A herpesvirus regulatory protein appears to act post-transcriptionally by affecting mRNA processing.

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

A Method for Isolation of Intact, Translationally Active Ribonucleic Acid

1983 • 1,469 citations

Spliced segments at the 5′ terminus of adenovirus 2 late mRNA

1977 • 1,301 citations

The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA

1989 • 1,280 citations

An amazing sequence arrangement at the 5′ ends of adenovirus 2 messenger RNA

1977 • 1,138 citations

Identification of two distinct regulatory regions adjacent to the human β-interferon gene

1983 • 1,076 citations

A cDNA cloning vector that permits expression of cDNA inserts in mammalian cells.

1983 • 933 citations

A novel rapid assay for chloramphenicol acetyltransferase gene expression

1987 • 802 citations

The consensus sequence YGTGTTYY located downstream from the AATAAA signal is required for efficient formation of mRNA 3′ termini

1985 • 652 citations

Analysis of transcriptional regulatory signals of the HSV thymidine kinase gene: Identification of an upstream control region

1981 • 646 citations

rev protein of human immunodeficiency virus type 1 affects the stability and transport of the viral mRNA.

1989 • 634 citations

Regulation by HIV Rev depends upon recognition of splice sites

1989 • 517 citations

COMPLEX TRANSCRIPTIONAL UNITS: DIVERSITY IN GENE EXPRESSION BY ALTERNATIVE RNA PROCESSING

1986 • 486 citations

Herpes simplex virus type 1 ICP27 is an essential regulatory protein

1985 • 462 citations

Regulatory pathways governing HIV-1 replication

1989 • 401 citations

The rev gene product of the human immunodeficiency virus affects envelope-specific RNA localization

1989 • 400 citations

Trans activation of transcription by herpes virus products: requirement for two HSV-1 immediate-early polypeptides for maximum activity.

1984 • 396 citations

Herpes simplex virus virion host shutoff function

1988 • 350 citations

Evidence for a direct role for both the 175,000- and 110,000-molecular-weight immediate-early proteins of herpes simplex virus in the transactivation of delayed-early promoters

1985 • 345 citations

Herpes simplex virus type 1 ICP27 deletion mutants exhibit altered patterns of transcription and are DNA deficient

1989 • 329 citations

Herpes simplex virus mutants defective in the virion-associated shutoff of host polypeptide synthesis and exhibiting abnormal synthesis of alpha (immediate early) viral polypeptides

1983 • 293 citations

Evidence that the herpes simplex virus immediate early protein ICP27 acts post-transcriptionally during infection to regulate gene expression

1992 • 280 citations

REGULATED mRNA STABILITY

1990 • 279 citations

Requirement of a downstream sequence for generation of a poly(A) addition site

1984 • 261 citations

Regulation of adenovirus-2 gene expression at the level of transcriptional termination and RNA processing

1981 • 261 citations

Sequence at the 3′ end of globin mRNA shows homology with immunoglobulin light chain mRNA

1974 • 256 citations

Herpes simplex virus phosphoproteins. I. Phosphate cycles on and off some viral polypeptides and can alter their affinity for DNA

1980 • 251 citations

A sequence downstream of AAUAAA is required for rabbit β-globin mRNA 3′-end formation

1984 • 251 citations

Genetic evidence for two distinct transactivation functions of the herpes simplex virus alpha protein ICP27

1990 • 247 citations

Transcripts from the adenovirus-2 major late promoter yield a single early family of 3′ coterminal mRNAs and five late families

1980 • 235 citations

Detailed analysis of the portion of the herpes simplex virus type 1 genome encoding glycoprotein C

1983 • 230 citations

Regulation of cytomegalovirus gene expression: alpha and beta promoters are trans activated by viral functions in permissive human fibroblasts

1985 • 229 citations

The herpes simplex virus type 1 alpha protein ICP27 can act as a trans-repressor or a trans-activator in combination with ICP4 and ICP0

1988 • 202 citations

Characterization of the IE110 Gene of Herpes Simplex Virus Type 1

1986 • 192 citations

Nucleotide sequence specifying the glycoprotein gene, gB, of herpes simplex virus type 1

1984 • 192 citations

Characterization of herpes simplex virus 1 alpha proteins 0, 4, and 27 with monoclonal antibodies

1984 • 184 citations

Individual HSV Transcripts

1985 • 176 citations

The adenovirus E1B 55 kd protein influences mRNA transport via an intranuclear effect on RNA metabolism.

1989 • 169 citations

Gene-specific transactivation by herpes simplex virus type 1 alpha protein ICP27

1988 • 167 citations

The Products of Herpes Simplex Virus Type 1 (HSV-1) Immediate Early Genes 1, 2 and 3 Can Activate HSV-1 Gene Expression in trans

1986 • 163 citations

Effects of herpes simplex virus on mRNA stability

1987 • 151 citations

Cloning of the protective antigen gene of Bacillus anthracis

1983 • 144 citations

A detailed mutational analysis of Vmw110, a trans-acting transcriptional activator encoded by herpes simplex virus type 1.

