Peptide-induced T cell regulation of experimental autoimmune encephalomyelitis: a role for IL-10

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.

1991 • 3,812 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

1991 • 1,950 citations

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

1993 • 1,219 citations

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo

1994 • 967 citations

Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells.

1996 • 788 citations

Peripheral deletion of antigen-reactive T cells in oral tolerance

1995 • 775 citations

Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering.

1992 • 734 citations

Induction of T _H 1 and T _H 2 Immunity in Neonatal Mice

1996 • 671 citations

T Cell Deletion in High Antigen Dose Therapy of Autoimmune Encephalomyelitis

1994 • 530 citations

Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction

1991 • 523 citations

IL-10 inhibits human T cell proliferation and IL-2 production.

1992 • 491 citations

Low avidity recognition of self-antigen by T cells permits escape from central tolerance

1995 • 415 citations

Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23).

1996 • 415 citations

Inhibition of T cell and antibody responses to house dust mite allergen by inhalation of the dominant T cell epitope in naive and sensitized mice.

1993 • 334 citations

Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4.

1995 • 323 citations

Selective anergy of V beta 8+,CD4+ T cells in Staphylococcus enterotoxin B-primed mice.

1990 • 312 citations

MHC-Restricted Depletion of Human Myelin Basic Protein-Reactive T Cells by T Cell Vaccination

1993 • 286 citations

Inhibition of experimental autoimmune encephalomyelitis by inhalation but not oral administration of the encephalitogenic peptide: influence of MHC binding affinity

1993 • 280 citations

The fate of self-reactive B cells depends primarily on the degree of antigen receptor engagement and availability of T cell help.

1996 • 251 citations

T cell recognition as the target for immune intervention in autoimmune disease

1989 • 218 citations

Use of adoptive transfer of T‐cell antigen‐receptor‐transgenic T cells for the study of T‐cell activation in vivo

1997 • 205 citations

Selective development of T helper (Th)2 cells induced by continuous administration of low dose soluble proteins to normal and beta(2)-microglobulin-deficient BALB/c mice.

1996 • 198 citations

Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis.

1996 • 196 citations

Treatment of Experimental Autoimmune Encephalomyelitis with Genetically Modified Memory T Cells

1997 • 180 citations

A single amino acid change in a myelin basic protein peptide confers the capacity to prevent rather than induce experimental autoimmune encephalomyelitis.

1991 • 165 citations

Aqueous antigens induce in vivo tolerance selectively in IL-2- and IFN-gamma-producing (Th1) cells.

1992 • 163 citations

Conditions That Induce Tolerance in Mature CD4+ T Cells

1997 • 149 citations

Mucosal tolerance and suppression of collagen-induced arthritis (CIA) induced by nasal inhalation of synthetic peptide 184-198 of bovine type II collagen (CII) expressing a dominant T cell epitope

1996 • 140 citations

Regulation of house dust mite responses by intranasally administered peptide: transient activation of CD4⁺ T cells precedes the development of tolerance in vivo

1996 • 137 citations

Immunoregulatory role of IL-10 during superantigen-induced hyporesponsiveness in vivo.

1997 • 135 citations

Limited capacity for tolerization of CD4+ T cells specific for a pancreatic β cell neo-antigen

1995 • 121 citations

Peptide-induced nasal tolerance for a mycobacterial heat shock protein 60 T cell epitope in rats suppresses both adjuvant arthritis and nonmicrobially induced experimental arthritis

1997 • 118 citations

Hierarchy in the ability of T cell epitopes to induce peripheral tolerance to antigens from myelin

1998 • 101 citations

Incorporation of cells into an ELISA system enhances antigen-driven lymphokine detection

1997 • 76 citations

Induction of Apoptosis and T Helper 2 (Th2) Responses Correlates with Peptide Affinity for the Major Histocompatibility Complex in Self-reactive T Cell Receptor Transgenic Mice

1997 • 75 citations

Affinity for class II MHC determines the extent to which soluble peptides tolerize autoreactive T cells in naive and primed adult mice—implications for autoimmunity

1995 • 71 citations

Suppression of murine collagen‐induced arthritis by nasal administration of collagen

1997 • 64 citations

Characterization of apoptosis-resistant antigen-specific T cells in vivo.

1996 • 63 citations

Intranasal administration of retinal antigens suppresses retinal antigen-induced experimental autoimmune uveoretinitis.

1994 • 60 citations

Mucosal Tolerance in a Murine Model of Experimental Autoimmune Encephalomyelitisa

1996 • 55 citations

Cell-cell interactions in the T cell proliferative response. I. Analysis of the cell types involved and evidence for nonspecific T cell recruitment.

1980 • 54 citations

Visualization of antigen-specific T cell activation and cytokine expression in vivo.

1997 • 53 citations

Peptide induced nasal tolerance for a mycobacterial hsp60 T cell epitope in rats suppresses both adjuvant arthritis and non-mycobacterially induced arthritis.

1997 • 53 citations

Soluble protein but not peptide administration diverts the immune response of a clonal CD4+ T cell population to the T helper 2 cell pathway.

1996 • 44 citations

Specific T-cell tolerance may reflect selective activation of lymphokine synthesis.

1995 • 29 citations

Treatment of murine experimental autoimmune encephalomyelitis with a myelin basic protein peptide analog alters the cellular composition of leukocytes infiltrating the cerebrospinal fluid

1998 • 19 citations

Deleted Work

1955 • 0 citations