Centrosomes Split in the Presence of Impaired DNA Integrity during Mitosis

Checkpoints: Controls That Ensure the Order of Cell Cycle Events

1989 • 3,036 citations

Cell Cycle Checkpoints: Preventing an Identity Crisis

1996 • 2,056 citations

Centrosome Amplification and a Defective G2–M Cell Cycle Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform–Deficient Cells

1999 • 814 citations

Abnormal Centrosome Amplification in the Absence of p53

1996 • 802 citations

Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

2002 • 651 citations

Pericentrin, a highly conserved centrosome protein involved in microtubule organization

1994 • 579 citations

Centrosome amplification drives chromosomal instability in breast tumor development

2002 • 564 citations

Centrosome hypertrophy in human breast tumors: Implications for genomic stability and cell polarity

1998 • 515 citations

Requirement of Cdk2-Cyclin E Activity for Repeated Centrosome Reproduction in Xenopus Egg Extracts

1999 • 505 citations

The Respective Contributions of the Mother and Daughter Centrioles to Centrosome Activity and Behavior in Vertebrate Cells

2000 • 462 citations

UCN-01: a Potent Abrogator of G2 Checkpoint Function in Cancer Cells With Disrupted p53

1996 • 451 citations

The Mitotic Spindle: A Self-Made Machine

2001 • 447 citations

Cyclin-dependent kinase control of centrosome duplication

1999 • 423 citations

A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators

1998 • 419 citations

γ-Tubulin is present in Drosophila melanogaster and homo sapiens and is associated with the centrosome

1991 • 405 citations

Managing the centrosome numbers game: from chaos to stability in cancer cell division

2001 • 402 citations

Centrosome-Dependent Exit of Cytokinesis in Animal Cells

2001 • 396 citations

Centrosome organization and centriole architecture: Their sensitivity to divalent cations

1992 • 365 citations

Checking out the G2/M transition

2001 • 345 citations

Centrosomes Enhance the Fidelity of Cytokinesis in Vertebrates and Are Required for Cell Cycle Progression

2001 • 340 citations

The Sudden Recruitment of γ-Tubulin to the Centrosome at the Onset of Mitosis and Its Dynamic Exchange Throughout the Cell Cycle, Do Not Require Microtubules

1999 • 339 citations

Requirement of a Centrosomal Activity for Cell Cycle Progression Through G ₁ into S Phase

2001 • 336 citations

It takes two to tango

2003 • 335 citations

Caffeine-Induced Uncoupling of Mitosis from the Completion of DNA Replication in Mammalian Cells

1986 • 328 citations

Cell Cycle-Dependent Changes in Microtubule Dynamics in Living Cells Expressing Green Fluorescent Protein-α Tubulin

2001 • 324 citations

Dissociation of centrosome replication events from cycles of DNA synthesis and mitotic division in hydroxyurea-arrested Chinese hamster ovary cells.

1995 • 301 citations

Cyclin B2 undergoes cell cycle-dependent nuclear translocation and, when expressed as a non-destructible mutant, causes mitotic arrest in HeLa cells

1992 • 298 citations

“It Takes Two to Tango”: understanding how centrosome duplication is regulated throughout the cell cycle

2001 • 279 citations

Mammalian recombination-repair genes XRCC2 and XRCC3 promote correct chromosome segregation

2000 • 234 citations

The centrosome in vertebrates: more than a microtubule-organizing center

2001 • 232 citations

Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle

1999 • 201 citations

Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation

2002 • 194 citations

Multiple centrosomes arise from tetraploidy checkpoint failure and mitotic centrosome clusters in p53 and RB pocket protein-compromised cells

2002 • 186 citations

NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1

2000 • 183 citations

Centrosome cohesion is regulated by a balance of kinase and phosphatase activities

2001 • 182 citations

The centrosome cycle

2002 • 163 citations

Direct regulation of the centrosome duplication cycle by the p53-p21Waf1/Cip1 pathway

2001 • 145 citations

NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1

2000 • 144 citations

DNA-replication/DNA-damage-dependent centrosome inactivation in Drosophila embryos

2000 • 142 citations

The checkpoint control for anaphase onset does not monitor excess numbers of spindle poles or bipolar spindle symmetry

1997 • 121 citations

Centriole distribution during tripolar mitosis in Chinese hamster ovary cells.

1984 • 112 citations

UCN-01 Abrogates G2 Arrest through a Cdc2-dependent Pathway That Is Associated with Inactivation of the Wee1Hu Kinase and Activation of the Cdc25C Phosphatase

1998 • 102 citations

The Coordination of Centrosome Reproduction with Nuclear Events of the Cell Cycle in the Sea Urchin Zygote

1998 • 90 citations

Centrosome Duplication

2001 • 85 citations

Centriole and Centrosome Dynamics during the Embryonic Cell Cycles That Follow the Formation of the Cellular Blastoderm inDrosophila

1997 • 77 citations

γ-Tubulin

1999 • 72 citations

Do Centrosome Abnormalities Lead to Cancer?

2001 • 70 citations

Differences in the regulation of protein synthesis, cyclin B accumulation, and cellular growth in response to the inhibition of DNA synthesis in Chinese hamster ovary and HeLa S3 cells.

1993 • 61 citations

Role for microtubules in centrosome doubling in chinese hamster ovary cells

1999 • 58 citations

p53 Mutation and Mitotic Infidelity

2000 • 52 citations

Mitotic Regulators Govern Progress through Steps in the Centrosome Duplication Cycle

1999 • 51 citations

Mitosis in cells with unreplicated genomes (MUGs): Spindle assembly and behavior of centromere fragments

1997 • 49 citations

Cell cycle dependent changes in microtubule dynamics in living cells expressing GFP-alpha tubulin

2000 • 46 citations

Saponin pre-treatment in pre-embedding electron microscopic in situ hybridization for detection of specific RNA sequences in cultured cells: a methodological study.

1995 • 18 citations