A novel mutant variant of the CYP2D6 gene (CYP2D617) common in a black African population: association with diminished debrisoquine hydroxylase activity

Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification

1990 • 451 citations

The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.

1989 • 407 citations

Nomenclature for human CYP2D6 alleles

1996 • 406 citations

Frequent distribution of ultrarapid metabolizers of debrisoquine in an ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles.

1996 • 373 citations

The genetic polymorphism of debrisoquine/sparteine metabolism — Clinical aspects

1990 • 367 citations

Prevalence of CYP2D6 gene duplication and its repercussion on the oxidative phenotype in a white population*

1995 • 187 citations

Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype

1991 • 147 citations

Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism

1993 • 146 citations

A preliminary 3D model for cytochrome P450 2D6 constructed by homology model building

1993 • 64 citations

Site-directed mutagenesis of putative substrate recognition sites in cytochrome P450 2B11: importance of amino acid residues 114, 290, and 363 for substrate specificity.

1994 • 47 citations

Differences in Drug Metabolism Polymorphism Between Orientals and Caucasians

1990 • 39 citations

Evidence for a dissociation in the control of sparteine, debrisoquine and metoprolol metabolism in Nigerians

1992 • 36 citations

Pharmacokinetic and other related factors affecting psychotropic responses in Asians.

1991 • 32 citations