1987 • 135 citations

DNA fragments from F9 PyEC mutants increase expression of heterologous genes in transfected F9 cells

1983 • 134 citations

The repressing and enhancing functions of the herpes simplex virus regulatory protein ICP27 map to C-terminal regions and are required to modulate viral gene expression very early in infection

1990 • 124 citations

The Epstein-Barr virus (EBV) early protein EB2 is a posttranscriptional activator expressed under the control of EBV transcription factors EB1 and R

1989 • 110 citations

A negative regulatory element in the human papillomavirus type 16 genome acts at the level of late mRNA stability

1991 • 106 citations

Co-ordinate regulation of herpes simplex virus gene expression is mediated by the functional interaction of two immediate early gene products

1986 • 105 citations

Translational control of cytomegalovirus gene expression is mediated by upstream AUG codons

1988 • 104 citations

Synthesis of Virus-Specific Ribonucleic Acid in KB Cells Infected with Type 2 Adenovirus

1971 • 94 citations

Comparison of upstream sequence requirements for positive and negative regulation of a herpes simplex virus immediate-early gene by three virus-encoded trans-acting factors

1987 • 92 citations

Herpes simplex virus alpha protein ICP27 possesses separable positive and negative regulatory activities

1989 • 92 citations

A mutant of herpes simplex virus type 1 exhibits increased stability of immediate-early (alpha) mRNAs

1987 • 88 citations

The Simian Virus 40 Small-t Intron, Present in Many Common Expression Vectors, Leads to Aberrant Splicing

1990 • 88 citations

Herpes simplex virus induces a processing factor that stimulates poly(A) site usage

1989 • 84 citations

The regions important for the activator and repressor functions of herpes simplex virus type 1 alpha protein ICP27 map to the C-terminal half of the molecule

1989 • 83 citations

Transactivation of plasmid-borne promoters by adenovirus and several herpes group viruses

1984 • 81 citations

Redistribution of nuclear ribonucleoprotein antigens during herpes simplex virus infection.

1987 • 81 citations

The Epstein-Barr virus immediate-early gene product, BMLF1, acts in trans by a posttranscriptional mechanism which is reporter gene dependent

1989 • 71 citations

Post-transcriptional control of human cytomegalovirus gene expression

1983 • 69 citations

Splice site selection dominates over poly(A) site choice in RNA production from complex adenovirus transcription units.

1988 • 64 citations

Discordant expression of the immediate-early 1 and 2 gene regions of human cytomegalovirus at early times after infection involves posttranscriptional processing events

1991 • 61 citations

A mutant herpesvirus protein leads to a block in nuclear localization of other viral proteins.

1986 • 59 citations

Expression of herpes simplex virus beta and gamma genes integrated in mammalian cells and their induction by an alpha gene product.

1983 • 56 citations

Expression of a Human Cytomegalovirus Late Gene Is Posttranscriptionally Regulated by a 3′-End-Processing Event Occurring Exclusively Late After Infection

1986 • 49 citations

Polyomavirus early-late switch is not regulated at the level of transcription initiation and is associated with changes in RNA processing.

1988 • 46 citations

Virus-induced modification of the host cell is required for expression of the bacterial chloramphenicol acetyltransferase gene controlled by a late herpes simplex virus promoter (VP5)

1985 • 43 citations

A journal of exciting biology

1974 • 41 citations

Mutations in the activation region of herpes simplex virus regulatory protein ICP27 can be trans dominant

1991 • 41 citations

Effect of RNA secondary structure on polyadenylation site selection.

1991 • 40 citations

A single regulatory region modulates both cis activation and trans activation of the herpes simplex virus VP5 promoter in transient-expression assays in vivo

1986 • 28 citations

Promoter-independent activation of heterologous virus gene expression by the herpes simplex virus immediate-early protein ICP27

1992 • 26 citations

Change of processing and nucleocytoplasmic transport of mRNA in HSV-1-infected cells

1989 • 23 citations

Splice site requirement for the efficient accumulation of polyoma virus late mRNAs

1991 • 14 citations

Herpes simplex virus type 1 alpha gene containing plasmids can inhibit expression regulated from an alpha promoter in CV-1 but not HeLa cells

1988 • 12 citations

Inefficiency of expression of luciferase reporter from transfected murine leukaemia proviral DNA may be partially overcome by providing a strong polyadenylation signal

1991 • 5 citations

Activation of gene expression by human herpesvirus 6 is reporter gene-dependent

1991 • 3 citations