Peptide-induced nasal tolerance for a mycobacterial heat shock protein 60 T cell epitope in rats suppresses both adjuvant arthritis and nonmicrobially induced experimental arthritis

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Autoimmunity to type II collagen an experimental model of arthritis.

1977 • 1,599 citations

Immunological Aspects of Demyelinating Diseases

1992 • 1,021 citations

Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens

1994 • 895 citations

Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis

1988 • 838 citations

Peripheral deletion of antigen-reactive T cells in oral tolerance

1995 • 775 citations

Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering.

1992 • 734 citations

Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain.

1992 • 726 citations

Induction of anergy or active suppression following oral tolerance is determined by antigen dosage.

1994 • 643 citations

Effects of Oral Administration of Type II Collagen on Rheumatoid Arthritis

1993 • 634 citations

Double-Blind Pilot Trial of Oral Tolerization with Myelin Antigens in Multiple Sclerosis

1993 • 592 citations

T Cell Deletion in High Antigen Dose Therapy of Autoimmune Encephalomyelitis

1994 • 530 citations

Arthritis induced by a T-lymphocyte clone that responds to Mycobacterium tuberculosis and to cartilage proteoglycans.

1985 • 463 citations

Oral tolerance in experimental autoimmune encephalomyelitis. III. Evidence for clonal anergy.

1991 • 450 citations

Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes.

1996 • 428 citations

Lines of T Lymphocytes Induce or Vaccinate Against Autoimmune Arthritis

1983 • 418 citations

Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23).

1996 • 415 citations

Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein and its fragments.

1988 • 404 citations

Inhibition of T cell and antibody responses to house dust mite allergen by inhalation of the dominant T cell epitope in naive and sensitized mice.

1993 • 334 citations

Peptide binding specificity of HLA-DR4 molecules: correlation with rheumatoid arthritis association.

1995 • 310 citations

Inhibition of S-antigen induced experimental autoimmune uveoretinitis by oral induction of tolerance with S-antigen.

1990 • 288 citations

Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. II. Suppression of disease and in vitro immune responses is mediated by antigen-specific CD8+ T lymphocytes.

1989 • 284 citations

Peripheral T-cell tolerance induced in naive and primed mice by subcutaneous injection of peptides from the major cat allergen Fel d I.

1993 • 280 citations

Inhibition of experimental autoimmune encephalomyelitis by inhalation but not oral administration of the encephalitogenic peptide: influence of MHC binding affinity

1993 • 280 citations

Activation of T cells recognizing self 60-kD heat shock protein can protect against experimental arthritis.

1995 • 263 citations

Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells.

1996 • 260 citations

Direct evidence for anergy in T lymphocytes tolerized by oral administration of ovalbumin

1993 • 233 citations

T cell priming versus T cell tolerance induced by synthetic peptides.

1995 • 230 citations

Lymphocyte recruitment in delayed-type hypersensitivity. The role of IFN-gamma.

1988 • 170 citations

Epitopes of myelin basic protein that trigger TGF-beta release after oral tolerization are distinct from encephalitogenic epitopes and mediate epitope-driven bystander suppression.

1993 • 158 citations

Adjuvant polyarthritis iv. induction by a synthetic adjuvant: immunologic, histopathologic, and other studies

1980 • 146 citations

Mucosal tolerance and suppression of collagen-induced arthritis (CIA) induced by nasal inhalation of synthetic peptide 184-198 of bovine type II collagen (CII) expressing a dominant T cell epitope

1996 • 140 citations

Differential mycobacterial 65-kDa heat shock protein T cell epitope recognition after adjuvant arthritis-inducing or protective immunization protocols.

1994 • 110 citations

Passive Transfer of Adjuvant-induced Arthritis and Allergic Encephalomyelitis in Rats using Thoracic Duct Lymphocytes

1969 • 96 citations

Nasal administration of retinal antigens suppresses the inflammatory response in experimental allergic uveoretinitis. A preliminary report of intranasal induction of tolerance with retinal antigens.

1993 • 87 citations

Peripheral tolerance of T_h2 lymphocytes induced by continuous feeding of ovalbumin

1996 • 80 citations

Affinity for class II MHC determines the extent to which soluble peptides tolerize autoreactive T cells in naive and primed adult mice—implications for autoimmunity

1995 • 71 citations

A vridine-induced arthritis in rats; a T cell-dependent chronic disease influenced both by MHC genes and by non-MHC genes

1995 • 69 citations

Direct binding of autoimmune disease related T cell epitopes to purified Lewis rat MHC class II molecules

1994 • 61 citations

Development of human Th1 and Th2 cytokine responses: The cytokine production profile of T cells is dictated by the primary in vitro stimulus

1993 • 50 citations

Modulation of the immune response with T-cell epitopes: the ultimate goal for specific immunotherapy of autoimmune disease.

1994 • 27 citations