Catalytic Activity of Three Variants (Ile, Leu, and Thr) at Amino Acid Residue 359 in Human CYP2C9 Gene and Simultaneous Detection Using Single-Strand Conformation Polymorphism Analysis

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

1994 • 2,716 citations

Hepatic Triphosphopyridine Nucleotide-Cytochrome c Reductase: Isolation, Characterization, and Kinetic Studies

1962 • 1,431 citations

Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences.

1992 • 1,168 citations

PCR-SSCP: a simple and sensitive method for detection of mutations in the genomic DNA.

1991 • 780 citations

The role of the CFP2C9-Leu 359 allelic variant in the tolbutamide polymorphism

1996 • 584 citations

Biochemistry and molecular biology of the human CYP2C subfamily

1994 • 534 citations

High-frequency transformation method and library transducing vectors for cloning mammalian cDNAs bytrans-complementation ofSchizosaccharomyces pombe

1990 • 434 citations

Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue

1989 • 382 citations

Genetic analysis of the human cytochrome P450 CYP2C9 locus

1996 • 300 citations

The R144C change in the CYP2C9*2 allele alters interaction of the cytochrome P450 with NADPH:cytochrome P450 oxidoreductase

1997 • 269 citations

Allelic Variants of Human Cytochrome P450 2C9: Baculovirus-Mediated Expression, Purification, Structural Characterization, Substrate Stereoselectivity, and Prochiral Selectivity of the Wild-Type and I359L Mutant Forms

1996 • 256 citations

Genetic Polymorphism of Cytochrome P450s, CYP2C19, and CYP2C9 in a Japanese Population

1998 • 208 citations

Detection of CYP2C9 polymorphism based on the polymerase chain reaction in Chinese

1995 • 195 citations

Pharmacogenetic Phenotyping and Genotyping

1994 • 189 citations

The Effects of Genetic Polymorphisms of CYP2C9 and CYP2C 19 on Phenytoin Metabolism in Japanese Adult Patients with Epilepsy: Studies in Stereoselective Hydroxylation and Population Pharmacokinetics

1998 • 178 citations

The primary structure of the alcohol dehydrogenase gene from the fission yeast Schizosaccharomyces pombe.

1983 • 175 citations

Pharmacokinetics of chlorpheniramine, phenytoin, glipizide and nifedipine in an individual homozygous for the CYP2C9*3 allele

1999 • 169 citations

Comparative Studies on the Catalytic Roles of Cytochrome P450 2C9 and Its Cys- and Leu-Variants in the Oxidation of Warfarin, Flurbiprofen, and Diclofenac by Human Liver Microsomes

1998 • 169 citations

Comparisons between in-vitro and in-vivo metabolism of (S)-warfarin: catalytic activities of cDNA-expressed CYP2C9, its Leu359 variant and their mixture versus unbound clearance in patients with the corresponding CYP2C9 genotypes

1998 • 162 citations

Polymorphism of the cytochrome P450 (CYP) 2C9 gene in Japanese epileptic patients: genetic analysis of the CYP2C9 locus

2000 • 130 citations

Allelic and functional variability of cytochrome P4502C9

1997 • 86 citations

A molecular model for the enzyme cytochrome P45017α, a major target for the chemotherapy of prostatic cancer

1990 • 85 citations

An efficient strategy for detection of known and new mutations of the CYP2D6 gene using single strand conformation polymorphism analysis

1995 • 72 citations

Human hepatic cytochrome P450 2C9 catalyzes the rate-limiting pathway of torsemide metabolism.

1995 • 66 citations

Nucleotide Sequence of a Human Liver Cytochrome P-450 Related to the Rat Male Specific Form1

1987 • 53 citations

Identification of Residues 286 and 289 as Critical for Conferring Substrate Specificity of Human CYP2C9 for Diclofenac and Ibuprofen

1998 • 50 citations

High–Level Expression of Human Lipocortin I in the Fission Yeast Schizosaccharomyces pombe Using a Novel Expression Vector

1994 • 50 citations

The role of cytochrome P450 lysine residues in the interaction between cytochrome P450IA1 and NADPH-cytochrome P450 reductase

1992 • 46 citations

A mutation in CYP2C9 is responsible for decreased metabolism of losartan.

1996 • 25 citations

Population pharmacokinetics of phenytoin from routine clinical data in Japan: An update.

1990 • 23 citations

Characterization of Monkey Cytochrome P450, P450 CMLd, Responsible for S-Mephenytoin 4′-Hydroxylation in Hepatic Microsomes of Cynomolgus Monkeys

1994 • 13 citations

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