Activation of mitogen-activated protein kinase by heat shock treatment in Drosophila

THE HEAT-SHOCK RESPONSE

1986 • 4,580 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 • 1,901 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

1995 • 1,562 citations

Phosphorylation of c-jun mediated by MAP kinases

1991 • 1,495 citations

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1992 • 1,146 citations

Nuclear localization and regulation of erk- and rsk-encoded protein kinases.

1992 • 1,107 citations

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

1990 • 1,087 citations

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1993 • 1,077 citations

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II

1988 • 1,032 citations

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

1992 • 948 citations

Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27

1994 • 866 citations

Heat shock factor and the heat shock response

1991 • 615 citations

Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins

1992 • 562 citations

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos

1993 • 555 citations

Extracellular signal-regulated kinases: ERKs in progress.

1991 • 519 citations

Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase

1991 • 491 citations

PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity

1992 • 480 citations

An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

1993 • 451 citations

Mitogen-activated protein kinases: versatile transducers for cell signaling

1992 • 439 citations

Stable binding of Drosophila heat shock factor to head-to-head and tail-to-tail repeats of a conserved 5 bp recognition unit

1989 • 439 citations

Involvement of p21ras in activation of extracellular signal-regulated kinase 2

1992 • 403 citations

Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies.

1991 • 392 citations

Stress-induced oligomerization and chromosomal relocalization of heat-shock factor

1991 • 391 citations

Purification and Properties of Drosophila Heat Shock Activator Protein

1987 • 388 citations

MAP kinase by any other name smells just as sweet

1992 • 341 citations

Nuclear Localization and Regulation of erk-and rsk-Encoded Protein Kinases

1992 • 246 citations

Heat shock and recovery are mediated by different translational mechanisms.

1982 • 211 citations

Stimulation of human neutrophils with formyl-methionyl-leucyl-phenylalanine induces tyrosine phosphorylation and activation of two distinct mitogen-activated protein-kinases.

1993 • 201 citations

Okadaic acid mimics the action of insulin in stimulating protein kinase activity in isolated adipocytes. The role of protein phosphatase 2a in attenuation of the signal.

1990 • 183 citations

Rapid changes in Drosophila transcription after an instantaneous heat shock.

1993 • 164 citations

Jun is phosphorylated by several protein kinases at the same sites that are modified in serum-stimulated fibroblasts.

1992 • 123 citations

Mitogen-activated protein kinase activation resulting from selective oncogene expression in NIH 3T3 and rat 1a cells.

1992 • 119 citations

Mitogen-activated Swiss mouse 3T3 RSK kinases I and II are related to pp44mpk from sea star oocytes and participate in the regulation of pp90rsk activity.

1991 • 118 citations

Primary structure, expression, and signal-dependent tyrosine phosphorylation of a Drosophila homolog of extracellular signal-regulated kinase.

1992 • 115 citations

Evaluation of isoelectric focusing running conditions during two-dimensional isoelectric focusing/sodium dodecyl sulfate-polyacrylamide gel electrophoresis: Variation of gel patterns with changing conditions and optimized isoelectric focusing conditions

1984 • 114 citations

Activation of myelin basic protein kinases during echinoderm oocyte maturation and egg fertilization

1988 • 110 citations

The Drosophila hsp70 message is rapidly degraded at normal temperatures and stabilized by heat shock

1988 • 109 citations

Evidence for communication between nerve growth factor and protein tyrosine phosphorylation

1990 • 107 citations

MAP kinase activation during heat shock in quiescent and exponentially growing mammalian cells

1993 • 73 citations

Heat stress stimulates inositol trisphosphate release and phosphorylation of phosphoinositides in CHO and Balb C 3T3 cells

1987 • 63 citations

Biochemical analysis of heat-resistant mouse tumor cell strains: a new member of the HSP70 family.

1989 • 50 citations

Rapid Changes in Drosophila Transcription After an Instantaneous Heat Shock

1993 • 47 citations

Selective Inhibition of Nerve Growth Factor‐Stimulated Protein Kinases by K‐252a and 5′‐S‐Methyladenosine in PC12 Cells

1989 • 45 citations

Jun Is Phosphorylated by Several Protein Kinases at the Same Sites That Are Modified in Serum-Stimulated Fibroblasts

1992 • 39 citations

Heat Shock Effects on Phosphorylation of Protein Synthesis Initiation Factor Proteins eIF-4E and eIF-2.alpha. in Drosophila

1995 • 37 citations

Cellular heat injury: are membranes involved?

1987 • 34 citations

Heat‐shock and related stress enhance RNA polymerase II C‐terminal‐domain kinase activity in HeLa cell extracts

1990 • 32 citations

Abnormal Forms of the Herpes Simplex Virus Immediate Early Polypeptide Vmw175 Induce the Cellular Stress Response

1987 • 29 citations

Transformation and tumor promoter sensitive phosphoproteins in JB-6 mouse epidermal cells: one is also sensitive to heat stress

1984 • 15 citations

Biochemical Analysis of Heat-Resistant Mouse Tumor Cell Strains: a New Member of the HSP70 Family

1989 • 11 citations

Response of Drosophila embryonic cells to tumor promoters

1986 • 8 citations

[IIa/IIo conversion of RNA polymerase II during heat shock].

1991 • 5 citations