CYP2C9 Ile359 and Leu359 variants: enzyme kinetic study with seven substrates

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

Hepatic Triphosphopyridine Nucleotide-Cytochrome c Reductase: Isolation, Characterization, and Kinetic Studies

1962 • 1,431 citations

Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences.

1992 • 1,168 citations

Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions

1992 • 605 citations

The role of the CFP2C9-Leu 359 allelic variant in the tolbutamide polymorphism

1996 • 584 citations

Biochemistry and molecular biology of the human CYP2C subfamily

1994 • 534 citations

High-frequency transformation method and library transducing vectors for cloning mammalian cDNAs bytrans-complementation ofSchizosaccharomyces pombe

1990 • 434 citations

Genetic association between sensitivity to warfarin and expression of CYP2C9*3

1997 • 309 citations

Genetic analysis of the human cytochrome P450 CYP2C9 locus

1996 • 300 citations

Cytochrome P450TB (CYP2C): A major monooxygenase catalyzing diclofenac 4′-hydroxylation in human liver

1993 • 258 citations

Allelic Variants of Human Cytochrome P450 2C9: Baculovirus-Mediated Expression, Purification, Structural Characterization, Substrate Stereoselectivity, and Prochiral Selectivity of the Wild-Type and I359L Mutant Forms

1996 • 256 citations

Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily.

1990 • 218 citations

Tolbutamide and phenytoin hydroxylations by cDNA-expressed human liver cytochrome P4502C9

1991 • 208 citations

Roles of cytochrome P4502C9 and cytochrome P4502C19 in the stereoselective metabolism of phenytoin to its major metabolite.

1996 • 197 citations

Detection of CYP2C9 polymorphism based on the polymerase chain reaction in Chinese

1995 • 195 citations

Genetic analysis of CYP2C9 polymorphism in a Japanese population

1997 • 190 citations

Metabolism of warfarin enantiomers in Japanese patients with heart disease having different CYP2C9 and CYP2C19 genotypes*

1998 • 183 citations

The primary structure of the alcohol dehydrogenase gene from the fission yeast Schizosaccharomyces pombe.

1983 • 175 citations

Pharmacokinetics of chlorpheniramine, phenytoin, glipizide and nifedipine in an individual homozygous for the CYP2C9*3 allele

1999 • 169 citations

Genetic polymorphism of the CYP2C subfamily and its effect on the pharmacokinetics of phenytoin in Japanese patients with epilepsy*

1997 • 156 citations

Correlation of human cytochrome P4502C substrate specificities with primary structure: warfarin as a probe.

1993 • 139 citations

Site-directed mutation studies of human liver cytochrome P-450 isoenzymes in the CYP2C subfamily

1993 • 132 citations

Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359allele as low-Kmcatalysts of cyclophosphamide and ifosfamide activation

1997 • 132 citations

Separation of human liver microsomal tolbutamide hydroxylase and (S)-mephenytoin 4'-hydroxylase cytochrome P-450 enzymes.

1991 • 98 citations

The CYP2 family: models, mutants and interactions

1998 • 95 citations

Cloning and sequence determination of a complementary DNA related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase

1987 • 91 citations

Allelic and functional variability of cytochrome P4502C9

1997 • 86 citations

Stereochemistry of aromatic phenytoin hydroxylation in various drug hydroxylation phenotypes in humans.

1987 • 66 citations

In vitro oxidation of oxicam NSAIDs by a human liver cytochrome P450

1992 • 61 citations

Nucleotide Sequence of a Human Liver Cytochrome P-450 Related to the Rat Male Specific Form1

1987 • 53 citations

Purification of Human Liver Cytochrome P-450 Catalyzing Testosterone 6β-Hydroxylation1

1987 • 53 citations

Identification of Residues 286 and 289 as Critical for Conferring Substrate Specificity of Human CYP2C9 for Diclofenac and Ibuprofen

1998 • 50 citations

High–Level Expression of Human Lipocortin I in the Fission Yeast Schizosaccharomyces pombe Using a Novel Expression Vector

1994 • 50 citations

Simultaneous determination of citalopram and its metabolites by high-performance liquid chromatography with column switching and fluorescence detection by direct plasma injection

1995 • 46 citations