The repressing and enhancing functions of the herpes simplex virus regulatory protein ICP27 map to C-terminal regions and are required to modulate viral gene expression very early in infection

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

The Complete DNA Sequence of the Long Unique Region in the Genome of Herpes Simplex Virus Type 1

1988 • 1,618 citations

Regulation of Herpesvirus Macromolecular Synthesis I. Cascade Regulation of the Synthesis of Three Groups of Viral Proteins

1974 • 1,479 citations

Isolation and characterization of deletion mutants of herpes simplex virus type 1 in the gene encoding immediate-early regulatory protein ICP4

1985 • 702 citations

Regulation of herpesvirus macromolecular synthesis: sequential transition of polypeptide synthesis requires functional viral polypeptides.

1975 • 616 citations

Identification of herpes simplex virus DNA sequences which encode a trans-acting polypeptide responsible for stimulation of immediate early transcription

1984 • 567 citations

Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1

1985 • 523 citations

Control of herpes simplex virus type 1 mRNA synthesis in cells infected with wild-type virus or the temperature-sensitive mutant tsK

1979 • 496 citations

Herpes simplex virus type 1 ICP27 is an essential regulatory protein

1985 • 462 citations

Fine-structure mapping and functional analysis of temperature-sensitive mutants in the gene encoding the herpes simplex virus type 1 immediate early protein VP175

1980 • 436 citations

Characterization of the herpes simplex virion-associated factor responsible for the induction of alpha genes

1983 • 423 citations

Isolation and Characterization of a Herpes Simplex Virus Type 1 Mutant Containing a Deletion within the Gene Encoding the Immediate Early Polypeptide Vmw110

1986 • 422 citations

Trans activation of transcription by herpes virus products: requirement for two HSV-1 immediate-early polypeptides for maximum activity.

1984 • 396 citations

Multiple functional domains in the adenovirus E1A gene

1987 • 361 citations

Evidence for a direct role for both the 175,000- and 110,000-molecular-weight immediate-early proteins of herpes simplex virus in the transactivation of delayed-early promoters

1985 • 345 citations

Complete DNA sequence of the short repeat region in the genome of herpes simplex virus type 1

1986 • 335 citations

Deletion mutants in the gene encoding the herpes simplex virus type 1 immediate-early protein ICP0 exhibit impaired growth in cell culture

1987 • 333 citations

Herpes simplex virus type 1 ICP27 deletion mutants exhibit altered patterns of transcription and are DNA deficient

1989 • 329 citations

An adenovirus E1a protein region required for transformation and transcriptional repression

1986 • 329 citations

Three trans-acting regulatory proteins of herpes simplex virus modulate immediate-early gene expression in a pathway involving positive and negative feedback regulation

1985 • 285 citations

Temporal regulation of herpes simplex virus type 1 transcription: location of transcripts on the viral genome

1977 • 274 citations

Activation of Immediate-Early, Early, and Late Promoters by Temperature-Sensitive and Wild-Type Forms of Herpes Simplex Virus Type 1 Protein ICP4

1985 • 273 citations

Identification of immediate early genes from herpes simplex virus that transactivate the virus thymidine kinase gene.

1985 • 267 citations

Regulation of herpesvirus macromolecular synthesis V. Properties of α polypeptides made in HSV-1 and HSV-2 infected cells

1977 • 253 citations

Herpes simplex virus phosphoproteins. I. Phosphate cycles on and off some viral polypeptides and can alter their affinity for DNA

1980 • 251 citations

Herpes simplex virus 1 mutant deleted in the alpha 22 gene: growth and gene expression in permissive and restrictive cells and establishment of latency in mice

1985 • 243 citations

Stimulation of expression of a herpes simplex virus DNA-binding protein by two viral functions.

