Cytochrome P450-dependent desaturation of lauric acid: isoform selectivity and mechanism of formation of 11-dodecenoic acid

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature

1996 • 2,895 citations

Cytochrome P-450: Structure, Mechanism, and Biochemistry

1986 • 2,703 citations

Role of Hemoprotein P-450 in Fatty Acid ω-Hydroxylation in a Soluble Enzyme System from Liver Microsomes

1968 • 625 citations

Purification and characterization of a unique isozyme of cytochrome P-450 from liver microsomes of ethanol-treated rabbits.

1982 • 537 citations

Allelic Variants of Human Cytochrome P450 2C9: Baculovirus-Mediated Expression, Purification, Structural Characterization, Substrate Stereoselectivity, and Prochiral Selectivity of the Wild-Type and I359L Mutant Forms

1996 • 256 citations

Cytochrome P-450—Catalyzed Formation of Δ ⁴ -VPA, a Toxic Metabolite of Valproic Acid

1987 • 248 citations

A nonsynchronous concerted mechanism for cytochrome P-450 catalyzed hydroxylation

1995 • 171 citations

Enzymic oxidation of ethyl carbamate to vinyl carbamate and its role as an intermediate in the formation of 1,N6-ethenoadenosine

1991 • 153 citations

Cytochrome P-450-catalyzed desaturation of valproic acid in vitro. Species differences, induction effects, and mechanistic studies.

1988 • 126 citations

Properties of electrophoretically homogeneous constitutive forms of liver microsomal cytochrome P-450.

1981 • 121 citations

Oxygen Activation and Reactivity

1995 • 119 citations

Isotopically sensitive branching and its effect on the observed intramolecular isotope effects in cytochrome P-450 catalyzed reactions: a new method for the estimation of intrinsic isotope effects

1986 • 99 citations

Cytochrome P-450 catalysis: radical intermediates and dehydrogenation reactions

1989 • 85 citations

Purification and properties of cytochrome P-450 obtained from liver microsomes of untreated rats by lauric acid affinity chromatography.

1978 • 81 citations

CYP4 Isoenzyme Specificity and the Relationship between .omega.-Hydroxylation and Terminal Desaturation of Valproic Acid

1995 • 78 citations

Expression of Rabbit Cytochromes P4504A Which Catalyze the ω-Hydroxylation of Arachidonic Acid, Fatty Acids, and Prostaglandins

1993 • 76 citations

Mechanistic Studies on the Cytochrome P450-Catalyzed Dehydrogenation of 3-Methylindole

1996 • 74 citations

Prostaglandin and Fatty Acid ω- and (ω-1)-Oxidation in Rabbit Lung

1989 • 69 citations

Primary structures of cytochrome P-450 isozyme 5 from rabbit and rat and regulation of species-dependent expression and induction in lung and liver: identification of cytochrome P-450 gene subfamily IVB.

1989 • 67 citations

Purification of liver microsomal cytochrome P-450 isozymes 3a and 6 from imidazole-treated rabbits. Evidence for the identity of isozyme 3a with the form obtained by ethanol treatment.

1984 • 65 citations

Identification and induction of cytochromes P450, P450IIE1 and P450IA1 in rabbit bone marrow.

1989 • 54 citations

Purification and properties of a cytochrome P450 arachidonic acid epoxygenase from rabbit renal cortex.

1992 • 50 citations

On the mechanism of amine oxidations by P450

1995 • 47 citations

Fatty Acid Interaction with the Hydroxylating Enzyme System of Rat Liver Microsomes

1969 • 41 citations

ω- and (ω − 1) -hydroxylation of arachidonic acid, lauric acid and prostaglandin A1 by multiple forms of cytochrome P-450 purified from rat hepatic microsomes

1990 • 38 citations

[41] ω- and (ω-1)-hydroxylation of eicosanoids and fatty acids by high-performance liquid chromatography

1991 • 31 citations

Effects of Steric Bulk and Conformational Rigidity on Fatty Acid Omega Hydroxylation by a Cytochrome P450 4A1 Fusion Protein

1996 • 29 citations

Chemical synthesis and cytotoxic properties of N-alkylcarbamic acid thioesters, metabolites of hepatotoxic formamides

1990 • 22 citations

Heme-Coordinating Analogs of Lauric Acid as Inhibitors of Fatty Acid ω-Hydroxylation

1997 • 19 citations

Characterization of Rabbit Liver P450IIE1 Synthesized in Transformed Yeast Cells1

1990 • 12 citations

CYP enzymes catalyze the formation of a terminal olefin from 2-ethylhexanoic acid in rat and human liver

1996 • 8 citations