations

Role of the cyclin-dependent kinase inhibitors in the development of cancer

1995 • 404 citations

Methylation of the p15INK4b Gene in Myelodysplastic Syndromes Is Frequent and Acquired During Disease Progression

1998 • 352 citations

DNA Methylation

1999 • 341 citations

Role of the cyclin-dependent kinase inhibitors in the development of cancer

1995 • 321 citations

Detection of mRNA for the tax1/rex1 gene of human T-cell leukemia virus type I in fresh peripheral blood mononuclear cells of adult T-cell leukemia patients and viral carriers by using the polymerase chain reaction.

1989 • 289 citations

Mutations of the p53 Gene as a Prognostic Factor in Aggressive B-Cell Lymphoma

1997 • 281 citations

p53 in hematologic malignancies

1994 • 269 citations

Hypermethylation of the p15INK4B Gene in Myelodysplastic Syndromes

1997 • 260 citations

Staging and kinetics of multiple myeloma.

1986 • 215 citations

p53 in hematologic malignancies

1994 • 206 citations

Aberrant p15 promoter methylation in adult and childhood acute leukemias of nearly all morphologic subtypes: potential prognostic implications

2000 • 202 citations

Frequent Hypermethylation of p16 and p15 Genes in Multiple Myeloma

1997 • 195 citations

The MDM2 oncogene overexpression in chronic lymphocytic leukemia and low-grade lymphoma of B-cell origin

1994 • 164 citations

Cdkn2a, the cyclin-dependent kinase inhibitor encoding p16^INK4aand p19^ARF, is a candidate for the plasmacytoma susceptibility locus,Pctr1

1998 • 148 citations

Homozygous Deletions at Chromosome 9p21 Involving p16 and p15 Are Associated With Histologic Progression in Follicle Center Lymphoma

1998 • 144 citations

Deletions of p15 and/or p16 genes as a poor-prognosis factor in adult T-cell leukemia.

1997 • 121 citations

Extensive intra- and interindividual heterogeneity of p15INK4B methylation in acute myeloid leukemia.

1999 • 121 citations

Acquisition of p16INK4Aandp15INK4BGene Abnormalities Between Initial Diagnosis and Relapse in Children With Acute Lymphoblastic Leukemia

1999 • 80 citations

Analysis of the p16^INK4A, p15^INK4B and p18^INK4C genes in multiple myeloma

1997 • 64 citations

De novo methylation of tumor suppressor gene p16/INK4a is a frequent finding in multiple myeloma patients at diagnosis

2000 • 59 citations

Methylation of the p16^INK4A gene in multiple myeloma

1998 • 53 citations

Mutational analysis of the CDKN2 (MTS1/p16ink4A) gene in primary B-cell lymphomas

1995 • 51 citations

Evidence for nonclonal hematopoietic progenitor cell populations in bone marrow of patients with myelodysplastic syndromes

1994 • 48 citations

Transcriptional silencing of the p16 gene in human myeloma-derived cell lines by hypermethylation.

1998 • 42 citations

Remission induction of acute promyelocytic leukemia by all-trans-retinoic acid: molecular evidence of restoration of normal hematopoiesis after differentiation and subsequent extinction of leukemic clone.

1992 • 41 citations

p16 gene analysis in multiple myeloma (MM).

1996 • 4 citations