1985 • 242 citations

Herpes simplex virus type 1 ICP0 plays a critical role in the de novo synthesis of infectious virus following transfection of viral DNA

1989 • 237 citations

Physical and functional domains of the herpes simplex virus transcriptional regulatory protein ICP4

1988 • 225 citations

The herpes simplex virus type 1 alpha protein ICP27 can act as a trans-repressor or a trans-activator in combination with ICP4 and ICP0

1988 • 202 citations

Activities of herpes simplex virus type 1 (HSV-1) ICP4 genes specifying nonsense peptides

1987 • 183 citations

Individual HSV Transcripts

1985 • 176 citations

The DNA Sequences of the Long Repeat Region and Adjoining Parts of the Long Unique Region in the Genome of Herpes Simplex Virus Type 1

1988 • 172 citations

Regulation of herpesvirus macromolecular synthesis. VIII. The transcription program consists of three phases during which both extent of transcription and accumulation of RNA in the cytoplasm are regulated

1979 • 169 citations

Gene-specific transactivation by herpes simplex virus type 1 alpha protein ICP27

1988 • 167 citations

Stimulation of Expression of a Herpes Simplex Virus DNA-Binding Protein by Two Viral Functions

1985 • 165 citations

The Products of Herpes Simplex Virus Type 1 (HSV-1) Immediate Early Genes 1, 2 and 3 Can Activate HSV-1 Gene Expression in trans

1986 • 163 citations

Evidence that herpes simplex virus DNA is transcribed by cellular RNA polymerase B

1977 • 163 citations

Generation of an inverting herpes simplex virus 1 mutant lacking the L-S junction a sequences, an origin of DNA synthesis, and several genes including those specifying glycoprotein E and the alpha 47 gene

1986 • 159 citations

Viral DNA synthesis is required for the efficient expression of specific herpes simplex virus type 1 mRNA species

1980 • 152 citations

The DNA-Binding Properties of the Major Regulatory Protein α4 of Herpes Simplex Viruses

1988 • 144 citations

A detailed mutational analysis of Vmw110, a trans-acting transcriptional activator encoded by herpes simplex virus type 1.

1987 • 135 citations

Collaborative complementation study of temperature-sensitive mutants of herpes simplex virus types 1 and 2

1978 • 132 citations

Temperature-sensitive mutants in herpes simplex virus type 1 ICP4 permissive for early gene expression

1984 • 122 citations

Genetic Relations between Varicella-Zoster Virus and Epstein-Barr Virus

1987 • 113 citations

Regulation of herpes simplex virus 1 genes: α gene sequence requirements for transient induction of indicator genes regulated by β or late (γ2) promoters

1986 • 98 citations

Herpes simplex Virus a Protein ICP27 Can Inhibit or Augment Viral Gene Transactivation

1989 • 94 citations

Herpes simplex virus alpha protein ICP27 possesses separable positive and negative regulatory activities

1989 • 92 citations

Transcription of herpes simplex type 1 DNA in nuclei isolated from infected HEp-2 and KB cells

1974 • 90 citations

Mutational dissection of the HSV-1 immediate-early protein Vmw175 involved in transcriptional transactivation and repression

1988 • 88 citations

The regions important for the activator and repressor functions of herpes simplex virus type 1 alpha protein ICP27 map to the C-terminal half of the molecule

1989 • 83 citations

Conservation of gene organization in the lymphotropic herpesviruses herpesvirus Saimiri and Epstein-Barr virus

1988 • 72 citations

Regulation of the herpes simplex virus type 1 late (γ₂) glycoproteln C gene: sequences between base pairs −34 to +29 control transient expression and responsiveness to transactivation by the products of the immediate early (α) 4 and 0 genes

1987 • 65 citations

Properties of herpesvirus-induced “immediate early” polypeptides

1980 • 59 citations

Promoter sequence and cell type can dramatically affect the efficiency of transcriptional activation induced by herpes simplex virus type 1 and its immediate-early gene products Vmw175 and Vmw110

1988 • 39 citations

The herpes simplex virus type 1 immediate-early protein icp27 is obligately required for the accumulation of a cellular protein during viral infection

1989 • 14 citations