Cystatin C deficiency in human atherosclerosis and aortic aneurysms

Stability and Instability: Two Faces of Coronary Atherosclerosis

1996 • 910 citations

Detection of activated T lymphocytes in the human atherosclerotic plaque.

1989 • 739 citations

Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation

1997 • 664 citations

Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells.

1998 • 646 citations

Serum cystatin C, determined by a rapid, automated particle-enhanced turbidimetric method, is a better marker than serum creatinine for glomerular filtration rate

1994 • 514 citations

Isolation of six cysteine proteinase inhibitors from human urine. Their physicochemical and enzyme kinetic properties and concentrations in biological fluids.

1986 • 499 citations

Macrophages and atherosclerotic plaque stability

1996 • 474 citations

Production and localization of 92-kilodalton gelatinase in abdominal aortic aneurysms. An elastolytic metalloproteinase expressed by aneurysm-infiltrating macrophages.

1995 • 452 citations

The serum concentration of active transforming growth factor-β is severely depressed in advanced atherosclerosis

1995 • 386 citations

Regulation of Matrix Metalloproteinase Expression in Human Vascular Smooth Muscle Cells by T Lymphocytes

1997 • 342 citations

Evidence for Altered Balance Between Matrix Metalloproteinases and Their Inhibitors in Human Aortic Diseases

1997 • 310 citations

Pericellular mobilization of the tissue-destructive cysteine proteinases, cathepsins B, L, and S, by human monocyte-derived macrophages.

1995 • 309 citations

Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease.

1992 • 304 citations

Role of Matrix Metalloproteinases in Abdominal Aortic Aneurysmsa

1996 • 304 citations

Expression of matrix metalloproteinases and their inhibitors in aneurysms and normal aorta

1997 • 297 citations

Local overexpression of TIMP-1 prevents aortic aneurysm degeneration and rupture in a rat model.

1998 • 294 citations

The place of human γ-trace (cystatin C) amongst the cysteine proteinase inhibitors

1984 • 294 citations

Enhanced Expression of Vascular Matrix Metalloproteinases Induced In Vitro by Cytokines and in Regions of Human Atherosclerotic Lesions^a

1994 • 272 citations

Circulating Cell Adhesion Molecules Are Correlated With Ultrasound-Based Assessment of Carotid Atherosclerosis

1998 • 263 citations

Emphysema: The First Two Centuries-and Beyond: A Historical Overview, with Suggestions for Future Research: Part

1992 • 189 citations

Extracellular Matrix Remodeling during Morphogenesis^a

1998 • 181 citations

Genomic instability in the type II TGF-beta1 receptor gene in atherosclerotic and restenotic vascular cells.

1997 • 171 citations

Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2

1995 • 167 citations

In Situ Localization and Quantification of mRNA for 92-kD Type IV Collagenase and Its Inhibitor in Aneurysmal, Occlusive, and Normal Aorta

1995 • 161 citations

Human atherosclerotic abdominal aortic aneurysms produce interleukin (IL)-6 and interferon-gamma but not IL-2 and IL-4: The possible role for IL-6 and interferon-gamma in vascular inflammation

1994 • 144 citations

New perspectives on basic mechanisms in lung disease. 6. Proteinase imbalance: its role in lung disease.

1993 • 141 citations

Up‐regulation of a serine protease inhibitor in astrocytes mediates the neuroprotective activity of transforming growth factor β1

1998 • 126 citations

Constitutive secretion of cystatin C (gamma-trace) by monocytes and macrophages and its downregulation after stimulation.

1987 • 126 citations

Proteases and Protease Inhibitors in Tumor Progression

1997 • 124 citations

Expression of Matrix Metalloproteinases and TIMPs in Human Abdominal Aortic Aneurysms

1998 • 121 citations

Prospective studies of C-reactive protein as a risk factor for cardiovascular disease.

1998 • 118 citations

Expression of Tissue Inhibitor of Metalloproteinases-3 in Human Atheroma and Regulation in Lesion-Associated Cells

1998 • 117 citations

Plasma Concentrations of Interleukin-6 and Abdominal Aortic Diameter Among Subjects Without Aortic Dilatation

1999 • 108 citations

Extracellular matrix degrading metalloproteinases in the pathogenesis of arteriosclerosis

1994 • 106 citations

Mammalian cysteine protease inhibitors: biochemical properties and possible roles in tumor progression.

1995 • 101 citations

Comparison of live human neutrophil and alveolar macrophage elastolytic activity in vitro. Relative resistance of macrophage elastolytic activity to serum and alveolar proteinase inhibitors.

1984 • 96 citations

Cysteine proteinases and cystatin C in bronchoalveolar lavage fluid from subjects with subclinical emphysema

1998 • 82 citations

Identification of Cystatin C, a Cysteine Proteinase Inhibitor, as a Major Secretory Product of Human Alveolar MacrophagesIn Vitro

1990 • 81 citations

Human cystatin C forms an inactive dimer during intracellular trafficking in transfected CHO cells

1997 • 73 citations

Cellular Components and Features of Immune Response in Abdominal Aortic Aneurysmsa

1996 • 71 citations

The human cystatin C gene (CST3), mutated in hereditary cystatin C amyloid angiopathy, is located on chromosome 20

1989 • 64 citations

Biochemistry and Molecular Regulation of Matrix Macromolecules in Abdominal Aortic Aneurysms

1996 • 63 citations

The human cystatin C gene promoter: Functional analysis and identification of heterogeneous mRNA

1995 • 55 citations

Up-regulation of tissue inhibitor of metalloproteinases-3 gene expression by TGF-β in articular chondrocytes is mediated by serine/threonine and tyrosine kinases

1998 • 46 citations

The Use of Monoclonal Antibodies to Define Levels of Cystatin C in Normal Human Serum

1989 • 45 citations

Diagnosis of cerebral amyloid angiopathy by enzyme-linked immunosorbent assay of cystatin C in cerebrospinal fluid.

1991 • 35 citations

Immunochemical quantitation of cysteine proteinase inhibitor cystatin C in inflamed human gingiva

1989 • 33 citations

Transforming growth factor-beta induces plasminogen activator inhibitor type-1 in cultured human orbital fibroblasts.

1995 • 31 citations

[15] Elastin degradation

1987 • 29 citations

Role of Serine Proteases in Aneurysm Developmenta

1996 • 28 citations

Cystatin C mutation causing amyloid angiopathy and brain hemorrhage.

1990 • 18 citations