Actin filament disassembly is a sufficient final trigger for exocytosis in nonexcitable cells.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

SNAP receptors implicated in vesicle targeting and fusion

1993 • 3,220 citations

A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion

1993 • 1,893 citations

Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores

1989 • 1,616 citations

The molecular machinery for secretion is conserved from yeast to neurons.

1993 • 658 citations

Structure of gelsolin segment 1-actin complex and the mechanism of filament severing

1993 • 574 citations

Plasma and cytoplasmic gelsolins are encoded by a single gene and contain a duplicated actin-binding domain

1986 • 477 citations

Actin-dependent organelle movement in squid axoplasm

1992 • 370 citations

The kinetics of chemotactic peptide-induced change in F-actin content, F-actin distribution, and the shape of neutrophils.

1985 • 319 citations

A novel 145 kd brain cytosolic protein reconstitutes Ca2+-regulated secretion in permeable neuroendocrine cells

1992 • 261 citations

Mechanism of the interaction of human platelet profilin with actin.

1991 • 235 citations

Gelsolin: Calcium‐ and polyphosphoinositide‐regulated actin‐ modulating protein

1987 • 228 citations

gCap39, a Calcium Ion- and Polyphosphoinositide-Regulated Actin Capping Protein

1990 • 225 citations

Identification of a polyphosphoinositide-binding sequence in an actin monomer-binding domain of gelsolin.

1992 • 224 citations

Cortical filamentous actin disassembly and scinderin redistribution during chromaffin cell stimulation precede exocytosis, a phenomenon not exhibited by gelsolin.

1991 • 223 citations

Expression of human plasma gelsolin in Escherichia coli and dissection of actin binding sites by segmental deletion mutagenesis.

1989 • 195 citations

Golgi-derived vesicles from developing epithelial cells bind actin filaments and possess myosin-I as a cytoplasmically oriented peripheral membrane protein.

1993 • 192 citations

Thymosin beta 10 and thymosin beta 4 are both actin monomer sequestering proteins.

1993 • 168 citations

Chemoattractant-stimulated polymorphonuclear leukocytes contain two populations of actin filaments that differ in their spatial distributions and relative stabilities.

1990 • 165 citations

SAC1p is an integral membrane protein that influences the cellular requirement for phospholipid transfer protein function and inositol in yeast

1993 • 163 citations

Thymosin beta 4 sequesters the majority of G-actin in resting human polymorphonuclear leukocytes.

1992 • 158 citations

Interaction of thymosin .beta.4 with muscle and platelet actin: implications for actin sequestration in resting platelets

1992 • 153 citations

Thymosin beta 4 (Fx peptide) is a potent regulator of actin polymerization in living cells.

1992 • 153 citations

Role of free cytosolic calcium in secretagogue-stimulated amylase release from dispersed acini from guinea pig pancreas.

1985 • 150 citations

Peripheral actin filaments control calcium-mediated catecholamine release from streptolysin-O-permeabilized chromaffin cells.

1988 • 137 citations

Actin filament organization in activated mast cells is regulated by heterotrimeric and small GTP-binding proteins.

1994 • 135 citations

Changes in the state of actin during the exocytotic reaction of permeabilized rat mast cells.

1990 • 124 citations

Small actin-binding proteins: the β-thymosin family

1993 • 119 citations

Effects of caerulein on the apical cytoskeleton of the pancreatic acinar cell.

1990 • 117 citations

A synthetic peptide of the rab3a effector domain stimulates amylase release from permeabilized pancreatic acini.

1992 • 117 citations

The dynamics of exocytosis in human neutrophils.

1988 • 109 citations

Synaptotagmin: A calcium-sensitive inhibitor of exocytosis?

1993 • 107 citations

Isolation and properties of two actin-binding domains in gelsolin.

1985 • 105 citations

Gelsolin inhibition of fast axonal transport indicates a requirement for actin microfilaments

1984 • 104 citations

Ca(2+)-dependent kinase and phosphatase control inositol 1,4,5-trisphosphate-mediated Ca2+ release. Modification by agonist stimulation

1993 • 101 citations

Effects of thymosin β4 and thymosin β10 on actin structures in living cells

1994 • 98 citations

Microfilamentous system and secretion of enzyme in the exocrine pancreas. Effect of cytochalasin B.

1975 • 97 citations

Destabilization of actin filaments as a requirement for the secretion of catecholamines from permeabilized chromaffin cells

1986 • 94 citations

Focusing on unpolymerized actin.

1993 • 94 citations

Cholecystokinin and regulation of pancreatic acinar cell function

1993 • 94 citations

Actin Involvement in Exocytosis from PC12 Cells: Studies on the Influence of Botulinum C2 Toxin on Stimulated Noradrenaline Release

1989 • 86 citations

The actin released from profilin--actin complexes is insufficient to account for the increase in F-actin in chemoattractant-stimulated polymorphonuclear leukocytes.

1990 • 85 citations

Dynamic changes in chromaffin cell cytoskeleton as prelude to exocytosis

1992 • 83 citations

Solution conformation of thymosin .beta.4: a nuclear magnetic resonance and simulated annealing study

1990 • 79 citations

Monokines Mediate Decreased Hepatic Glucocorticoid Binding in Endotoxemia

1991 • 68 citations

The synaptic vesicle protein synaptotagmin promotes formation of filopodia in fibroblasts

1993 • 63 citations

Protein tyrosine phosphatase stimulates Ca(2+)-dependent amylase secretion from pancreatic acini.

1991 • 52 citations

Characterization of tetramethylrhodaminyl‐phalloidin binding to cellular F‐actin

1992 • 51 citations

Receptors and Cell Activation Associated with Pancreatic Enzyme Secretion

1986 • 49 citations

Cholecystokinin JMV-180 and Caerulein Effects on the Pancreatic Acinar Cell Cytoskeleton

1993 • 45 citations

Amylase release from streptolysin O-permeabilized pancreatic acini

1990 • 31 citations

Interactions of intracellular mediators of amylase secretion in permeabilized pancreatic acini

1991 • 15 citations

The ins and outs of Ca2+ in exocrine cells.

1992 • 9 citations

Contractile Proteins in Chromaffin Cells

1983 • 8 citations

Identification of Proteins Required for Ca²⁺‐activated Secretion^a

1994 • 6 citations